ractopamine 10'-glucuronide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ractopamine 10'-glucuronide
• 英文别名: Ractopamine-10'-O-beta-glucuronide (Mixture of Diastereomers)；(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[4-[1-hydroxy-2-[4-(4-hydroxyphenyl)butan-2-ylamino]ethyl]phenoxy]oxane-2-carboxylic acid
• 化学式: C₂₄H₃₁NO₉
• 分子量: 477.511
• InChiKey: OGONAMDDSCABIY-AZJJIUSTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  169
• 氢给体数：
  7
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  盐酸莱克多巴胺 、 6-[[[5-(2,4-二氧代嘧啶-1-基)-3,4-二羟基四氢呋喃-2-基]甲氧基-羟基磷酰]氧基-羟基磷酰]氧基-3,4,5-三羟基四氢吡喃-2-羧酸 在 rabbit liver microsomes 作用下， 以 phosphate buffer 为溶剂， 生成 ractopamine 10'-glucuronide 、 ractopamine 10-glucuronide
  参考文献：
  名称：

  Identification of turkey biliary metabolites of ractopamine hydrochloride and the metabolism and distribution of synthetic [¹⁴C]ractopamine glucuronides in the turkey

  摘要：

  1. The bile duct cannulated turkey poult (n = 3) dosed orally with [C-14]ractopamine HCl {(1R*, 3R*),(1R*,3S*)-4-hydroxy-alpha-[[[3-(4-hydroxy[C-14]phenyl)-1-methylpropyl]- amino]methyl]-benzenemethanol hydrochloride; 19.9 mg; 9.28 mu Ci} excreted 37.4 +/- 12.1% (mean+/-SD) of the administered radioactivity in bile by 24 h post-dosing.2. A mono-glucuronide, conjugated at C-10 (the methylpropylamino phenol) of ractopamine, accounted for 76.6 % of biliary radioactivity.3. Urine collected from the colostomized turkey poult (n = 3) orally dosed with synthetic [C-14]ractopamine-glucuronides (10.1 mg; 3.6 mu Ci) contained 11.9+/-1.0% (mean+/-SD) of the administered radioactivity 24 h after dosing. indicating that some absorption of radioactivity occurred. Faeces contained 60.6% of the administered radioactivity and carcasses (with gastrointestinal tracts) contained 23.3 %, of the starting radioactivity.4. Five colostomized poults were fitted with bile duct cannulas and were dosed intraduodenally with 10.2 mg (3.6 mu Ci) synthetic [C-14]ractopamine-glucuronides. Urine and bile contained 15.5 +/- 2.2 and 16.8 +/- 2.1 % respectively of the administered radiocarbon by 24 h post-dosing. Faeces contained 54.3% of the administered radioactivity. Total absorption of the dosed radioactivity aleraged 33.4 %.5. Bile and urine collected from the colostomized, bile-duct cannulated bird contained mainly ractopamine glucuronides. Indirect evidence suggests that the dosed ractopamine glucuronides were nor absorbed intact.

  DOI：

  10.1080/004982500237613