3-hydroxy-2-methylhexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 3-hydroxy-2-methylhexanoic acid
• 英文别名: anti-3-hydroxy-2-methylhexanoic acid；(2S,3S)-3-hydroxy-2-methylhexanoic acid
• 化学式: C₇H₁₄O₃
• 分子量: 146.186
• InChiKey: UBEKFGMRKUQZGX-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-hydroxy-2-methylhexanoic acid 在 吡啶 、 对甲苯磺酰氯 作用下， 生成 3-Methyl-4-propyloxetan-2-one
  参考文献：
  名称：

  Sakai, Naoko; Ageishi, Satoru; Isobe, Hiroshi, Journal of the Chemical Society. Perkin transactions I, 2000, # 1, p. 71 - 78

  摘要：

  DOI：
• 作为产物：
  描述：

  己酸,3-羟基-2-亚甲基-,甲基酯 在 palladium on activated charcoal lithium hydroxide 、 氢气 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 反应 20.0h， 生成 3-hydroxy-2-methylhexanoic acid
  参考文献：
  名称：

  Diastereoselectivity in heterogeneous catalytic hydrogenation of Baylis–Hillman adducts. Total synthesis of (±)-sitophilate

  摘要：

  We describe herein a highly diastereoselective total synthesis of racemic sitophilate, based on the results obtained in a diastereoselective heterogeneous catalytic hydrogenation reaction of a set of Baylis-Hillman adducts originating from aliphatic aldehydes. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(01)00647-0

文献信息

• anti-Selective enolboration–aldolization of propanoic acid
  作者：P. Veeraraghavan Ramachandran、Prem B. Chanda、Barnabas Otoo

  DOI：10.1016/j.tetlet.2013.12.048

  日期：2014.2

  A systematic examination of enolboration-aldolization of propanoic acid has led to an efficient synthesis of anti-beta-hydroxy-alpha-methyl carboxylic acids in consistently high yields and diastereoselectivities by using B-bromodicyclohexylborane as the enolization reagent and triethylamine as the base. (C) 2014 Published by Elsevier Ltd.
• BACTERIUM PRODUCING A PRODUCT OF A REACTION CATALYZED BY A PROTEIN HAVING 2-OXOGLUTARATE-DEPENDENT ENZYME ACTIVITY AND A METHOD FOR MANUFACTURING THE PRODUCT
  申请人：Smirnov Sergey Vasilievich

  公开号：US20100330622A1

  公开（公告）日：2010-12-30

  A method for manufacturing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity such as (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using a bacterium transformed with a DNA fragment containing a gene coding for a protein having 2-oxoglutarate-dependent enzyme activity such as L-isoleucine dioxygenase activity; and wherein said bacterium has the ability to produce a product such as (2S,3R,4S)-4-hydroxy-L-isoleucine.
• US8114651B2
  申请人：——

  公开号：US8114651B2

  公开（公告）日：2012-02-14
• US8524476B2
  申请人：——

  公开号：US8524476B2

  公开（公告）日：2013-09-03
• [EN] TREATMENT OF ENERGY UTILIZATION DISEASE<br/>[FR] TRAITEMENT D'UNE MALADIE DE L'UTILISATION D'ÉNERGIE
  申请人：SUMMIT CORP PLC

  公开号：WO2009103953A1

  公开（公告）日：2009-08-27

  Described are compositions comprising imino sugar acids for the treatment of energy utilization disease (e.g. metabolic syndrome, including any disease or disorder associated therewith, for example central obesity, elevated levels of triglycerides and diabetes, including type 1 diabetes, type 2 diabetes and insulin resistance), processes for producing said compositions from various plant sources, together with various products, compounds, compositions, medical uses and methods based thereon.