3-aminopropylcinnamate hydrochloride

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-aminopropylcinnamate hydrochloride
• 英文别名: 3-aminopropyl (E)-3-phenylprop-2-enoate;hydrochloride
• 化学式: C₁₂H₁₅NO₂*ClH
• 分子量: 241.718
• InChiKey: QPVUUCPUJOYZQQ-USRGLUTNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.01
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  52.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-aminopropylcinnamate hydrochloride 、 hyaluronic acid 生成 3APC-HA
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• PHOTOREACTIVE POLYSACCHARIDE, PHOTOCROSSLINKED POLYSACCHARIDE PRODUCT AND METHOD OF MAKING SAME AND MEDICAL MATERIALS MADE FROM THE CROSSLINKED POLYSACCHARIDE
  申请人：Sato Tomoya

  公开号：US20060057098A1

  公开（公告）日：2006-03-16

  A photoreactive polysaccharide which comprises a polysaccharide bound to a glycidyl ester via a covalent bond, a photocrosslinked-polysaccharide prepared by using the photoreactive polysaccharide, and medical products comprising the photocrosslinked-polysaccharide.

  一种光反应性多糖，包括通过共价键与环氧丙烯酯结合的多糖，使用该光反应性多糖制备的光交联多糖，以及包含光交联多糖的医疗产品。
• DRUG-INTRODUCED PHOTO-CROSSLINKED HYALURONIC ACID DERIVED GEL
  申请人：Miyamoto Kenji

  公开号：US20090118348A1

  公开（公告）日：2009-05-07

  A drug-introduced photo-crosslinked hyaluronic acid derived gel which is a photo-crosslinked hyaluronic acid gel into which a drug is introduced through a covalent bond, and has characteristics that are capable of extruding from an injection device. The drug-introduced photo-cross-linked hyaluronic acid derived gel is capable of extruding, for example, by an injection needle of 20 to 25 gauge with a pressure of 0.5 to 5 kg/cm 2 .

  一种药物引入的光交联透明质酸衍生凝胶，该凝胶是一种药物通过共价键引入的光交联透明质酸凝胶，具有能够从注射装置中挤出的特性。例如，20至25号规格的注射针以0.5至5 kg/cm2的压力，能够将该药物引入的光交联透明质酸衍生凝胶挤出。
• Photocurable hyaluronic acid derivative and process for producing the same, and photocured crosslinked hyaluronic acid derivative and medical material using the same
  申请人：Seikagaku Corporation

  公开号：EP1217008A1

  公开（公告）日：2002-06-26

  A photocurable hyaluronic acid derivative of the present invention comprises hyaluronic acid and a photoreactive crosslinking group bonded thereto, wherein a 1.0 wt. % aqueous solution of the photocurable hyaluronic acid derivative obtained by dissolving the solid photocurable hyaluronic acid derivative in an aqueous solvent, is capable of passing through a porous filter having a pore size of 0.45 µm and a diameter of 25 mm at a rate of not less than 2 ml/minute at 24°C under a pressure of 5.0 Kg/cm2; and a process for producing the photocurable hyaluronic acid derivative; and a photocured crosslinked-hyaluronic acid derivative; a medical material using the photoreactive hyaluronic acid derivative and a medical material using the photocured crosslinked-hyaluronic acid derivative.

  本发明的一种光固化透明质酸衍生物包括透明质酸和与其键合的光活性交联基团，其中通过将固体光固化透明质酸衍生物溶解在水性溶剂中得到的光固化透明质酸衍生物的1.0重量％水溶液，能够在24°C、压力为5.0千克/平方厘米的条件下通过孔径为0.45微米、直径为25毫米的多孔过滤器，在24℃、压力为5.0Kg/cm2的条件下以不小于2毫升/分钟的速率通过；以及一种生产光固化透明质酸衍生物的工艺；和一种光固化交联-透明质酸衍生物；一种使用光固化透明质酸衍生物的医用材料和一种使用光固化交联-透明质酸衍生物的医用材料。
• POLYSACCHARIDE PSEUDO-SPONGE
  申请人：SEIKAGAKU CORPORATION

