二[(1-氧代-2-丙烯基)氨基]-乙酸 | 4387-85-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 二[(1-氧代-2-丙烯基)氨基]-乙酸
• 英文名称: 2,2-bis-(acrylamido)acetic acid
• 英文别名: N,N'-bis(acrylamido)acetic acid；2,2-bis(acrylamido)acetic acid；bis[(1-oxoallyl)amino]acetic acid；2,2-bis-acrylamidoacetic acid；bis(acrylamido)acetic acid；diacrylamido acetic acid；Acetic acid, bis[(1-oxo-2-propenyl)amino]-；2,2-bis(prop-2-enoylamino)acetic acid
• CAS: 4387-85-3
• 化学式: C₈H₁₀N₂O₄
• 分子量: 198.178
• InChiKey: LVKKFNORSNCNPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

安全信息

• 危险等级：
  8
• 海关编码：
  2924199090
• 包装等级：
  III
• 危险类别：
  8
• 危险品运输编号：
  UN 3261

反应信息

• 作为反应物：
  描述：

  二[(1-氧代-2-丙烯基)氨基]-乙酸 在 氯化亚砜 、 N,N-二异丙基乙胺 作用下， 以 甲醇 为溶剂， 反应 10.0h， 生成 bis[N,N'-(2-(2-aminoethyl)thioethylamido)]acetate
  参考文献：
  名称：

  Synthesis of N,N‘-bis(Acrylamido)acetic Acid-Based T-Antigen Glycodendrimers and Their Mouse Monoclonal IgG Antibody Binding Properties

  摘要：

  Novel glycodendrimers based on N,N'-bis(acrylamido)acetic acid core with valencies between two and six were synthesized. The breast cancer-associated T-antigen carbohydrate marker, (beta -Gal-(1 -3)-alpha -GalNAc-OR), was then conjugated by (i) 1,4-conjugate addition of thiolated T-antigen to the N-acrylamido dendritic cores and by (ii) amide bond formation between an acid derivative of the T-antigen and the polyamino dendrimers. The protein-binding ability of these new glycodendrimers was fully demonstrated by turbidimetric analysis and by enzyme-linked immunosorbent assay (ELISA) using peanut lectin from Arachis hypogaea and a mouse monoclonal antibody (MAb) FAA-J11 (IgG3). When tested as inhibitors of binding between: MAb and a polymeric form of the T-antigen (T-antigen-co-polyacrylamide) used as a coating antigen, di(17), tetra- (20), hexa- (21.), and tetravalent (22) dendrimers showed IC50 values of 174, 19, 48, and 18 nM, respectively. Two tetramers showed 120- to similar to 128-fold increased inhibitory properties over the monovalent antigen 6 used as a standard (IC50 2.3 mM). Heterobifunctional glycodendrimer bearing a biotin probe was also prepared for cancer cell labeling.

  DOI：

  10.1021/ja002596w
• 作为产物：
  描述：

  2-羟基-2-[(1-氧代-2-丙烯基)氨基]乙酸 、 丙烯腈 在 硫酸 作用下， 生成 二[(1-氧代-2-丙烯基)氨基]-乙酸
  参考文献：
  名称：

  Schouteeten,A. et al., Bulletin de la Societe Chimique de France, 1978, vol. , p. 248 - 254

  摘要：

  DOI：

文献信息

• Liquid Dispersion Polymer Compositions, Their Preparation And Their Use
  申请人：Ridley Eleanor Bernice

  公开号：US20080275138A1

  公开（公告）日：2008-11-06

  Liquid dispersion polymer compositions which comprise microparticles of a hydrophilic, water soluble or swellable polymer with a neutralization level of from about 25% to about 100%, preferably an acrylic-based polymer, dispersed in a suitable non-aqueous carrier fluid and an oil-in-water surfactant, are useful to prepare microparticulate thickening systems to thicken aqueous or aqueous/organic compositions, particularly for use in personal care and pharmaceutical formulations.

  这种液态分散聚合物组合物包括微粒状的亲水性、水溶性或可溶胀聚合物，其中和水平从约25%到约100%，最好是丙烯酸基聚合物，分散在适当的非水载体液和油包水表面活性剂中。这些组合物可用于制备微粒状增稠系统，用于增稠水性或水性/有机组合物，特别适用于个人护理和制药配方。
• MICROSPHERES CONTAINING THERAPEUTIC AGENTS AND RELATED METHODS OF USE
  申请人：Biosphere Medical, Inc.

  公开号：US20170231915A1

  公开（公告）日：2017-08-17

  Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.

