3-amino-N-(prop-2-ynyl)propanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-amino-N-(prop-2-ynyl)propanamide
• 英文别名: 3-amino-N-(prop-2-yn-1-yl)propanamide；3-amino-N-prop-2-ynylpropanamide
• 化学式: C₆H₁₀N₂O
• mdl: MFCD09934198
• 分子量: 126.158
• InChiKey: OZBJBNQHMAXGTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-amino-N-(prop-2-ynyl)propanamide 、 万古霉素 在 N-羟基-7-氮杂苯并三氮唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N-甲基吗啉 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.08h， 生成
  参考文献：
  名称：

  Evaluation of the antibacterial and antibiofilm activities of novel CRAMP–vancomycin conjugates with diverse linkers

  摘要：

  CRAMP（与抗菌肽相关的防御素）和万古霉素的共轭物通过使用多样的亲水性和疏水性连接剂进行点击化学合成。

  DOI：

  10.1039/c5ob00830a
• 作为产物：
  描述：

  tert-butyl 3-oxo-3-(prop-2-ynylamino)propylcarbamate 在 盐酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 以88%的产率得到3-amino-N-(prop-2-ynyl)propanamide
  参考文献：
  名称：

  Evaluation of the antibacterial and antibiofilm activities of novel CRAMP–vancomycin conjugates with diverse linkers

  摘要：

  CRAMP（与抗菌肽相关的防御素）和万古霉素的共轭物通过使用多样的亲水性和疏水性连接剂进行点击化学合成。

  DOI：

  10.1039/c5ob00830a

文献信息

• Templated molecules and methods for using such molecules
  申请人：Nuevolution A/S

  公开号：EP2305808B1

  公开（公告）日：2016-03-02
• IMIDAZO[1,2-A]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
  申请人：Lee C. Ken

  公开号：US20080085896A1

  公开（公告）日：2008-04-10

  The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
• IMIDAZO[1,2-a]PYRIDINE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
  申请人：Lee Ken C.

  公开号：US20100105721A1

  公开（公告）日：2010-04-29

  The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).
• MASS LABELS
  申请人：ELECTROPHORETICS LIMITED

  公开号：US20170045526A1

  公开（公告）日：2017-02-16

  The present invention provides a method for labelling one or more analytes in a sample, the method comprising: a) contacting the sample with one or more bifunctional linker reagents having the general formula Re 1 -L 1 -Re 2 , wherein Re 1 is a first reactive group, L 1 is a linker moiety and Re 2 is a second reactive group, wherein Re 1 reacts with an analyte to form a modified analyte; and b) contacting the sample with one or more mass labels, wherein Re 2 of the bifunctional linker attached to the analyte reacts with a mass label to form a labelled analyte, wherein each mass label is relatable to an analyte by mass spectrometry.
• US7666880B2
  申请人：——

  公开号：US7666880B2

  公开（公告）日：2010-02-23