  公开号：EP1666503A1

  公开（公告）日：2006-06-07

  There is provided a photocrosslinked polysaccharide exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength. The polysaccharide pseudo-sponge is produced by a crosslinking reaction of a photoreactive polysaccharide obtained by introducing a photoreactive group into a polysaccharide, and exhibits a low swelling property and a blue dextran-low dyeaffinity which satisfy the following properties (I) and (II), respectively: (I) a swelling ratio of not more than 125% as calculated from the values measured by immersing a test specimen having a thickness of 1 mm, a length of 10 mm and a width of 10 mm, and a solvent content of 96% by weight, in water for injection at room temperature for 1 hour, according to the following formula: Swelling ratio=(S2-S1)/S1}×100 wherein S1 represents an area of the test specimen before the immersion, and S2 is an area of the test specimen after the immersion, in which the area is calculated from the length and width of the test specimen; and (II) an absorbance of not more than 0.15 at a wavelength of 620 nm as measured with respect to an aqueous solution containing 0.67% by weight of a polysaccharide which is prepared by immersing a test specimen having a thickness of 1 mm, a length of 20 mm and a width of 10 mm, and a solvent content of 96% by weight, in an aqueous solution containing 0.5 g/mL of blue dextran having a weight-average molecular weight of 2,000,000, and then subjecting the test specimen to water-washing and hydrolysis.

  本发明提供了一种光交联多糖，在保持适当强度的同时，具有低膨胀性和高体内降解能力。该多糖假海绵是通过在多糖中引入光活性基团而得到的光活性多糖的交联反应制得的，具有低膨胀性和低染料亲和性的蓝色葡聚糖，分别满足以下特性（I）和（II）： (I) 将厚度为 1 毫米、长度为 10 毫米、宽度为 10 毫米、溶剂含量为 96% （按重量计）的试样在室温注射用水中浸泡 1 小时后测得的膨胀率不超过 125%，按下式计算：膨胀率=(S2-S1)/S1}×100 其中 S1 代表浸泡前试样的面积，S2 是浸泡后试样的面积，其中面积是根据试样的长度和宽度计算得出的；以及 (II) 相对于含有 0.67%（按重量计）多糖的水溶液，在 620 纳米波长处测得的吸光度不超过 0.15，该多糖是将厚度为 1 毫米、长度为 20 毫米、宽度为 10 毫米、溶剂含量为 96%（按重量计）的试样浸入含有 0.5 克/毫升重量平均分子量为 2,000,000 的蓝色葡聚糖的水溶液中，然后将试样进行水洗和水解。
• NUCLEUS PULPOSUS FILLER
  申请人：SEIKAGAKU CORPORATION

  公开号：EP1759719A1

  公开（公告）日：2007-03-07

  The present invention provides a nucleus pulposus filler or the like which is to be packed into an area in deformed intervertebral disc wherein normal nucleus should be located and can be stabley maintained for a long time. More preferably, the present invention provides a nucleus pulposus filler comprising a crosslinked chondroitin sulfate as an active ingredient. The photocrosslinked chondroitin sulfate is preferably the following one: a photocrosslinked chondroitin sulfate obtainable by freezing a photoreactive chondroitin sulfate-containing solution comprising: a photoreactive chondroitin sulfate to which a photoreactive group is bound; an aqueous solvent capable of dissolving the photoreactive chondroitin sulfate; and any one substance selected from the group consisting of an alcohol having aqueous solvent miscibility, a surfactant, and a cheleting agent; irradiating the resulting frozen product with light; and then melting the frozen product. The filler can be provided as a kit by packing it into a container from which the filler can be pushed out.

  本发明提供了一种髓核填料或类似物，它可填入变形椎间盘中正常髓核所在的区域，并可长期稳定地保持。更优选地，本发明提供了一种髓核填料，其活性成分包括交联硫酸软骨素。光交联硫酸软骨素最好是以下一种：通过冷冻含有光活性硫酸软骨素的溶液获得的光交联硫酸软骨素，该溶液包括：光活性硫酸软骨素，其上结合有光活性基团；能够溶解光活性硫酸软骨素的水性溶剂；以及任选的一种物质，该物质选自由水性溶剂混溶性的醇、表面活性剂和螯合剂组成的组；用光照射所得到的冷冻产品；然后熔化冷冻产品。填料可作为成套工具提供，方法是将其装入容器中，然后从容器中推出填料。