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5-acetyl-2-hydroxy-3-methyl-benzoic acid

中文名称
——
中文别名
——
英文名称
5-acetyl-2-hydroxy-3-methyl-benzoic acid
英文别名
5-Acetyl-2-hydroxy-3-methyl-benzoesaeure;3-Methyl-5-acetyl-salicylsaeure;4-Oxy-5-methyl-acetophenon-carbonsaeure-(3);5-Acetyl-2-hydroxy-3-methylbenzoic acid
5-acetyl-2-hydroxy-3-methyl-benzoic acid化学式
CAS
——
化学式
C10H10O4
mdl
——
分子量
194.187
InChiKey
CGVBENFABSFCDS-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.4
  • 重原子数:
    14
  • 可旋转键数:
    2
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.2
  • 拓扑面积:
    74.6
  • 氢给体数:
    2
  • 氢受体数:
    4

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Benzoyl-piperazine derivatives
    申请人:Jolidon J. Synese
    公开号:US20050209241A1
    公开(公告)日:2005-09-22
    The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
    本发明涉及具有以下通式的化合物 其中取代基如本文所述。这些化合物可用于治疗基于抑制甘氨酸摄取的疾病,如精神疾病、疼痛、记忆和学习方面的神经退行性功能障碍、精神分裂症、痴呆症以及认知过程受损的其他疾病,例如注意力缺陷障碍或阿尔茨海默病。
  • [EN] DERIVATIVES OF THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES<br/>[FR] DERIVES D'INHIBITEURS DE THIAZOLE ET DE THIADIAZOLE DE TYROSINE PHOSPHATASES
    申请人:CENGENT THERAPEUTICS INC
    公开号:WO2006028970A1
    公开(公告)日:2006-03-16
    Provided herein are compounds and compositions for modulation of tyrosine phosphatase activity. In one embodiment, compounds and compositions for inhibiting protein tyrosine phosphatase activity are provided. In another embodiment, provided herein are compounds and compositions that are useful in the treatment, prevention, or amelioration of one or more symptoms of diseases caused by dysfunctional signal transduction, or in which dysfunctional signal transduction is implicated. In another embodiment, provided herein are compounds and compositions for treatment, prevention, or amelioration of one or more symptoms of diabetes. The compounds have following formulas: (II), (I), (III), and (IV).
    提供了一种用于调节酪氨酸磷酸酶活性的化合物和组合物。在一个实施例中,提供了用于抑制蛋白酪氨酸磷酸酶活性的化合物和组合物。在另一个实施例中,提供了用于治疗、预防或改善由信号转导功能障碍引起的一种或多种症状的疾病,或其中信号转导功能障碍涉及的疾病。在另一个实施例中,提供了用于治疗、预防或改善糖尿病的一种或多种症状的化合物和组合物。这些化合物的公式如下:(II),(I),(III)和(IV)。
  • [EN] PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND THEIR USE AS GLYT1 INHIBITORS<br/>[FR] PIPERAZINE AVEC GROUPE PHENYLE SUBSTITUE DE TYPE OR ET LEUR UTILISATION COMME INHIBITEURS DE GLYT1
    申请人:HOFFMANN LA ROCHE
    公开号:WO2005014563A1
    公开(公告)日:2005-02-17
    The invention relates to compounds of formula (I) wherein the substituents are described in claim 1. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.
    该发明涉及式(I)化合物,其中取代基如权利要求书中所述。这些化合物可用于治疗基于甘氨酸摄取抑制剂的疾病,如精神病、疼痛、记忆和学习中的神经退行性功能障碍、精神分裂症、痴呆症以及其他认知过程受损的疾病,如注意力缺陷障碍或阿尔茨海默病。
  • Allosteric inhibitors of pyruvate kinase
    申请人:——
    公开号:US20010046997A1
    公开(公告)日:2001-11-29
    Chemical structures have been identified which allosterically modify pyrvate kinase and inhibit enzymatic activity. These compounds can be used as pharmaceuticals in the treatment of a wide variety of diseases and disorders where influencing metabolic processes is beneficial, such as the glycolytic pathway, all pathways which use ATP as an energy source, and all pathways which involve 2,3-diphosphoglycerate related to the delivery of oxygen by modifying hemoglobin's oxygen affinity, treatments of tumor and cancer and Alzheimer's disease (AD).
    已经鉴定出一些化学结构,可以使变构酶发生变异并抑制其酶活性。这些化合物可用作药物,用于治疗各种疾病和障碍,其中影响代谢过程有益的疾病,例如糖酵解途径,所有使用ATP作为能源的途径,以及所有涉及2,3-二磷酸甘油酸与通过修改血红蛋白的氧亲和力来传递氧的途径,肿瘤和癌症以及阿尔茨海默病(AD)的治疗。
  • Thiazole and thiadiazole inhibitors of tyrosine phosphatases
    申请人:Cheruvallath S. Zacharia
    公开号:US20060194768A1
    公开(公告)日:2006-08-31
    Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.
    本发明提供了用于调节蛋白酪氨酸磷酸酶活性的化合物和组合物。在一种实施方式中,所述化合物和组合物是噻唑和噻二唑,可抑制蛋白酪氨酸磷酸酶1B的活性。
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