(Z)-3-(1H-indol-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (Z)-3-(1H-indol-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile
• 英文别名: (Z)-3-(1H-indol-2-yl)-2-(3,4,5-trimethoxyphenyl)prop-2-enenitrile
• 化学式: C₂₀H₁₈N₂O₃
• 分子量: 334.375
• InChiKey: XTHURULJPZSEPP-OQLLNIDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  67.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z)-3-(1H-indol-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile 、 三正丁基叠氮化锡 以 邻二甲苯 、 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 生成
  参考文献：
  名称：

  新型高效的叠氮化三丁基锡介导的氰基苯甲酸酯合成1 H-四唑基苯甲酸酯

  摘要：

  建立了一种新颖且有效的路线来合成一系列（Z）-5-（2-（杂芳基-2-基）和（Z）-5-（3-（杂芳基-3-基）-1- （苯）乙烯基）-1 H-四唑（分别为3a - g和6a - f），它们来自氰基茂金属类似物，其中包含苯并[ b ]噻吩，苯并[ b ]呋喃和吲哚基团，使用三丁基叠氮化锡作为路易斯酸。叠氮化物的3，3-偶极[3 + 2]环加成到氰基茂金属前体分子的氰基上可提供相应四唑基茂金属类似物的良好产率，并且构成简单且成本有效的方法。

  DOI：

  10.1016/j.tetlet.2016.03.040
• 作为产物：
  描述：

  1H-吲哚-2-甲醛 、 3,4,5-三甲氧基苯乙腈 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 (Z)-3-(1H-indol-2-yl)-2-(3,4,5-trimethoxyphenyl)acrylonitrile
  参考文献：
  名称：

  Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents

  摘要：

  A series of heterocyclic combretastatin analogues have been synthesized and evaluated for their anti-cancer activity against a panel of 60 human cancer cell lines. The most potent compounds were two 3,4,5-trimethoxy phenyl analogues containing either an (Z)-indol-2-yl (8) or (Z)-benzo[b]furan-2-yl (12) moiety; these compounds exhibited GI(50) values of <10 nM against 74% and 70%, respectively, of the human cancer cell lines in the 60-cell panel. Compounds 8, and 12 and two previously reported compounds in the same structural class, i.e. 29 and 31, also showed potent anti-leukemic activity against leukemia MV4-11 cell lines with LD50 values = 44 nM, 47 nM, 18 nM, and 180 nM, respectively. From the NCI anti-cancer screening results and the data from the in vitro toxicity screening on cultured AML cells, seven compounds: 8, 12, 21, 23, 25, 29 and 31 were screened for their in vitro inhibitory activity on tubulin polymerization in MV4-11 AML cells; at 50 nM, 8 and 29 inhibited polymerization of tubulin by >50%. The binding modes of the three most active compounds (8, 12 and 29) to tubulin were also investigated utilizing molecular docking studies. All three molecules were observed to bind in the same hydrophobic pocket at the interface of alpha- and beta-tubulin that is occupied by colchicine, and were stabilized by van der Waals' interactions with surrounding tubulin residues. The results from the tubulin polymerization and molecular docking studies indicate that compounds 8 and 29 are the most potent anti-leukemic compounds in this structural class, and are considered lead compounds for further development as anti-leukemic drugs. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.12.050

文献信息

• [EN] METHODS OF PROTECTING AGAINST NEURODEGENERATION<br/>[FR] PROCÉDÉS DE PROTECTION CONTRE LA NEURODÉGÉNÉRESCENCE
  申请人：BIOVENTURES LLC

