6-chloro-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]-4-phenylquinolin-2(1H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-chloro-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]-4-phenylquinolin-2(1H)-one
• 英文别名: 6-chloro-3-(1-methyltetrazol-5-yl)sulfanyl-4-phenyl-1H-quinolin-2-one
• 化学式: C₁₇H₁₂ClN₅OS
• 分子量: 369.8
• InChiKey: MSYPFTPXDNQRKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  98
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• METHODS AND COMPOSITIONS FOR INHIBITION OF BROMODOMAIN-CONTAINING PROTEINS
  申请人：VANKAYALAPATI Hariprasad

  公开号：US20160024096A1

  公开（公告）日：2016-01-28

  The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.

  本发明涉及结合并调节含有溴域的蛋白质活性的化合物，以及制备这些化合物的方法，包括含有这些化合物的药物组合物和使用这些化合物治疗各种疾病和疾病的方法。
• Methods and compositions for inhibition of bromodomain-containing proteins
  申请人：ConverGene LLC

  公开号：US10266536B2

  公开（公告）日：2019-04-23

  The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.

  本发明涉及与含溴结构域蛋白质结合或以其他方式调节其活性的化合物、制备这些化合物的工艺、含有这些化合物的药物组合物，以及使用这些化合物治疗各种病症和疾病的方法。
• QUINOLINONE DERIVATIVES FOR THE INHIBITION OF BROMODOMAIN-CONTAINING PROTEINS
  申请人：ConverGene LLC

  公开号：EP2968360B1

  公开（公告）日：2021-01-20
• Methods and Compositions for Inhibition of Bromodomain-Containing Proteins
  申请人：ConverGene LLC

  公开号：US20180134715A1

  公开（公告）日：2018-05-17

  The present invention relates to compounds that bind to and otherwise modulate the activity of bromodomain-containing proteins, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders.
• US9695179B2
  申请人：——

  公开号：US9695179B2

  公开（公告）日：2017-07-04