1-(2-methylhexyl)pyrrolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-methylhexyl)pyrrolidine
• 英文别名: 1-(2-Methylhexyl)pyrrolidine
• 化学式: C₁₁H₂₃N
• 分子量: 169.31
• InChiKey: HKDFLZHEERXRDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 1-己烯 、 一氧化碳 在 {Rh(COD)Cl}2(Ph2POC6H4OPPh2) 、 氢气 作用下， 以 四氢呋喃 为溶剂， 80.0 ℃ 、3.0 MPa 条件下， 反应 6.0h， 生成 1-庚基吡咯烷 、 1-(2-methylhexyl)pyrrolidine
  参考文献：
  名称：

  使用简单高效的Rh-次亚膦酸酯络合物催化剂进行烯烃的选择性氢氨基甲基化

  摘要：

  各种烯烃与伯胺和仲胺的氢氨基甲基化反应是使用简单有效的铑-次亚膦酸酯络合物催化剂进行的。研究了各种反应参数的影响，包括温度，压力，催化剂负载量，时间和溶剂的影响。本方案是一般的，具有广泛的底物适用性，用于合成重要种类的脂族胺和芳基乙胺。在温和的反应条件下，以非常好的底物/催化剂摩尔比（周转数2500）实现了对胺的高活性和选择性。版权所有©2013 John Wiley＆Sons，Ltd.

  DOI：

  10.1002/aoc.3046

文献信息

• Psychotropic agents and uses thereof
  申请人：LB PHARMACEUTICALS INC.

  公开号：US10259786B2

  公开（公告）日：2019-04-16

  Novel amisulpride derivatives and pharmaceutical compositions thereof are disclosed. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may have better membrane permeability compared to amisulpride. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for antagonizing dopamine and/or serotonin (e.g., 5-HT2a) and/or α2 receptor in a subject. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for treating one or more conditions responsive to modulation of dopamine and/or serotonin (e.g., 5-HT2a) and/or α2 receptor in a subject. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for treating one or more disorders associated with an abnormality in levels of dopamine and/or serotonin in the brain.

  本研究公开了新型氨磺必利衍生物及其药物组合物。与阿米舒必利相比，本文公开的阿米舒必利衍生物或其药物组合物可能具有更好的膜渗透性。本文公开的氨磺必利衍生物或其药物组合物可用于拮抗受试者体内的多巴胺和/或5-羟色胺（如5-HT2a）和/或α2受体。本文公开的氨磺必利衍生物或其药物组合物可用于治疗受试者体内一种或多种对多巴胺和/或5-羟色胺（如5-HT2a）和/或α2受体调节有反应的病症。本文公开的氨磺必利衍生物或其药物组合物可用于治疗与大脑中多巴胺和/或5-羟色胺水平异常相关的一种或多种疾病。
• Rhodium exchanged ETS-10 and ETS-4: Efficient heterogeneous catalyst for hydroaminomethylation
  作者：N. Sudheesh、Ram S. Shukla

  DOI：10.1016/j.apcata.2014.01.002

  日期：2014.3

  Rhodium exchanged titanosilicates (ETS-10 and ETS-4) were synthesized and found to be efficient and stable catalysts for hydroaminomethylation reaction. The catalyst was highly active and selective towards amine product within lower reaction time of 4 h. 1-Hexene and pyrrolidine were taken as representative substrates for parametric variations using Rh-ETS-10. The increase in pyrrolidine ratio gave some significant information showing a decrease in conversion with increased selectivity. The reason may be the competition between pyrrolidine and 1-hexene for coordination sites in rhodium and which prevents the beta-hydride elimination. The ratios of H-2 and CO have influenced hydroaminomethylation and the best performance was in the CO: H-2 ratio of 1:4 under the studied conditions. The initial rate of formation of amine was double than that of isomerization of 1-hexene. The Rh cluster like complex was formed on treating the catalyst with syn gas. A homogenous-heterogeneous dual nature of Rh was found during hydroaminomethylation. The catalyst was effectively recycled for three times without much loss in its activity and selectivity. (C) 2014 Elsevier B.V. All rights reserved.
• Rhodium complex encapsulated functionalized hexagonal mesoporous silica for heterogeneous hydroaminomethylation
  作者：N. Sudheesh、Ram S. Shukla

  DOI：10.1016/j.apcata.2012.12.021

  日期：2013.2

  HRh(CO)(PPh3)(3) complex was encapsulated into the pores of amino functionalized hexagonal mesoporous silica. The catalyst was characterized by physico-chemical techniques like P-XRD, P-31-CPMAS NMR, FT-IR, SEM, ICP and N-2 adsorption analysis. The catalyst was active for hydroaminomethylation and a variety of alkenes and amines were used as reactants for hydroaminomethylation. The catalyst afforded to achieve 100% conversion with high (>95%) selectivity to corresponding amines. Parametric variations were performed by taking 1-hexene and morpholine as representative reactants for the study of catalyst amount, temperature, pressure and 1-hexene:morpholine ratio. Significant amounts of aldehydes and enamines were observed during the course of the reaction indicating that there could be two possible rate determining steps. The catalyst was effectively recycled up to five times without much loss in its activity and selectivity. (C) 2012 Elsevier B.V. All rights reserved.
• PSYCHOTROPIC AGENTS AND USES THEREOF
  申请人：LB PHARMACEUTICALS INC.

  公开号：US20180155282A1

  公开（公告）日：2018-06-07

  Novel amisulpride derivatives and pharmaceutical compositions thereof are disclosed. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may have better membrane permeability compared to amisulpride. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for antagonizing dopamine and/or serotonin (e.g., 5-HT2a) and/or α2 receptor in a subject, either individually or in combination with other CNS active agents. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for treating one or more conditions responsive to modulation of dopamine and/or serotonin (e.g., 5-HT2a) and/or α2 receptor in a subject, either individually or in combination with other CNS active agents. The amisulpride derivative disclosed herein or a pharmaceutical composition thereof may be used for treating one or more disorders associated with an abnormality in levels of dopamine and/or serotonin in the brain, either individually or in combination with other CNS active agents.