octadecanoic acid-2-hydroxy-2-methyl-propyl-amide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: octadecanoic acid-2-hydroxy-2-methyl-propyl-amide
• 英文别名: N-(2-hydroxy-2-methylpropyl)octadecanamide
• 化学式: C₂₂H₄₅NO₂
• 分子量: 355.605
• InChiKey: WOSZPOWEDXMMOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  25
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  对氯苯异氰酸酯 、 octadecanoic acid-2-hydroxy-2-methyl-propyl-amide 在 dibutyltin(II) dilaurate 作用下， 反应 14.0h， 以88%的产率得到1,1-dimethyl-2-(octadecanoyl-amino)-ethyl-N-4-chlorophenyl-carbamate
  参考文献：
  名称：

  Modified tert-butyloxycarbonyl(BOC) derivatives as new aminoprotecting groups

  摘要：

  Some novel low-molecular weight and polymerizable N-acylamino-modified BOC-type aminoprotecting groups are described. Deprotection with trifluoroacetic acid (TFA) and with HBr in acetic acid, which was followed by NMR spectroscopy, leads to the formation of 4,S-dihydro-oxazole derivatives. Reactivities and solubilities of the new compounds are controlled significantly by the N-acyl moiety.

  DOI：

  10.1016/s0040-4020(01)87972-2
• 作为产物：
  描述：

  1-氨基-2-甲基-2-丙醇 、 硬脂酸 在 氯甲酸乙酯 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以72%的产率得到octadecanoic acid-2-hydroxy-2-methyl-propyl-amide
  参考文献：
  名称：

  Modified tert-butyloxycarbonyl(BOC) derivatives as new aminoprotecting groups

  摘要：

  Some novel low-molecular weight and polymerizable N-acylamino-modified BOC-type aminoprotecting groups are described. Deprotection with trifluoroacetic acid (TFA) and with HBr in acetic acid, which was followed by NMR spectroscopy, leads to the formation of 4,S-dihydro-oxazole derivatives. Reactivities and solubilities of the new compounds are controlled significantly by the N-acyl moiety.

  DOI：

  10.1016/s0040-4020(01)87972-2