1-(4-(1,3-oxathiolan-2-yl)phenyl)ethanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-(1,3-oxathiolan-2-yl)phenyl)ethanone
• 英文别名: 1-[4-(1,3-Oxathiolan-2-yl)phenyl]ethanone
• 化学式: C₁₁H₁₂O₂S
• 分子量: 208.281
• InChiKey: NBIDJJGREPWHOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-乙酰苯甲醛 、 2-巯基乙醇 在 2-溴-1,2-苯并异噻唑-3(2H)-酮 1,1-二氧化物 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以97%的产率得到1-(4-(1,3-oxathiolan-2-yl)phenyl)ethanone
  参考文献：
  名称：

  An efficient method for the oxathioacetalization of carbonyl compounds using N-bromosaccharin as a catalyst

  摘要：

  A mild and highly chemoselective method for the preparation of oxathiolane from aliphatic and aromatic aldehydes and ketones with 2-mercaptoethanol in the presence of catalytic amount of N-bromosaccharin at room temperature is reported. (C) 2012 Heshmatollah Alinezhad. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2012.06.007

文献信息

• Indium Trifluoromethanesulfonate as a Mild and Chemoselective Catalyst for the Conversion of Carbonyl Compounds into 1,3-Oxathiolanes
  作者：Tsuneo Sato、Kiyoshi Kazahaya、Nao Hamada、Shinya Ito

  DOI：10.1055/s-2002-33541

  日期：——

  An efficient method for the preparation of 1,3-oxathiolanes from aldehydes and ketones with 2-mercaptoethanol in the presence of a catalytic amount of indium trifluoromethanesulfonate is reported.

  报道了在催化量的三氟甲磺酸铟存在下，用 2-巯基乙醇从醛和酮制备 1,3-氧杂硫杂环戊烷的有效方法。
• Bandgar; Bettigeri, Sampada V., Journal of Chemical Research, 2004, # 6, p. 389 - 391
  作者：Bandgar、Bettigeri, Sampada V.

  DOI：——

  日期：——
• An efficient method for the oxathioacetalization of carbonyl compounds using N-bromosaccharin as a catalyst
  作者：Heshmatollah Alinezhad、Shahrouz Fallahi

  DOI：10.1016/j.cclet.2012.06.007

  日期：2012.8

  A mild and highly chemoselective method for the preparation of oxathiolane from aliphatic and aromatic aldehydes and ketones with 2-mercaptoethanol in the presence of catalytic amount of N-bromosaccharin at room temperature is reported. (C) 2012 Heshmatollah Alinezhad. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.