9-amino-2-thia-2,3-dihydro-1H-cyclopenta[b]quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-amino-2-thia-2,3-dihydro-1H-cyclopenta[b]quinoline
• 英文别名: 9-amino-1,3-dihydrothieno[3,4-b]quinoline；1,3-dihydrothieno[3,4-b]quinolin-9-amine
• 化学式: C₁₁H₁₀N₂S
• 分子量: 202.28
• InChiKey: TWEHSFFLURLJJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  64.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基苯甲腈 生成 9-amino-2-thia-2,3-dihydro-1H-cyclopenta[b]quinoline
  参考文献：
  名称：

  SHUTSKE, GREGORY M.;EFFLAND, RICHARD C.

  摘要：

  DOI：

文献信息

• Quinoline derivatives
  申请人：SUMITOMO PHARMACEUTICALS COMPANY, LIMITED

  公开号：EP0268871A1

  公开（公告）日：1988-06-01

  Quinoline derivatives of the formula, wherein R1, R2, R3 and R4 are each hydrogen or one of a specific range of substituents, is one of a specific range of cyclic groups, and are useful as pharmaceuticals such as anti-senile dementia. They may be prepared by synthetic routes analogous to those described in the literature for preparing known compounds.

  喹啉衍生物的公式，其中R1、R2、R3和R4各自是氢或特定范围内的一个取代基，是一个特定范围内的环状基团，并且可用作抗老年痴呆症等药物。它们可以通过与文献中描述的已知化合物相似的合成路线来制备。
• Fused heteroalkylene quinolinamines
  申请人：Hoechst-Roussel Pharmaceuticals, Inc.

  公开号：US04843079A1

  公开（公告）日：1989-06-27

  There are disclosed compounds having the formula ##STR1## wherein n is 1-4; R is hydrogen, loweralkyl or loweralkylcarbonyl; R.sub.1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, oxygen-bridge arylloweralkyl, or oxygen-bridged diaryllowerallyl; A is a direct bond or (CHR.sub.3).sub.m, m being 1-3; X is hydrogen, loweralkyl, cycloalkyl,, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, --SH, loweralkylthio, --NHCOR.sub.4 or --NR.sub.5 R.sub.6, R.sub.4 being hydrogen or loweralkyl, and R.sub.6 and R.sub.6 being independently hydrogen, loweralkyl or cycloalkyl; Y is O, S or NR.sub.7 ; and each R.sub.2, each R.sub.3 and R.sub.7 are independently hydrogen or loweralkyl, or taken two at a time form a methylene or ethylene group constituting a part of a ring of at least five atoms; stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.

  披露了具有以下结构的化合物：其中n为1-4；R为氢、较低烷基或较低烷基羰基；R.sub.1为氢、较低烷基、较低烷基羰基、芳基、二较低烷基氨基较低烷基、芳基较低烷基、二芳基较低烷基、氧桥芳基较低烷基或氧桥二芳基烯基；A为直链键或(CHR.sub.3).sub.m，其中m为1-3；X为氢、较低烷基、环烷烃、较低烷氧基、卤素、羟基、硝基、三氟甲基、甲酰基、较低烷基羰基、芳基羰基、-SH、较低烷硫基、-NHCOR.sub.4或-NR.sub.5 R.sub.6，其中R.sub.4为氢或较低烷基，R.sub.6和R.sub.6分别为氢、较低烷基或环烷烃；Y为O、S或NR.sub.7；每个R.sub.2、每个R.sub.3和R.sub.7独立地为氢或较低烷基，或者两者组成至少五个原子的环的一部分的亚甲基或乙烯基；其立体、光学和几何异构体，以及其药学上可接受的酸盐，可用于增强记忆。
• Fused heteroalkylene quinolinamines and use as cholinergic agents
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05002955A1

