2,3,4-trimethoxybenzyl alcohol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,4-trimethoxybenzyl alcohol
• 英文别名: N-benzyl-2,3,4-trimethoxybenzamide
• 化学式: C₁₇H₁₉NO₄
• 分子量: 301.342
• InChiKey: ZKVJVCDQPQCYJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.235
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3,4-trimethoxybenzyl alcohol 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以70 %的产率得到N-benzyl-2,3,4-trihydroxybenzamide
  参考文献：
  名称：

  [EN] ESTROGENIC COMPOUNDS AND METHODS OF USE
  [FR] COMPOSÉS ŒSTROGÉNIQUES ET MÉTHODES D'UTILISATION

  摘要：

  Estrogenic compounds, compositions and method are presented. The novel estrogenic compounds comprise novel chalcone derivatives and analogs that have little or no measurable estrogen (estradiol, E2) activity but potentiate E2 activity without binding an estrogen receptor (ER). The novel compositions comprise one or more of the novel estrogenic compounds, and may optionally comprise one or more excipients. The one or more excipients may be pharmaceutically acceptable. The one or more excipients may comprise at least one compound that does not occur in nature with estrogenic compounds. The method comprises administering a pharmaceutical composition comprising an estrogenic compound described herein to a patient in need of treatment with an estrogenic compound or pharmaceutical composition.

  公开号：

  WO2024026034A1
• 作为产物：
  描述：

  2,3,4-三甲氧基苯甲醇 、 苄胺 在 C₅₃H₄₁ClN₄O₃P₂Ru 、 sodium hydride 、 乙腈 作用下， 以 甲苯 为溶剂， 反应 12.0h， 生成 2,3,4-trimethoxybenzyl alcohol
  参考文献：
  名称：

  含有二齿2-氧-1,2-二氢喹啉-3-甲醛醛ligand配体的钌（II）羰基配合物作为催化酰胺化反应的有效催化剂

  摘要：

  研究了钌（II）中2-氧-1,2-二氢喹啉-3-咔醛coordination配体的配位行为和新合成配合物的催化活性。络合物[RuCl（CO）（PPh 3）2（L 1）]（1），[RuCl（CO）（AsPh 3）2（L 1）]（2），[RuCl（CO）（PPh 3）2通过[RuHCl（CO）（EPh 3）3反应，合成了（L 2）]（3）和[RuCl（CO）（AsPh 3）2（L 2）]（4）。]（E = P或As）的前体，具有by配体，并通过分析和光谱学方法进行了表征。配合物2的分子结构通过单晶X射线衍射分析鉴定。结构分析表明，所有配合物均具有扭曲的八面体几何形状，配体以单负双齿NO方式配位。此外，在醇与胺直接酰胺化的情况下，已经研究了配合物的催化效率。还评估了碱，反应温度和催化剂用量在酰胺化反应中的影响。值得注意的是，复杂3据发现，它是将醇与胺酰胺化的非常有效的催化剂。具有各种官能团的多种芳族（杂）胺和醇也已成功地用于酰胺化。

  DOI：

  10.1016/j.jorganchem.2015.11.017

文献信息

• Ruthenium(II) carbonyl complexes containing bidentate 2-oxo-1,2-dihydroquinoline-3-carbaldehyde hydrazone ligands as efficient catalysts for catalytic amidation reaction
  作者：Sellappan Selvamurugan、Rangasamy Ramachandran、Govindan Prakash、Periasamy Viswanathamurthi、Jan Grzegorz Malecki、Akira Endo

  DOI：10.1016/j.jorganchem.2015.11.017

  日期：2016.2

  2-dihydroquinoline-3-carbaldehyde hydrazone ligands in ruthenium(II) and the catalytic activity of newly synthesized complexes have been studied. The complexes [RuCl(CO)(PPh3)2(L1)] (1), [RuCl(CO)(AsPh3)2(L1)] (2), [RuCl(CO)(PPh3)2(L2)] (3) and [RuCl(CO)(AsPh3)2(L2)] (4) were synthesized by reactions of [RuHCl(CO)(EPh3)3] (E = P or As) precursors with hydrazone ligands and characterized by analytical and spectroscopic