  公开号：WO2018144910A1

  公开（公告）日：2018-08-09

  The disclosure provides a method of preventing or reducing protein aggregates using combretastatin-A4 (CA4) or an analog thereof. The disclosure also provides methods of reducing the risk, delaying the onset, delaying or slowing the progression, or reversing the signs or symptoms of a neurodegenerative (or other age-progressive) disease using a combretastatin-A4 (CA4) or an analog thereof. The combretastatin-A4 (CA4) or an analog thereof may bind glial fibrillary acidic protein (GFAP). The combretastatin-A4 (CA4) or an analog thereof is described by compounds of Formula (I).
• Synthesis, anticancer activity and molecular docking studies on a series of heterocyclic trans-cyanocombretastatin analogues as antitubulin agents
  作者：Narsimha Reddy Penthala、Hongliang Zong、Amit Ketkar、Nikhil Reddy Madadi、Venumadav Janganati、Robert L. Eoff、Monica L. Guzman、Peter A. Crooks

  DOI：10.1016/j.ejmech.2014.12.050

  日期：2015.3

  A series of heterocyclic combretastatin analogues have been synthesized and evaluated for their anti-cancer activity against a panel of 60 human cancer cell lines. The most potent compounds were two 3,4,5-trimethoxy phenyl analogues containing either an (Z)-indol-2-yl (8) or (Z)-benzo[b]furan-2-yl (12) moiety; these compounds exhibited GI(50) values of <10 nM against 74% and 70%, respectively, of the human cancer cell lines in the 60-cell panel. Compounds 8, and 12 and two previously reported compounds in the same structural class, i.e. 29 and 31, also showed potent anti-leukemic activity against leukemia MV4-11 cell lines with LD50 values = 44 nM, 47 nM, 18 nM, and 180 nM, respectively. From the NCI anti-cancer screening results and the data from the in vitro toxicity screening on cultured AML cells, seven compounds: 8, 12, 21, 23, 25, 29 and 31 were screened for their in vitro inhibitory activity on tubulin polymerization in MV4-11 AML cells; at 50 nM, 8 and 29 inhibited polymerization of tubulin by >50%. The binding modes of the three most active compounds (8, 12 and 29) to tubulin were also investigated utilizing molecular docking studies. All three molecules were observed to bind in the same hydrophobic pocket at the interface of alpha- and beta-tubulin that is occupied by colchicine, and were stabilized by van der Waals' interactions with surrounding tubulin residues. The results from the tubulin polymerization and molecular docking studies indicate that compounds 8 and 29 are the most potent anti-leukemic compounds in this structural class, and are considered lead compounds for further development as anti-leukemic drugs. (C) 2015 Elsevier Masson SAS. All rights reserved.
• A novel and efficient tributyltin azide-mediated synthesis of 1H-tetrazolylstilbenes from cyanostilbenes
  作者：Narsimha Reddy Penthala、Shobanbabu Bommagani、Jaishankar Yadlapalli、Peter A. Crooks

  DOI：10.1016/j.tetlet.2016.03.040

  日期：2016.4

  A novel and efficient route was established for the synthesis of a series of (Z)-5-(2-(heteroaryl-2-yl) and (Z)-5-(3-(heteroaryl-3-yl)-1-(phenyl)vinyl)-1H-tetrazoles (3a–g and 6a–f, respectively) from cyanostilbene analogs containing benzo[b]thiophene, benzo[b]furan, and indole moieties utilizing tributyltin azide as a Lewis acid. This 1,3-dipolar [3+2]cycloaddition of azide to the cyano group of the

  建立了一种新颖且有效的路线来合成一系列（Z）-5-（2-（杂芳基-2-基）和（Z）-5-（3-（杂芳基-3-基）-1- （苯）乙烯基）-1 H-四唑（分别为3a - g和6a - f），它们来自氰基茂金属类似物，其中包含苯并[ b ]噻吩，苯并[ b ]呋喃和吲哚基团，使用三丁基叠氮化锡作为路易斯酸。叠氮化物的3，3-偶极[3 + 2]环加成到氰基茂金属前体分子的氰基上可提供相应四唑基茂金属类似物的良好产率，并且构成简单且成本有效的方法。