N-[(5-chloro-8-hydroxyquinolin-7-yl)thiophen-2-ylmethyl]-3-phenylpropanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[(5-chloro-8-hydroxyquinolin-7-yl)thiophen-2-ylmethyl]-3-phenylpropanamide
• 英文别名: N-[(5-chloro-8-hydroxyquinolin-7-yl)(2-thienyl)methyl]-3-phenylpropanamide；N-[(5-chloro-8-hydroxy-7-quinolyl)-(2-thienyl)methyl]-3-phenyl-propanamide；N-[(5-chloro-8-hydroxyquinolin-7-yl)-thiophen-2-ylmethyl]-3-phenylpropanamide
• 化学式: C₂₃H₁₉ClN₂O₂S
• 分子量: 422.935
• InChiKey: SRLJNSQTNHJWPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  90.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-噻吩甲醛 、 3-苯基丙酰胺 、 5-氯-8-羟基喹啉 以 neat (no solvent) 为溶剂， 反应 0.5h， 生成 N-[(5-chloro-8-hydroxyquinolin-7-yl)thiophen-2-ylmethyl]-3-phenylpropanamide
  参考文献：
  名称：

  Small molecule activators of mitochondrial function

  摘要：

  通过暴露细胞或治疗受试者以一般公式化合物或组合物，描述了改善线粒体功能、减少铁积累和/或减少氧化应激的方法，这些方法有益于治疗例如弗里德雷希共济失调、正常衰老以及各种神经退行性疾病如阿尔茨海默病和帕金森病等疾病。此外，这些化合物可用作探针，用于识别线粒体代谢缺陷、线粒体铁积累、细胞应激以及其他线粒体疾病，并有助于识别能够克服这些缺陷的活性化合物。

  公开号：

  US09695157B2

文献信息

• SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION
  申请人：Wilson Robert B.

  公开号：US20120041023A1

  公开（公告）日：2012-02-16

  Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula (I) are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.
• US9000009B2
  申请人：——

  公开号：US9000009B2

  公开（公告）日：2015-04-07
• US9695157B2
  申请人：——

  公开号：US9695157B2

  公开（公告）日：2017-07-04
• [EN] SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION<br/>[FR] ACTIVATEURS DE PETITES MOLÉCULES DE LA FONCTION MITOCHONDRIALE
  申请人：UNIV PENNSYLVANIA

  公开号：WO2010068767A1

  公开（公告）日：2010-06-17

  Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula (I) are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.
• Small molecule activators of mitochondrial function
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US09695157B2

  公开（公告）日：2017-07-04

  Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general formula are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial diseases and helping to identify compounds active in overcoming such defects.

  通过暴露细胞或治疗受试者以一般公式化合物或组合物，描述了改善线粒体功能、减少铁积累和/或减少氧化应激的方法，这些方法有益于治疗例如弗里德雷希共济失调、正常衰老以及各种神经退行性疾病如阿尔茨海默病和帕金森病等疾病。此外，这些化合物可用作探针，用于识别线粒体代谢缺陷、线粒体铁积累、细胞应激以及其他线粒体疾病，并有助于识别能够克服这些缺陷的活性化合物。