  研究了钌（II）中2-氧-1,2-二氢喹啉-3-咔醛coordination配体的配位行为和新合成配合物的催化活性。络合物[RuCl（CO）（PPh 3）2（L 1）]（1），[RuCl（CO）（AsPh 3）2（L 1）]（2），[RuCl（CO）（PPh 3）2通过[RuHCl（CO）（EPh 3）3反应，合成了（L 2）]（3）和[RuCl（CO）（AsPh 3）2（L 2）]（4）。]（E = P或As）的前体，具有by配体，并通过分析和光谱学方法进行了表征。配合物2的分子结构通过单晶X射线衍射分析鉴定。结构分析表明，所有配合物均具有扭曲的八面体几何形状，配体以单负双齿NO方式配位。此外，在醇与胺直接酰胺化的情况下，已经研究了配合物的催化效率。还评估了碱，反应温度和催化剂用量在酰胺化反应中的影响。值得注意的是，复杂3据发现，它是将醇与胺酰胺化的非常有效的催化剂。具有各种官能团的多种芳族（杂）胺和醇也已成功地用于酰胺化。
• Ruthenium(II) complexes encompassing 2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazone hybrid ligand: A new versatile potential catalyst for dehydrogenative amide synthesis
  作者：Sellappan Selvamurugan、Rangasamy Ramachandran、Govindan Prakash、Muthukumaran Nirmala、Periasamy Viswanathamurthi、Shoji Fujiwara、Akira Endo

  DOI：10.1016/j.ica.2015.12.024

  日期：2017.1

  Ruthenium(II) complexes (1-6) supported by a series of 2-oxo-1,2-dihydroquinoline-3-carbaldehyde substituted thiosemicarbazone ligands [2-oxo-1,2-dihydroquinoline-3-carbaldehyde thiosemicarbazone (L-1), 2-oxo-1,2-dihydroquinoline-3-carbaldehyde N-methyl thiosemicarbazone (L-2), 2-oxo-1,2-dihydroquinoline-3-carbaldehyde N-phenylthiosemicarbazone (L-3)] have been synthesized and structurally characterized by analytical, spectroscopic methods and X-ray crystallographic technique. The studies revealed that the ligands act as mononegative tridentate in ruthenium(II) complexes and a distorted octahedral geometry has been proposed for the complexes. In addition, the complexes have been found to catalyze the amidation of alcohols with amines in the presence of KtBuO-toluene system. The catalyst 3 displayed higher activity in substrates, including phenyl-, pyridine-, furan-, and thiophene-substituted alcohols with primary and secondary amines. The protocol is highly attractive because of easily available starting materials, high atom efficiency and environmental friendliness. (C) 2015 Elsevier B.V. All rights reserved.
• [EN] ESTROGENIC COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS ŒSTROGÉNIQUES ET MÉTHODES D'UTILISATION
  申请人：[en]IATERION, INC.

  公开号：WO2024026034A1

  公开（公告）日：2024-02-01

  Estrogenic compounds, compositions and method are presented. The novel estrogenic compounds comprise novel chalcone derivatives and analogs that have little or no measurable estrogen (estradiol, E2) activity but potentiate E2 activity without binding an estrogen receptor (ER). The novel compositions comprise one or more of the novel estrogenic compounds, and may optionally comprise one or more excipients. The one or more excipients may be pharmaceutically acceptable. The one or more excipients may comprise at least one compound that does not occur in nature with estrogenic compounds. The method comprises administering a pharmaceutical composition comprising an estrogenic compound described herein to a patient in need of treatment with an estrogenic compound or pharmaceutical composition.