3-(4-nitro-phenylsulfanyl)-1,3-diphenyl-propan-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(4-nitro-phenylsulfanyl)-1,3-diphenyl-propan-1-one
• 英文别名: 3-(4-nitrophenylsulfanyl)-1,3-diphenylpropan-1-one；3-(4-Nitrophenyl)sulfanyl-1,3-diphenylpropan-1-one
• 化学式: C₂₁H₁₇NO₃S
• 分子量: 363.437
• InChiKey: MNEXHRFTJIQXRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  88.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯甲醛 在 氯化锆(IV) 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 3-(4-nitro-phenylsulfanyl)-1,3-diphenyl-propan-1-one
  参考文献：
  名称：

  Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents

  摘要：

  A new series of 1,3-biarylsulfanyl derivatives (homodibenzyl core motif) have been designed and synthesized as new estrogen receptor ligands by chopping benzothiophene core of raloxifene to engender secoraloxifene scaffold. All the synthesized compounds were screened for anti-proliferative, anti-osteoporotic, and anti-implantation activity. Compounds (35, 36) having basic amino anti-estrogenic side chain were exhibiting potential anti-proliferative activity in MCF-7, MDA-MB-231 and ishikawa cell lines. Some of the synthesized compounds having homodibenzyl motif (5, 8, 10) have shown moderate anti-osteoporotic activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.07.056

文献信息

• Fluoroboric acid adsorbed on silica-gel (HBF4–SiO2) as a new, highly efficient and reusable heterogeneous catalyst for thia-Michael addition to α,β-unsaturated carbonyl compounds
  作者：Gaurav Sharma、Raj Kumar、Asit K. Chakraborti

  DOI：10.1016/j.tetlet.2008.04.144

  日期：2008.6

  found to be a new and highly efficient heterogeneous catalyst for thia-Michael addition to α,β-unsaturated carbonyl compounds under solvent-free conditions. In the case of 1,3-diaryl-2-propenones, the reactions are best carried out in MeOH. The rate of thia-Michael addition was dependent on the steric hindrance at the β-carbon of the α,β-unsaturated carbonyl substrate as well as surrounding the thiol

  已经发现，吸附在硅胶上的氟硼酸（HBF 4 -SiO 2）是一种新型的高效多相催化剂，可在无溶剂条件下将硫杂-迈克尔加成到α，β-不饱和羰基化合物上。在1,3-二芳基-2-丙烯酮的情况下，反应最好在MeOH中进行。thia-Michael加成的速率取决于α，β-不饱和羰基底物的β-碳以及周围硫醇部分的位阻，并被用于在两个烯酮之间的分子间竞争中选择性的thia-Michael加成。常见的硫醇和两个芳基/烷基硫醇之间的一个常见的烯酮 该方法可用于一锅合成2,3-二氢-1,5-苯并噻氮ze类化合物。
• Scope and limitations of HClO4–SiO2 as an extremely efficient, inexpensive, and reusable catalyst for chemoselective carbon–sulfur bond formation
  作者：Gopal L. Khatik、Gaurav Sharma、Raj Kumar、Asit K. Chakraborti

  DOI：10.1016/j.tet.2006.11.050

  日期：2007.1

  cyclic and acyclic α,β-unsaturated ketones afforded excellent yields of the corresponding β-sulfidocarbonyls after 2 min to 2 h. In the case of dithiols, the bis-thia-Michael adducts were formed. The rate of the reaction was found to be dependent on the electronic and steric factors of the α,β-unsaturated ketones and the thiols. A substituent at the β-carbon of the α,β-unsaturated ketone offered steric

  高氯酸吸附在硅胶上的范围和限制（HClO 4 -SiO 2）是一种高效，廉价且可重复使用的催化剂，可通过在无溶剂条件下和室温下将硫醇共轭添加到α，β-不饱和酮上来形成化学选择性碳-硫键。对于1,3-二苯基丙烯酮，反应最好在无溶剂条件下于80°C或在室温下于MeOH中进行。芳基，芳基烷基，烷基硫醇和烷烃二硫醇与环状和无环α，β-不饱和酮反应后，在2分钟至2小时后，其相应的β-硫代羰基羰基化合物的收率极高。在二硫醇的情况下，形成了二硫杂-迈克尔加合物。发现反应速率取决于α，β-不饱和酮和硫醇的电子和空间因素。α的β-碳原子上的取代基，β-不饱和酮为共轭物的添加提供了空间位阻，此类底物需要更长的时间。在芳族硫醇的情况下，硝基的存在降低了巯基硫原子的亲核性，导致4-硝基硫代苯酚的反应速率低于硫代苯酚和4-甲基硫代苯酚的反应速率。对于烷硫醇，反应速率受连接至巯基部分的烷基的空间拥挤影响。与芳基硫醇相