1-menthol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-menthol
• 英文别名: 3-Methyl-3-propan-2-ylcyclohexan-1-ol
• 化学式: C₁₀H₂₀O
• 分子量: 156.268
• InChiKey: GXVKKGSUMOYXRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-menthol 生成 哌非尼酮
  参考文献：
  名称：

  ADHESIVE MATERIAL CONTAINING 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE

  摘要：

  公开号：

  EP2359827B1
• 作为产物：
  描述：

  1-phenylalanine-1-menthylester 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 生成 1-menthol
  参考文献：
  名称：

  Resolution of racemic amino acids

  摘要：

  外消旋氨基酸可以通过转化为具有光学活性的2-异丙基-5-甲基环己醇的对映异构酯并通过色谱法分离对映异构体来轻松分离。观察到，对映异构酯的分离对支持体或溶剂的选择相对不敏感。因此，在广泛的条件下都能实现令人满意的分离。利用纯化的对映异构体进行碱催化水解，可以获得具有高光学纯度的光学活性氨基酸。

  公开号：

  US04379941A1
• 作为试剂：
  描述：

  1,4-dihydro-6-methyl-4-(3-nitrophenyl)-pyridazine-3,5-dicarboxylic acid 5-ethyl ester 、 硫酸 以 1-menthol 为溶剂， 以42%的产率得到1,4-Dihydro-6-methyl-4-(3-nitrophenyl)-pyridazine-3,5-dicarboxylic acid 5-ethyl 3-1-menthyl ester
  参考文献：
  名称：

  1,4-Dihydropyridazine-3-carboxylic acid derivatives, a process for their

  摘要：

  本发明涉及1,4-二氢吡嗪-3-羧酸衍生物及含有该衍生物的组合物。本发明还包括制造和使用该化合物和组合物的方法。本发明的衍生物影响循环，并具有解痉和抗炎作用。

  公开号：

  US04280998A1

文献信息

• Process for the preparation of 2-substituted and 2,3-disubstituted
  申请人：Hoffmann-La Roche Inc.

  公开号：US05399712A1

  公开（公告）日：1995-03-21

  The invention relates to a process for the manufacture of substituted maleimides of the formula ##STR1## wherein R.sup.1 is alkyl, aryl or heteroaryl and R.sup.2 is hydrogen, alkyl, alkoxycarbonyl, aryl or heteroaryl, by reacting an activated glyoxylate of the formula ##STR2## wherein R.sup.1 has the above significance and X is a leaving atom or group, with an imidate of the formula ##STR3## wherein R.sup.2 has the above significance, R.sup.3 is alkyl, aryl or trialkylsilyl and Y is oxygen or sulfur, in the presence of a base and, after treating the resulting reaction product obtained in which R.sup.2 is hydrogen or alkyl with a strong base, hydrolyzing and dehydrating the resulting hydroxy-pyrrolinone of the formula ##STR4## wherein R.sup.1, R.sup.2, R.sup.3 and Y have the above significance. The substituted maleimides of formula I are pharmacologically active, for example as protein kinase C inhibitors and which a useful, for example, in the treatment and prophylaxis of inflammatory, immunological, bronchopulmonary and cardiovascular disorders, or as antiproliferative agents useful, for example, in the treatment of immune diseases and allergic disorders.

  该发明涉及一种制备式为##STR1##的取代马来酰亚胺的方法，其中R.sup.1是烷基、芳基或杂环芳基，R.sup.2是氢、烷基、烷氧羰基、芳基或杂环芳基，通过将式为##STR2##的活化的甘醇酸酯与式为##STR3##的亚胺在碱存在下反应，其中R.sup.1具有上述含义，X是一个脱离原子或基团，然后处理所得的反应产物，其中R.sup.2是氢或烷基，用强碱处理后，水解和脱水所得的式为##STR4##的羟基吡咯烷酮，其中R.sup.1、R.sup.2、R.sup.3和Y具有上述含义。式I的取代马来酰亚胺在药理学上具有活性，例如作为蛋白激酶C抑制剂，可用于治疗和预防炎症、免疫、支气管肺部和心血管疾病，或作为抗增殖剂，例如用于治疗免疫性疾病和过敏性疾病。
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES
  申请人：GIVAUDAN SA

  公开号：WO2021102896A1

  公开（公告）日：2021-06-03

  Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa.

