1-((2,4-cis)-6-chloro-2-phenyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-((2,4-cis)-6-chloro-2-phenyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-one
• 英文别名: cis-6-chloro-4-(2-oxopyrrolidin-1-yl)-2-phenyl-1,2,3,4-tetrahydroquinoline；6-chloro-1,2,3,4-tetrahydro-4-(2-oxopyrrolidin-1-yl)-2-phenylquinoline；1-[(2S,4S)-6-chloro-2-phenyl-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one
• 化学式: C₁₉H₁₉ClN₂O
• 分子量: 326.826
• InChiKey: GYKHOXHVEWJTKP-ROUUACIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氯苯胺 在 [Cr(2,2'-bipyridine)3](CF₃SO₃)3 作用下， 以 乙腈 、 苯 为溶剂， 反应 3.0h， 生成 1-((2,4-cis)-6-chloro-2-phenyl-1,2,3,4-tetrahydroquinolin-4-yl)pyrrolidin-2-one
  参考文献：
  名称：

  光化学促进的Aza-Diels-Alder型反应：可见光辐照增强了Cr（III）/联吡啶配合物的高催化活性

  摘要：

  Cr（III）/联吡啶配合物在蓝光照射下可有效催化一系列N-芳基丙氨酸和官能化烯烃之间的Aza-Diels-Alder型环加成反应，得到相应的1,2,3,4-四氢喹啉高产率的非对映异构体衍生物。通常，亚苄基苯胺与1-乙烯基-2-吡咯烷酮的反应在底物与催化剂的摩尔比（S / C）为1000的情况下平稳进行，并在室温（20–25°C）下4小时内完成，从而获得环加成产物的产率为97％。

  DOI：

  10.1021/acs.joc.7b00838

文献信息

• Halogen Bond‐Catalyzed Povarov Reactions
  作者：Xuelei Liu、Patrick H. Toy

  DOI：10.1002/adsc.202000665

  日期：2020.8.19

  3‐dihydropyrrole. Very high isolated yields of the desired 1,2,3,4‐tetrahydroquinoline products were obtained with low catalyst loadings (0.01 equivalents) and short reaction times (minutes to hours) at ambient temperature. Notably, the bis(benzimidazolium iodide)‐based catalyst used in these reactions proved to be more efficient than analogous bromine and chlorine functionalized compounds, as well as a related

  据报道，使用双齿卤素键供体来催化衍生自芳基醛和苯胺的亚胺的Povarov反应。在这些反应中使用的亲双烯体包括2,3-二氢呋喃，N-乙烯基-2-吡咯烷酮和NCbz保护的2，3-二氢吡咯。在环境温度下，以较低的催化剂负载量（0.01当量）和较短的反应时间（数分钟至数小时）获得了所需1,2,3,4-四氢喹啉产物的很高的分离产率。值得注意的是，在这些反应中使用的基于双（碘化咪唑鎓）的催化剂被证明比类似的溴和氯官能化化合物以及相关的单齿碘化亚苄基碘更有效。这些观察结果与其他人关于卤素键有机催化的报道相似，随着该领域的发展，可能对指导催化剂设计很有用。
• Nitrosonium (NO+) initiated and cation radical-mediated imino Diels–Alder reaction
  作者：Yulu Zhou、Xiaodong Jia、Rui Li、Zhengang Liu、Zhongli Liu、Longmin Wu

  DOI：10.1016/j.tetlet.2005.10.083

  日期：2005.12

  An efficient aza-Diels–Alder reaction of N-arylimines with N-vinylpyrrolidinone was achieved using nitrosonium tetrafluoroborate as a cation radical initiator, giving cis-4-(2-oxopyrrolidin-1-yl)tetrahydroquinolines in various yields.

  使用四氟硼酸亚硝鎓作为阳离子自由基引发剂，可以实现N-芳基丙氨酸与N-乙烯基吡咯烷酮的有效aza-Diels-Alder反应，得到不同产率的顺式-4-（2-氧吡咯烷基-1-基）四氢喹啉。
• Mild and Simple Access to Diverse 4-Amino-substituted 2-Phenyl-1,2,3,4-tetrahydroquinolines and 2-Phenylquinolines Based on a Multicomponent Imino Diels–Alder Reaction
  作者：P. Prabhakara Varma、Bailure S. Sherigara、Kittappa M. Mahadevan、Vijaykumar Hulikal

  DOI：10.1080/00397910903221035

  日期：2010.7.12

  A straightforward synthesis of new 1-(2-phenyl-1,2,3,4-tetrahydroquinolin-4-yl) pyrrolidin-2-ones/azepan-2-one from N-vinyl caprolactam/N-vinylpyrrolidin-2-one and N-benzylideneaniline via the imino Diels-Alder reaction has been reported for the first time. Antimony(III) chloride has been shown to effectively catalyze imino-Diels-Alder reaction to afford both 2-phenylquinoline and 2-phenyl-1,2,3,4-tetrahydroquinolin derivatives in excellent yields at ambient temperature. The cis diastereoselectivity to give cis 2-phenyl-1,2,3,4-tetrahydroquinolines is also highlighted in this reaction.
• Imino Diels-Alder Reactions: Efficient Synthesis of 2-Aryl-4-(2′-oxopyrrolidinyl-1′)-1,2,3,4-tetrahydroquinolines catalyzed by Antimony(III) Sulfate
  作者：Aswathanarayana Srinivasa、Kittappa M. Mahadevan、Vijaykumar Hulikal

  DOI：10.1007/s00706-007-0777-0

  日期：2008.3

  Antimony(III) sulfate is found to catalyze the imino Diels-Alder reaction of Schiff's bases with N-vinylpyrrolidin-2-one to afford 2-aryl-4-(2'-oxopyrrolidinyl-1')-1,2,3,4-tetrahydroquinolines. One-pot synthesis of 1,2,3,4-tetrahydroquinolines from 3-nitro benzaldehyde and aromatic amines with N-vinylpyrrolidin-2-one catalyzed by antimony(III) sulfate is also reported. This catalyst is inexpensive, easily available, and it was also found that catalyst could be recovered quantitatively and reused without much loss of catalytic activity.
• Photochemically catalyzed Diels–Alder reaction of arylimines with N-vinylpyrrolidinone and N-vinylcarbazole by 2,4,6-triphenylpyrylium salt: synthesis of 4-heterocycle-substituted tetrahydroquinoline derivatives
  作者：Wei Zhang、Yanping Guo、Zhengang Liu、Xiaoling Jin、Li Yang、Zhong-Li Liu

  DOI：10.1016/j.tet.2004.11.042

  日期：2005.1

  Photochemically promoted Diels-Alder reactions of N-arylimines with N-vinylpyrrolidinone and N-vinylcarbazole were achieved by using 2,4,6-triphenylpyrylium tetrafluoroborate as a catalyst to produce corresponding 2-oxopyrrolidin-1-yl and carbazol-9-yltetrahydroquinolines in high yields. (C) 2004 Elsevier Ltd. All rights reserved.