4,6-dimethoxy-2-(1H-imidazol-1-yl)pyrimidine

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,6-dimethoxy-2-(1H-imidazol-1-yl)pyrimidine
• 英文别名: 1-(4,6-dimethoxypyrimidin-2-yl)-imidazole；2-Imidazol-1-yl-4,6-dimethoxypyrimidine
• 化学式: C₉H₁₀N₄O₂
• 分子量: 206.204
• InChiKey: GDWNDIGXNLYLAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  62.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  咪唑 、 2-氯-4,6-二甲氧基嘧啶 在 三乙胺 作用下， 以 异丙醇 为溶剂， 反应 12.0h， 以75%的产率得到4,6-dimethoxy-2-(1H-imidazol-1-yl)pyrimidine
  参考文献：
  名称：

  Using N-substituted-2-amino-4,6-dimethoxypyrimidines in the synthesis of aliphatic guanidines

  摘要：

  The use of 2-chloro-4,6-dimethoxypyrimdine as a tool for the syntheses of substituted guanidines is presented. This method, that we had previously shown to be very useful for aromatic amines, introduces an atom economical, cost effective and environmentally functionality in aliphatic primary and secondary amin safe method for the installation of the guanidine (C) 2015 Elsevier Ltd. All rights reserved.d

  DOI：

  10.1016/j.tetlet.2015.07.007

文献信息

• Chloropyridylcarbonyl derivatives and their use as microbiocides
  申请人：NIHON BAYER AGROCHEM K.K.

  公开号：EP0763530A1

  公开（公告）日：1997-03-19

  Novel chloropyridylcarbonyl derivatives of the formula in which Hetis nis 1 or 2, R1is hydrogen, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C3-6 alkynyl, optionally substituted phenyl or optionally substituted pyrimidinyl, and R2 and R3,independently of each other, are hydrogen or C1-4 alkyl, and acid addition salts and metal salt complexes thereof, processes for the preparation of the new compounds and their use as microbicides.

  式中的新型氯吡啶羰基衍生物 其中 Hetis 为 1 或 2、 R1 是氢、任选取代的 C1-6 烷基、任选取代的 C2-6 烯基、任选取代的 C3-6 烷炔基、任选取代的苯基或任选取代的嘧啶基，以及 R2 和 R3 相互独立地为氢或 C1-4 烷基、 及其酸加成盐和金属盐络合物、 新化合物的制备工艺及其作为杀微生物剂的用途。
• US5849767A
  申请人：——

  公开号：US5849767A

  公开（公告）日：1998-12-15
• Using N-substituted-2-amino-4,6-dimethoxypyrimidines in the synthesis of aliphatic guanidines
  作者：Julian W. Shaw、Laure Barbance、David H. Grayson、Isabel Rozas

  DOI：10.1016/j.tetlet.2015.07.007

  日期：2015.8

  The use of 2-chloro-4,6-dimethoxypyrimdine as a tool for the syntheses of substituted guanidines is presented. This method, that we had previously shown to be very useful for aromatic amines, introduces an atom economical, cost effective and environmentally functionality in aliphatic primary and secondary amin safe method for the installation of the guanidine (C) 2015 Elsevier Ltd. All rights reserved.d