2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-D-glucose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-D-glucose
• 英文别名: N-trichloroethoxycarbonyl-D-glucosamine；2,2,2-trichloroethyl N-[(2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]carbamate
• 化学式: C₉H₁₄Cl₃NO₇
• 分子量: 354.572
• InChiKey: GSQPWNTWUFOGQQ-BDVNFPICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  136
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  D-氨基葡萄糖盐酸盐 、 氯甲酸-2,2,2-三氯乙酯 在 碳酸氢钠 作用下， 以 水 为溶剂， 以297 g (90%)的产率得到2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-D-glucose
  参考文献：
  名称：

  Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor

  摘要：

  这项发明涉及生产烷基氨基葡糖氨磷酸化合物和二糖化合物的过程，包括各种新颖中间体和中间过程。在一个方面，通过将O-硅糖苷与二卤甲基烷醚反应来生产糖基卤化物。

  公开号：

  US20050107600A1

文献信息

• Process for preparing a disaccharide derivative
  申请人：Daiichi Pharmaceutical Co., Ltd.

  公开号：US05066794A1

  公开（公告）日：1991-11-19

  Disaccharide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 CO-- and R.sup.2 CO-- each represents a residue of a straight chain fatty acid having from 8 to 20 carbon atoms and having a hydroxyl group at the 3-position thereof; R.sup.3 CO-- and R.sup.4 CO-- each represents a residue of a straight chain fatty acid having from 8 to 20 carbon atoms; and m and n each represents an integer of from 8 to 12, and the salts thereof. The compounds exhibit biological activities equal to or higher than those of natural lipid A. Also, the compounds of this invention are very useful as standard reagent for determination of endotoxin in the samples to be tested.

  由公式(I)表示的二糖衍生物：其中R.sup.1 CO-和R.sup.2 CO-分别表示具有8至20个碳原子并在3位具有羟基的直链脂肪酸残基；R.sup.3 CO-和R.sup.4 CO-分别表示具有8至20个碳原子的直链脂肪酸残基；m和n分别表示从8到12的整数，以及它们的盐。这些化合物表现出与天然脂多糖A相等或更高的生物活性。此外，本发明的化合物在样品中检测内毒素时非常有用作标准试剂。
• Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors and intermediates therefor
  申请人：——

  公开号：US20040267007A1

  公开（公告）日：2004-12-30

  This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.

  本发明涉及生产烷基氨基葡萄糖胺磷酸化合物和二糖化合物的过程，包括各种新的中间体和中间体过程。在一个方面，通过将O-硅基糖苷与二卤甲基烷醚反应来生产糖基卤化物。
• PROCESSES FOR THE PRODUCTION OF AMINOALKYL GLUCOSAMINIDE PHOSPHATE AND DISACCHARIDE IMMUNOEFFECTORS, AND INTERMEDIATES THEREFOR
  申请人：Johnson A. David

  公开号：US20080033155A1

  公开（公告）日：2008-02-07

  This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.

  本发明涉及生产烷基氨基葡糖氨磷酸化合物和二糖化合物的过程，包括各种新的中间体和中间过程。在一个方面，通过将O-硅糖苷与二卤甲基烷醚反应来产生糖基卤化物。
• NOVEL GLUCOSE DERIVATIVE, AND CELL IMAGING METHOD AND IMAGING AGENT USING SAID DERIVATIVE
  申请人：Hirosaki University

  公开号：EP3130596A1

  公开（公告）日：2017-02-15

  A purpose of the present invention is to provide a novel glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Another purpose of the present invention is to provide an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Yet another purpose of the present invention is to provide a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. The present invention provides D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1) - (G4) below.

  本发明的一个目的是提供一种新型葡萄糖衍生物，它可通过膜糖转运系统被带入细胞，由式（1）表示。本发明的另一个目的是提供一种成像剂和一种使用所述葡萄糖衍生物的细胞或细胞内分子成像方法。本发明的另一个目的是提供一种使用所述葡萄糖衍生物准确检测癌细胞的方法和用于所述方法的成像剂。本发明提供了 D-葡萄糖衍生物和 L-葡萄糖衍生物，其中葡萄糖与具有香豆素骨架或醌骨架的荧光分子基团的 7 位结合。还提供了一种细胞成像剂和使用该衍生物的成像方法。还提供了一种癌细胞成像剂和使用 L-葡萄糖衍生物的成像方法。G 是选自以下式 (G1) - (G4) 的基团。
• Glucose derivative, and cell imaging method and imaging agent using said derivative
  申请人：HIROSAKI UNIVERSITY

  公开号：US10001487B2

  公开（公告）日：2018-06-19

  Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.

  本发明提供了一种葡萄糖衍生物，它可通过膜糖转运系统进入细胞，由式（1）表示。还提供了一种成像剂和一种使用所述葡萄糖衍生物对细胞或细胞内分子进行成像的方法。此外，还提供了一种使用所述葡萄糖衍生物精确检测癌细胞的方法和一种用于所述方法的成像剂。更具体地说，提供了 D-葡萄糖衍生物和 L-葡萄糖衍生物，其中葡萄糖与具有香豆素骨架或醌骨架的荧光分子基团的 7 位结合。还提供了一种细胞成像剂和使用该衍生物的成像方法。还提供了一种癌细胞成像剂和使用 L-葡萄糖衍生物的成像方法。G 是选自以下式 (G1)-(G4) 的基团。