4-bromo-2-fluoro-1-methoxymethoxybenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-bromo-2-fluoro-1-methoxymethoxybenzene
• 英文别名: 1-bromo-3-fluoro-4-(methoxymethoxy)benzene；4-bromo-2-fluoro-1-(methoxymethoxy)benzene；3-fluoro-4-methoxymethoxybromobenzene；4-Bromo-2-fluoro-1-methoxymethoxy-benzene
• 化学式: C₈H₈BrFO₂
• 分子量: 235.053
• InChiKey: GDVPFBUPOUTQPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-bromo-2-fluoro-1-methoxymethoxybenzene 在 bis-triphenylphosphine-palladium(II) chloride 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 potassium acetate 、 potassium carbonate 作用下， 以 乙醇 、 水 、 二甲基亚砜 为溶剂， 反应 2.75h， 生成 ethyl 8-(3-fluoro-4-hydroxyphenyl)-1,6-naphthyridine-2-carboxylate
  参考文献：
  名称：

  CYCLIC COMPOUND HAVING SUBSTITUTED PHENYL GROUP

  摘要：

  公开号：

  EP2418203B1
• 作为产物：
  描述：

  4-溴-2-氟苯酚 、 氯甲基甲基醚 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 25.0h， 以57%的产率得到4-bromo-2-fluoro-1-methoxymethoxybenzene
  参考文献：
  名称：

  Synthesis, Phase-transition Behaviors, and Birefringence Properties of Fluorinated Diphenyl–Diacetylene Derivatives

  摘要：

  我们设计了基于氟化二苯基-二炔的液晶（LC）分子，这些液晶分子在接近室温时表现出外消旋型向列相。这些液晶分子还显示出与其非氟化类似物相似的高双折射率（Δn ≈ 0.35）。向液晶分子中引入氟原子可以降低相变温度，而不降低双折射率。

  DOI：

  10.1246/cl.140779

文献信息

• Polymeric compounds, and liquid crystal element using the same
  申请人：Sharp Kabushiki Kaisha

  公开号：US05645760A1

  公开（公告）日：1997-07-08

  The polymeric compound of this invention is represented by the following general formula (I): ##STR1## wherein A represents a hydrogen atom or ##STR2## B represents a hydrogen atom or ##STR3## each of X.sub.1 and X.sub.2 represents independently a hydrogen atom or a methyl group, each of m and n represents independently an integer of 0 to 14, each of p and q represents independently 0 or 1, and each of Y1, Y.sub.2, Y.sub.3, and Y.sub.4, represents independently a hydrogen atom or a fluorine atom, with the proviso that both A and B are not hydrogen atoms, p is 0 when m is 0, and q is 0 when n is 0. The liquid crystal display element of this invention includes a pair of substrates oppositely disposed with a gap therebetween, and a liquid crystal layer placed in said gap, at least one of said substrates being transparent, and said liquid crystal layer having a liquid crystal region, and a polymer wall surrounded by said liquid crystal region, wherein said liquid crystal layer includes a liquid crystal material, a polymeric polymer material, and the above-described polymeric compound. The liquid crystal display element prepared from the polymeric compound of this invention does not cause disclination lines, and has bright characteristics in the absence of an electric voltage.

  本发明的聚合物化合物由以下通式（I）表示：##STR1## 其中，A代表氢原子或##STR2## B代表氢原子或##STR3## X.sub.1和X.sub.2分别独立地表示氢原子或甲基基团，m和n分别独立地表示0至14的整数，p和q分别独立地表示0或1，Y1、Y.sub.2、Y.sub.3和Y.sub.4分别独立地表示氢原子或氟原子，但A和B均不是氢原子，当m为0时，p为0，当n为0时，q为0。本发明的液晶显示元件包括一对相对放置的基板，之间有间隙，并且在该间隙中放置了液晶层，其中至少一个基板是透明的，且该液晶层具有液晶区域和被该液晶区域包围的聚合物墙，其中该液晶层包括液晶材料、聚合物材料和上述聚合物化合物。从本发明的聚合物化合物制备的液晶显示元件不会产生断线，且在无电压的情况下具有明亮的特性。
• Cyclobutanecarboxylic acid derivatives and liquid crystalline
  申请人：Kanto Kagaku Kabushiki Kaisha

