3-ethoxypropylamine hydrochloride

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-ethoxypropylamine hydrochloride
• 英文别名: 3-Ethoxypropan-1-amine;hydrochloride
• 化学式: C₅H₁₃NO*ClH
• 分子量: 139.625
• InChiKey: GQTHACRJHWOIIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.79
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3-dihydroxyacetone dimer 、 3-ethoxypropylamine hydrochloride 生成 5-hydroxymethyl-3-(3-ethoxypropyl)-1H-imidazole
  参考文献：
  名称：

  Pyrrole derivatives useful for farnesyl transferase inhibitors and their preparations

  摘要：

  本发明涉及一种新型吡咯衍生物，其具有对法尼基转移酶的抑制活性，或其药学上可接受的盐或同分异构体；涉及一种制备该化合物的方法；以及一种制药组合物，如抗癌组合物等，包括该化合物作为活性成分，以及药学上可接受的载体。

  公开号：

  US06511978B1

文献信息

• Pyrimidine derivatives as IL-8 receptor antagonists
  申请人：——

  公开号：US20040087601A1

  公开（公告）日：2004-05-06

  Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I 1 In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, —O—alkyl or —S-alkyl. A representative example is: 2

  含有嘧啶核的化合物及其用于治疗与不适当的白细胞介素-8受体活性相关的疾病和症状的用途已被披露。这些化合物的结构式为I 1 在这些化合物中，Q最好是未取代或取代的杂环烷基；U通常是氢或氟；V最好是氢、卤素、烷基、—O—烷基或—S-烷基。一个代表性的例子是： 2
• Imidazole derivatives having an inhibitory activity for farnesyl transferase and process for preparation thereof
  申请人：LG Chemical Ltd.

  公开号：US06268363B1

  公开（公告）日：2001-07-31

  The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1 and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.

  本发明涉及一种新型咪唑衍生物，其化学式表示为（1），该化合物对法尼基转移酶具有抑制活性，或者其药学上可接受的盐或同分异构体，其中A、n1和Y在规范中有定义；制备化合物（1）的方法；用于制备化合物（1）的中间体；以及包含化合物（1）作为活性成分的药物组合物。
• [EN] IMIDAZOLE DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE AND PROCESS FOR PREPARATION THEREOF<br/>[FR] DERIVES D'IMIDAZOLE A ACTIVITE INHIBITRICE DE FARNESYLE TRANSFERASE ET LEUR PROCEDE DE PREPARATION
  申请人：LG CHEMICAL LTD.

  公开号：WO1999028315A1

  公开（公告）日：1999-06-10

  (EN) The present invention relates to a novel imidazole derivative represented by formula (1) which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof, in which A, n1 and Y are defined in the specification; to a process for preparation of the compound of formula (1); to intermediates which are used in the preparation of the compound of formula (1); and to a pharmaceutical composition comprising the compound of formula (1) as an active ingredient.(FR) La présente invention concerne un nouveau dérivé d'imidazole représenté par la formule (1) présentant une activité inhibitrice contre la farnésyle transférase, ou ses sels ou isomères acceptables sur le plan pharmaceutique, formule dans laquelle A, n1 et Y sont définis dans le description de l'invention; un procédé de préparation du composé de la formule (1); des intermédiaires utilisés dans la préparation du composé de la formule (1); et une composition pharmaceutique comprenant le composé de la formule (1) en tant que principe actif.

  (中) 本发明涉及一种新的咪唑衍生物，其表示为式（1），该衍生物对法尼酰转移酶具有抑制活性，或其药学上可接受的盐或异构体，其中A、n1和Y在规范中定义；制备式（1）化合物的方法；用于制备式（1）化合物的中间体；以及包含式（1）化合物作为活性成分的药物组合物。
• .beta.-Adrenergic blocking agents. 17. 1-Phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols
  作者：L. H. Smith、H. Tucker

  DOI：10.1021/jm00222a022

  日期：1977.12

  The synthesis is described of a series of derivatives of 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propranols. The compounds were investigated for their beta-adrenoceptor blocking properties and many showed a surprising degree of cardioselectivity when tested in vivo in anesthetized cats for their effects on an isoproterenol-induced tachycardia and depressor response. The structure-activity relationship shown by this series of compounds is related to that of known cardioselective analogues and a possible reason for their cardioselectivity is discussed.
• IMIDAZOLE DERIVATIVES HAVING AN INHIBITORY ACTIVITY FOR FARNESYL TRANSFERASE AND PROCESS FOR PREPARATION THEREOF
  申请人：LG CHEMICAL LIMITED

  公开号：EP1045846B1

  公开（公告）日：2003-05-02