  公开了根据式(I)定义的TRPM8调节剂，用于在皮肤和粘膜上实现降温效果。
• Thia-aza compounds with a .beta.-lactam ring
  申请人：Ciba-Geigy Corporation

  公开号：US04331676A1

  公开（公告）日：1982-05-25

  2-Penem-3-carboxylic acid compounds of the formula ##STR1## in which R.sub.1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom or an etherified mercapto group and R.sub.2 represents hydroxy or a radical R.sub.2.sup.A forming together with the carbonyl grouping --C(.dbd.O)-- a protected carboxyl group, 1-oxides thereof, as well as salts of such compounds having salt-forming groups, in racemic and optically active form, processes for their preparation, pharmaceutical compositions containing such compounds, and their use as antibiotics, and intermediates and their processes which are useful in the production of the compounds of the formula I.

  公式为##STR1##的2-青霉素-3-羧酸化合物，其中R.sub.1代表氢，由碳原子与环碳原子结合的有机基团或醚化巯基团，R.sub.2代表羟基或与羰基团--C(.dbd.O)--一起形成保护羧基的基团R.sub.2.sup.A，其1-氧化物，以及具有形成盐的盐基团的这种化合物的盐，以拉克米和光学活性形式存在，它们的制备方法，含有这种化合物的药物组合物，以及它们作为抗生素的用途，以及在生产公式I化合物中有用的中间体及其制备方法。
• 5,6,7,-Trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives and
  申请人：Toray Industries, Inc.

  公开号：US04564620A1

  公开（公告）日：1986-01-14

  Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-13,14-didehydro PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-16,16-dimethyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-17-.alpha.-methyl-20-homo PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-phenoxy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-20-isopropylidene PGI.sub.2, 5,6,7-trinor-4,8-inter-(5-methyl-1,3-phenylene) PGI.sub.2, and 5,6,7-trinor-4,8-inter-m-phenylene-2,3-didehydro-16,17,18,19,20-pentanor-1 5-phenyl PGI.sub.2. They are useful in treatment of ulcers, thrombii and hypertension for example.

  药用化合物是5,6,7-三缺一-4,8-相间-间苯二酚 PGI.sub.2 衍生物，例如 5,6,7-三缺一-4,8-相间-间苯二酚-13,14-二去氢 PGI.sub.2，5,6,7-三缺一-4,8-相间-间苯二酚-16,16-二甲基 PGI.sub.2，5,6,7-三缺一-4,8-相间-间苯二酚-17-.alpha.-甲基-20-同源 PGI.sub.2，5,6,7-三缺一-4,8-相间-间苯二酚-17,18,19,20-四缺一-16-苯氧基 PGI.sub.2，5,6,7-三缺一-4,8-相间-间苯二酚-20-异丙亚甲基 PGI.sub.2，5,6,7-三缺一-4,8-相间-(5-甲基-1,3-苯基) PGI.sub.2，和 5,6,7-三缺一-4,8-相间-间苯二酚-2,3-二去氢-16,17,18,19,20-五缺一 5-苯基 PGI.sub.2。它们在治疗溃疡、血栓和高血压等方面具有用途。
• 5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI.sub.2 derivatives and
  申请人：Toray Industries, Inc.

  公开号：US04822804A1

  公开（公告）日：1989-04-18

  Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(S)-methyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(R)-methyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl-.omega.-homo PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(S)-methyl-.omega.-homo PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(R)-methyl-.omega.-homo PGI.sub.2, 5,6, 7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16,16-dimethyl-16-p ropoxy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2,18,19,20-tetranor-16,16-dimethyl-17-et ho xy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2,18,19,20-tetranor-16,16-dimethyl-17-pr op oxy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16-phenoxy PGI.sub.2 and methyl esters thereof. 5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16,16-dimethyl-16 -phenoxy PGI.sub.2 or its methyl ester, 5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16-methyl-16-phe nox y PGI.sub.2 or its methyl ester. They are useful in treatment of ulcers, thrombii and hypertension for example.

  药用化合物是5,6,7-三去氢-4,8-间-m-苯撑PGI.sub.2衍生物，如5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-16,16-二甲基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-17(S)-甲基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-17(R)-甲基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-16,16-二甲基-ω-同系PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-17(S)-甲基-ω-同系PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-17(R)-甲基-ω-同系PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2,17,18,19,20-五去氢-16,16-二甲基-16-丙氧基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2,18,19,20-四去氢-16,16-二甲基-17-乙氧基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2,18,19,20-四去氢-16,16-二甲基-17-丙氧基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2,17,18,19,20-五去氢-16-苯氧基PGI.sub.2及其甲酯。5,6,7-三去氢-4,8-间-m-苯撑-2,17,18,19,20-五去氢-16,16-二甲基-16-苯氧基PGI.sub.2或其甲酯，5,6,7-三去氢-4,8-间-m-苯撑-2,17,18,19,20-五去氢-16-甲基-16-苯氧基PGI.sub.2或其甲酯。它们可用于治疗溃疡、血栓和高血压等疾病。