  本文公开了微球、包括微球的组合物以及使用微球的方法。这些微球可以是基本球形的，可以包括单体的共聚物（如丙烯酸单体）和环糊精或其衍生物。这些微球还可以包括治疗剂，如基于铂的药物。
• Hetero-difunctional dimers as building blocks for the synthesis of poly(amidoamine)s with hetero-difunctional chain terminals and their derivatives
  作者：Paolo Ferruti、Nicolò Mauro、Amedea Manfredi、Elisabetta Ranucci

  DOI：10.1002/pola.26325

  日期：2012.12.1

  This article reports on a simple and straightforward preparation method of poly(amidoamine)s (PAAs) with hetero‐difunctional chain ends as well as of several up to now hardly obtainable PAA derivatives of biotechnological interest, such as for instance PAAs of controlled molecular weight and narrow polydispersity mono‐functionalized at one end with an acrylamide group, PAAs with star‐like molecular

  本文报道了一种简单，直接的制备具有杂双功能链末端的聚（酰胺基胺）（PAA）的方法，以及几种迄今难以获得的具有生物技术意义的PAA衍生物，例如分子量受控的PAA。一端具有丙烯酰胺基团的窄单分散功能，具有星形分子结构的PAA，接枝的PAA蛋白偶联物，具有疏水部分的“ like状” PAA偶联物，能够在水性介质中自组装成纳米颗粒。关键步骤是设计由异双功能二聚体（HDD）组成的合适构建基块。特别是，考虑到硬盘驱动器是双的单加成产物秒胺和双丙烯酰胺有望提供已证明具有生物医学潜力的PAA，并以盐酸盐或三氟乙酸盐的形式获得。以这种形式，它们可以在干燥状态下在0-5°C下无限期保持休眠状态，而在室温和水性介质中，它们在pH> 7.5时聚合。上面提到的PAA衍生物的制备不一定涉及杂双功能PAA的初步合成，而是直接在存在相关底物的情况下通过HDD的一锅法聚合而直接实现的。©2012 Wiley Periodicals，Inc
• Structural and thermal studies of the chloro complexes of cobalt, nickel and copper with 2,2-bis(acrylamido)acetic acid and assessment of their suitability as anti-static additives for polyethylene
  作者：J.R. Allan、A.R. Gardner、B. McCloy、W.E. Smith

  DOI：10.1016/0040-6031(92)80156-q

  日期：1992.10

  Abstract The preparation and properties of the complexes of 2,2-bis(acrylamido)acetic acid with cobalt, nickel and copper are described. Spectral, magnetic and solubility studies indicate that the complexes have polymeric octahedral structures. The decomposition of each compound has been studied using thermogravimetry and differential thermal analysis. The complexes, which are hydrated, lose water followed

  摘要 介绍了2,2-双(丙烯酰胺)乙酸与钴、镍、铜的配合物的制备和性能。光谱、磁性和溶解度研究表明配合物具有聚合八面体结构。已使用热重分析法和差热分析法研究了每种化合物的分解。水合的配合物失水，然后有机配体得到金属氧化物。化合物 2,2-双（丙烯酰胺）乙酸及其金属配合物已被研究作为可能的抗静电添加剂，但发现其效果不如商业化合物。然而，有证据表明它们可以产生更持久的抗静电性能。
• Papermaking chemical, method for manufacturing same, and paper containing same
  申请人：Kiyosada Toshitsugu

  公开号：US20050272889A1

  公开（公告）日：2005-12-08

  A novel (meth)acrylamide polymer capable of forming a papermaking chemical exhibiting an excellent paper strengthening effect, drainage improvement effect, retention improvement effect, plybond strength enhancing effect, surface strength enhancing effect, and sizing improvement effect in acid, neutral, or alkaline papermaking systems, as well as a method for manufacturing this polymer, and paper that makes use of this polymer and has excellent bursting strength, internal bond strength, and other such properties is provided. This is a (meth)acrylamide polymer produced by polymerizing a monomer (a) expressed by the following general formula 1, the following monomer (b), and the following monomer (c): (a) general formula 1: (b) a (meth)acrylamide; (c) an ionic monomer other than monomer (a) expressed by general formula 1 above

  提供了一种新型（甲基）丙烯酰胺聚合物，能够形成一种造纸化学品，具有优异的造纸强化效果、排水改善效果、保留改善效果、层压强度增强效果、表面强度增强效果和尺寸稳定性改善效果，适用于酸性、中性或碱性造纸系统，以及制造该聚合物的方法和使用该聚合物的纸张，具有优异的爆裂强度、内部粘合强度和其他类似性能。该聚合物是通过聚合以下通式1所表示的单体（a）、以下单体（b）和以下单体（c）制备的：（a）通式1：（b）（甲基）丙烯酰胺；（c）除通式1所述的单体（a）之外的离子单体。

表征谱图