1-(1,3-diphenylprop-2-ynyl)piperazine

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(1,3-diphenylprop-2-ynyl)piperazine
• 英文别名: 1-(1,3-Diphenylprop-2-ynyl)piperazine
• 化学式: C₁₉H₂₀N₂
• 分子量: 276.381
• InChiKey: RTHZVAKURCENML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  哌嗪 、 苯甲醛 、 苯乙炔 在 CuPy₂Cl₂ 作用下， 反应 0.03h， 以92%的产率得到1-(1,3-diphenylprop-2-ynyl)piperazine
  参考文献：
  名称：

  CuPy2Cl2：一种在常规方法和微波辐射下合成炔丙胺的新型高效催化剂

  摘要：

  摘要 CuPy2Cl2 是一种有效的催化剂，通过芳香醛、胺和芳香炔烃在 95 °C 下搅拌，通过三组分偶联反应制备炔丙胺，并且不使用任何溶剂，以良好的收率得到相应的产物。将反应混合物在微波炉中以 450 W 辐照，以优异的产率提供预期的产物。

  DOI：

  10.1080/00397910802109307

文献信息

• Mannich reactions of resin-bound substrates: 2. A versatile three-component solid-phase organic synthesis methodology
  作者：James J. McNally、Mark A. Youngman、Scott L. Dax

  DOI：10.1016/s0040-4039(97)10716-x

  日期：1998.2

  Alkynes, secondary amines and aldehydes, in the presence of a copper (I) salt, undergo Mannich reactions to afford the corresponding aminomethylalkynyl adducts on a solid support. Any member of this three-component reaction system can be immobilized on a resin providing three distinct routes for the generation of structurally diverse compound libraries.

  在铜（I）盐的存在下，炔烃，仲胺和醛经历曼尼希反应，以在固体载体上提供相应的氨基甲基炔基加合物。该三组分反应系统的任何成员都可以固定在树脂上，从而提供了三种不同的途径来生成结构多样的化合物库。
• Ag-Based Coordination Polymers Based on Metalloligands and Their Catalytic Performance in Multicomponent A³-Coupling Reactions
  作者：Gulshan Kumar、Saurabh Pandey、Rajeev Gupta

  DOI：10.1021/acs.cgd.8b00833

  日期：2018.9.5

  Two silver(I)-based coordination polymers (CPs), namely, 1-Ag and 2-Ag, have been synthesized by the reaction of Co-based metalloligands offering appended pyridyl groups. X-ray diffraction analyses revealed three-dimensional (3D) architectures for both 1-Ag and 2-Ag due to the coordination of Ag(I) ions to that of appended pyridyl groups. In the case of 1-Ag, transition from a two-dimensional network

  通过提供附加的吡啶基的Co基金属配体的反应，合成了两种基于银（I）的配位聚合物（CP），即1-Ag和2-Ag。X射线衍射分析揭示了1-Ag和2-Ag的三维（3D）结构，这归因于Ag（I）离子与附加吡啶基的配位。在1-Ag的情况下，由于存在亲银性相互作用，因此显示了从二维网络到最终3D网络的过渡。这两个CP均显示出值得注意的结构差异和有趣的拓扑结构，这是由于Ag（I）离子与金属配体的配位作用。两个CP均充当A 3的非均相催化剂-醛，仲胺和炔的偶联反应。可回收性实验证实了CPs在异质促进A 3偶联反应中的稳定性质。
• Highly Efficient Cadmium-Catalyzed Three-Component Coupling of an Aldehyde, Alkyne, and Amine via C-H Activation under Microwave Conditions
  作者：Krishna Singh、Dushyant Raghuvanshi

  DOI：10.1055/s-0030-1259323

  日期：2011.2

  The first use of Cd 2 + as catalystfor a facile three-component coupling of an aldehyde, alkyne, andamine has been demonstrated to synthesize propargylamines undermicrowave irradiation in chlorobenzene without the use of a co-catalystor activator in the absence of inert atmosphere. This method hasbeen proved to be applicable to a wide range of substrates.

  首次使用 Cd 2 + 作为催化剂对醛、炔和胺进行三组分偶联，已被证明可以在氯苯中在微波辐射下合成炔丙胺，而无需使用助催化剂活化剂，在没有惰性气氛的情况下。该方法已被证明适用于广泛的基材。
• Nano Ag-doped magnetic-Fe3O4@mesoporous TiO2 core–shell hollow spheres: synthesis and enhanced catalytic activity in A3 and KA2 coupling reactions
  作者：Ali Elhampour、Friuozeh Nemati、Majid M. Heravi

  DOI：10.1007/s00706-017-1948-2

  日期：2017.10

  Nano Ag-doped Fe3O4@mesoporous TiO2 core-shell hollow spheres (h-Fe3O4@m-TiO2/Ag) were efficiently prepared. They were fully characterized by FT-IR, FE-SEM, EDX, ICP, TGA, XRD, and BET methods. In addition, their magnetic properties were determined by means of the VSM method. Also, the rho (shell) of the prepared hollow Fe3O4 micro-particles was calculated, being found just slightly lighter than that of solid sphere-like Fe3O4. The catalytic activity of this novel catalyst system was successfully examined as a novel catalyst system in A(3) coupling reactions (aldehyde + amine + acetylene). This highly active magnetic catalyst was easily separated using an external magnet and re-used in five consecutive runs in the model reaction without appreciable loss of its catalytic activity.[GRAPHICS].
• Zn(OAc)2·2H2O: a versatile catalyst for the one-pot synthesis of propargylamines
  作者：Enugala Ramu、Ravi Varala、Nuvula Sreelatha、Srinivas R. Adapa

  DOI：10.1016/j.tetlet.2007.07.196

  日期：2007.10

  An inexpensive and readily available catalyst, Zn(OAc)(2)center dot 2H(2)O is successfully evaluated for effective one-pot synthesis of propargylamines with moderate to excellent yields for most of the substrates screened, without the need of base, co-catalyst or additive in the presence of air. (C) 2007 Elsevier Ltd. All rights reserved.