  公开号：US05545747A1

  公开（公告）日：1996-08-13

  An optically inactive cyclobutanecarboxylic acid derivative of the general formula ##STR1## wherein R.sup.1 is a hydrogen atom or a straight or branched chain alkyl group having 1-14 carbon atoms, R.sup.2 is a straight or branched chain alkyl group having 1-14 carbon atoms, X.sup.1 and X.sup.2 independently represent hydrogen or fluorine atoms, as well as a liquid crystalline composition containing at least one such derivative.

  一种光学不活性的环丁基甲酸衍生物，其通式为## STR1 ##，其中R1是氢原子或具有1-14个碳原子的直链或支链烷基，R2是具有1-14个碳原子的直链或支链烷基，X1和X2独立表示氢或氟原子，以及至少含有一种这样的衍生物的液晶组合物。
• 3,3′-difluorobiphenyl derivatives, liquid crystal compositions, and liquid crystal display elements
  申请人：Chisso Corporation

  公开号：US06197217B1

  公开（公告）日：2001-03-06

  Liquid crystalline compounds which exhibit a negative dielectric anisotropy value, have an extremely high voltage holding ratio and a low threshold voltage, are small in their dependency on temperature, hardly exhibit smectic phase, and are excellent in miscibility with other liquid crystal materials at the same time; liquid crystal compositions comprising the compound; and liquid crystal display devices fabricated by using the liquid crystal composition are provided; the liquid crystalline compounds being specific 3,3′-difluorobiphenyl derivatives expressed by the following general formula (1):

  提供具有负电介质各向异性值的液晶化合物，具有极高的电压保持比和低的阈值电压，对温度的依赖性小，几乎不表现出液晶相，同时与其他液晶材料混合优秀的液晶组合物；液晶组合物包括该化合物；以及通过使用该液晶组合物制造的液晶显示装置。该液晶化合物为以下通式（1）所表示的特定3,3'-二氟联苯衍生物。
• Receptor Function Regulation Agent
  申请人：Fukatsu Kohji

  公开号：US20080167378A1

  公开（公告）日：2008-07-10

  An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.

  提供了一种用于调节14273受体功能的药物代理，可用作预防或治疗糖尿病、高脂血症等疾病。该调节14273受体功能的药物代理包含一种含有芳香环和能释放阳离子的基团的化合物。
• BICYCLIC HETEROCYCLIC DERIVATIVE
  申请人：Nakahira Hiroyuki

  公开号：US20110190278A1

  公开（公告）日：2011-08-04

  The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R 1a is halogen, etc.; R 1m is H, etc.; G 1 is —N(R 1b )—, etc.; G 2 is —CO—, etc.; G 3 is —C(R 1c )(R 1d )—, etc.; G 4 is oxygen, etc.; R 1b is optionally substituted C 1-6 alkyl, etc.; R 1c and R 1d are independently the same or different, H, etc.; R 3 is H, optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3 c and R 3d are independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]

  本发明涉及以下式（I）的化合物或其药学上可接受的盐，其可用作肾素抑制剂。[其中，R1a是卤素等；R1m是H等；G1是—N（R1b）—等；G2是—CO—等；G3是—C（R1c）（R1d）—等；G4是氧等；R1b是可选取代的C1-6烷基等；R1c和R1d独立选择为H等；R3是H、可选取代的C1-6烷基等；R3a、R3b、R3c和R3d独立选择为相同或不同的基团：-A-B（其中A是单键等，B是H等）等；n为1等。]