  公开（公告）日：1991-03-26

  There are disclosed compounds having the formula ##STR1## wherein n is 1-4; R is hydrogen, loweralkyl or loweralkylcarbonyl; R.sub.1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl, or oxygen-bridged diaryllowerallyl; A is a direct bond or (CHR.sub.3).sub.m, m being 1-3; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, --SH, loweralkylthio, --NHCOR.sub.4 or --NR.sub.5 R.sub.6, R.sub.4 being hydrogen or loweralkyl, and R.sub.5 and R.sub.6 being independently hydrogen, loweralkyl or cycloalkyl; Y is O, S or NR.sub.7 ; and each R.sub.2, each R.sub.3 and R.sub.7 are independently hydrogen or loweralkyl, or taken two at a time form a methylene or ethylene group constituting a part of a ring of at least five atoms; stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.

  公开了具有下式的化合物：##STR1## 其中n为1-4；R为氢、低碳基或低碳基羰基；R.sub.1为氢、低碳基、低碳基羰基、芳基、二低碳基氨基低碳基、芳基低碳基、二芳基低碳基、氧桥联的芳基低碳基或氧桥联的二芳基低烯烃基；A为直接键或（CHR.sub.3）.sub.m，其中m为1-3；X为氢、低碳基、环烷基、低碳氧基、卤素、羟基、硝基、三氟甲基、甲酰基、低碳基羰基、芳基羰基、--SH、低碳基硫基、--NHCOR.sub.4或--NR.sub.5R.sub.6，其中R.sub.4为氢或低碳基，R.sub.5和R.sub.6独立地为氢、低碳基或环烷基；Y为O、S或NR.sub.7；每个R.sub.2、每个R.sub.3和R.sub.7独立地为氢或低碳基，或者两个一起形成至少五个原子的环的一部分的亚甲基或乙烯基；其立体、光学和几何异构体以及药学上可接受的酸加合物，这些化合物对增强记忆有用。
• Fused heteroalkylene quinolinamines, a process and intermediates for their preparation and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0287977A2

  公开（公告）日：1988-10-26

  There are disclosed compounds having the formula wherein n is 1-4; R is hydrogen, loweralkyl or loweralkylcarbonyl; R₁ is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl, or oxygen-bridged diaryllowerallyl; A is a direct bond or (CHR₃)m, m being 1-3; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, -SH, loweralkylthio, -NHCOR₄ or -NR₅R₆, R₄ being hydrogen or loweralkyl, and R₅ and R₆ being independently hydrogen, loweralkyl or cycloalkyl; Y is O, S or NR₇; and each R₂, each R₃ and R₇ are independently hydrogen or loweralkyl, or taken two at a time form a methylene or ethylene group constituting a part of a ring of at least five atoms; stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.

  所公开的化合物具有以下式子 其中 n 为 1-4；R 为氢、低级烷基或低级烷基羰基；R₁ 为氢、低级烷基、低级烷基羰基、芳基、稀烷基氨基低级烷基、芳基低级烷基、二芳基低级烷基、氧桥接芳基低级烷基或氧桥接二芳基低级烯丙基；A 为直接键或 (CHR₃)m，m 为 1-3；X是氢、低级烷基、环烷基、低级烷氧基、卤素、羟基、硝基、三氟甲基、甲酰基、低级烷基羰基、芳基羰基、-SH、低级烷硫基、-NHCOR₄或-NR₅R₆，其中R₄是氢或低级烷基，R₅和R₆独立地是氢、低级烷基或环烷基；Y为O、S或NR₇；且每个R₂、每个R₃和R₇独立为氢或低级烷基，或一次取两个形成亚甲基或亚乙基，构成至少五个原子的环的一部分；其立体异构体、光学异构体和几何异构体及其药学上可接受的酸加成盐，可用于增强记忆力。
• SHUTSKE, GREGORY M.;EFFLAND, RICHARD C.
  作者：SHUTSKE, GREGORY M.、EFFLAND, RICHARD C.

  DOI：——

  日期：——