methyl N,N'-bis(acrylamido)acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl N,N'-bis(acrylamido)acetate
• 英文别名: Methyl 2,2-bis(prop-2-enoylamino)acetate
• 化学式: C₉H₁₂N₂O₄
• 分子量: 212.205
• InChiKey: KGBYWOBFKDOZKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  84.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  巯基乙胺 、 methyl N,N'-bis(acrylamido)acetate 在 N,N-二异丙基乙胺 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以93%的产率得到bis[N,N'-(2-(2-aminoethyl)thioethylamido)]acetate
  参考文献：
  名称：

  Synthesis of N,N‘-bis(Acrylamido)acetic Acid-Based T-Antigen Glycodendrimers and Their Mouse Monoclonal IgG Antibody Binding Properties

  摘要：

  Novel glycodendrimers based on N,N'-bis(acrylamido)acetic acid core with valencies between two and six were synthesized. The breast cancer-associated T-antigen carbohydrate marker, (beta -Gal-(1 -3)-alpha -GalNAc-OR), was then conjugated by (i) 1,4-conjugate addition of thiolated T-antigen to the N-acrylamido dendritic cores and by (ii) amide bond formation between an acid derivative of the T-antigen and the polyamino dendrimers. The protein-binding ability of these new glycodendrimers was fully demonstrated by turbidimetric analysis and by enzyme-linked immunosorbent assay (ELISA) using peanut lectin from Arachis hypogaea and a mouse monoclonal antibody (MAb) FAA-J11 (IgG3). When tested as inhibitors of binding between: MAb and a polymeric form of the T-antigen (T-antigen-co-polyacrylamide) used as a coating antigen, di(17), tetra- (20), hexa- (21.), and tetravalent (22) dendrimers showed IC50 values of 174, 19, 48, and 18 nM, respectively. Two tetramers showed 120- to similar to 128-fold increased inhibitory properties over the monovalent antigen 6 used as a standard (IC50 2.3 mM). Heterobifunctional glycodendrimer bearing a biotin probe was also prepared for cancer cell labeling.

  DOI：

  10.1021/ja002596w
• 作为产物：
  描述：

  甲醇 、 二[(1-氧代-2-丙烯基)氨基]-乙酸 在 氯化亚砜 作用下， 反应 4.0h， 以80%的产率得到methyl N,N'-bis(acrylamido)acetate
  参考文献：
  名称：

  Synthesis of N,N‘-bis(Acrylamido)acetic Acid-Based T-Antigen Glycodendrimers and Their Mouse Monoclonal IgG Antibody Binding Properties

  摘要：

  Novel glycodendrimers based on N,N'-bis(acrylamido)acetic acid core with valencies between two and six were synthesized. The breast cancer-associated T-antigen carbohydrate marker, (beta -Gal-(1 -3)-alpha -GalNAc-OR), was then conjugated by (i) 1,4-conjugate addition of thiolated T-antigen to the N-acrylamido dendritic cores and by (ii) amide bond formation between an acid derivative of the T-antigen and the polyamino dendrimers. The protein-binding ability of these new glycodendrimers was fully demonstrated by turbidimetric analysis and by enzyme-linked immunosorbent assay (ELISA) using peanut lectin from Arachis hypogaea and a mouse monoclonal antibody (MAb) FAA-J11 (IgG3). When tested as inhibitors of binding between: MAb and a polymeric form of the T-antigen (T-antigen-co-polyacrylamide) used as a coating antigen, di(17), tetra- (20), hexa- (21.), and tetravalent (22) dendrimers showed IC50 values of 174, 19, 48, and 18 nM, respectively. Two tetramers showed 120- to similar to 128-fold increased inhibitory properties over the monovalent antigen 6 used as a standard (IC50 2.3 mM). Heterobifunctional glycodendrimer bearing a biotin probe was also prepared for cancer cell labeling.

  DOI：

  10.1021/ja002596w

文献信息

• Papermaking chemical, method for manufacturing same, and paper containing same
  申请人：Kiyosada Toshitsugu

  公开号：US20050272889A1

  公开（公告）日：2005-12-08

  A novel (meth)acrylamide polymer capable of forming a papermaking chemical exhibiting an excellent paper strengthening effect, drainage improvement effect, retention improvement effect, plybond strength enhancing effect, surface strength enhancing effect, and sizing improvement effect in acid, neutral, or alkaline papermaking systems, as well as a method for manufacturing this polymer, and paper that makes use of this polymer and has excellent bursting strength, internal bond strength, and other such properties is provided. This is a (meth)acrylamide polymer produced by polymerizing a monomer (a) expressed by the following general formula 1, the following monomer (b), and the following monomer (c): (a) general formula 1: (b) a (meth)acrylamide; (c) an ionic monomer other than monomer (a) expressed by general formula 1 above

  提供了一种新型（甲基）丙烯酰胺聚合物，能够形成一种造纸化学品，具有优异的造纸强化效果、排水改善效果、保留改善效果、层压强度增强效果、表面强度增强效果和尺寸稳定性改善效果，适用于酸性、中性或碱性造纸系统，以及制造该聚合物的方法和使用该聚合物的纸张，具有优异的爆裂强度、内部粘合强度和其他类似性能。该聚合物是通过聚合以下通式1所表示的单体（a）、以下单体（b）和以下单体（c）制备的：（a）通式1：（b）（甲基）丙烯酰胺；（c）除通式1所述的单体（a）之外的离子单体。
• (METH)ACRYLAMIDE POLYMER, PROCESS FOR PRODUCTION THEREOF, PAPER MAKING CHEMICALS, PAPERS CONTAINING THE SAME
  申请人：Seiko PMC Corporation

  公开号：EP1486515A1

  公开（公告）日：2004-12-15

  A novel (meth)acrylamide polymer capable of forming a papermaking chemical exhibiting an excellent paper strengthening effect, drainage improvement effect, retention improvement effect, plybond strength enhancing effect, surface strength enhancing effect, and sizing improvement effect in acid, neutral, or alkaline papermaking systems, as well as a method for manufacturing this polymer, and paper that makes use of this polymer and has excellent bursting strength, internal bond strength, and other such properties is provided. This is a (meth)acrylamide polymer produced by polymerizing a monomer (a) expressed by the following general formula 1, the following monomer (b), and the following monomer (c): (a) general formula 1: (b) a (meth)acrylamide; (c) an ionic monomer other than monomer (a) expressed by general formula 1 above

  本发明提供了一种新型(甲基)丙烯酰胺聚合物，这种聚合物能够形成一种造纸化学品，在酸性、中性或碱性造纸体系中表现出优异的纸张增强效果、排水改善效果、留着改善效果、层间粘结强度增强效果、表面强度增强效果和施胶改善效果，还提供了制造这种聚合物的方法，以及使用这种聚合物制造的纸张具有优异的耐破度、内结合强度和其他性能。这是一种(甲基)丙烯酰胺聚合物，由以下通式 1 表示的单体(a)、以下单体(b)和以下单体(c)聚合而成： (a) 通式 1： (b) 一种（甲基）丙烯酰胺； (c) 除上述通式 1 所表示的单体(a)以外的离子单体
• US4960923A
  申请人：——

  公开号：US4960923A

  公开（公告）日：1990-10-02
• US5635169A
  申请人：——

  公开号：US5635169A

  公开（公告）日：1997-06-03
• US6107397A
  申请人：——

  公开号：US6107397A

  公开（公告）日：2000-08-22