r-1,c-3-diphenyl-t-2-benzoyl-5-hydroxy-6-methoxyindane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: r-1,c-3-diphenyl-t-2-benzoyl-5-hydroxy-6-methoxyindane
• 英文别名: [(1R,2R,3S)-5-hydroxy-6-methoxy-1,3-diphenyl-2,3-dihydro-1H-inden-2-yl]-phenylmethanone
• 化学式: C₂₉H₂₄O₃
• 分子量: 420.508
• InChiKey: KKUONQJCALLZMU-UPRLRBBYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-(hydroxy(phenyl)methyl)-2-methoxyphenol 、 苯亚甲基苯乙酮 在 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以31%的产率得到r-1,c-3-diphenyl-t-2-benzoyl-5-hydroxy-6-methoxyindane
  参考文献：
  名称：

  Scope of the formal [3+2] cycloaddition for the synthesis of five-membered ring of functionalized indanes

  摘要：

  We report our research about the synthesis of functionalized indanes in the pentagonal ring by a formal [3+2] cycloaddition using benzhydrols and styrene derivatives with electron-withdrawing groups joined to C-beta, such as carboxyl, carboxymethyl, carbonyl of ketones, and nitro groups. We also report the configurational assignment of the indanic structures synthesized using several experiments of NMR. (C) 2011 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2011.10.089

文献信息

• Scope of the formal [3+2] cycloaddition for the synthesis of five-membered ring of functionalized indanes
  作者：Beatriz Lantaño、Jose Manuel Aguirre、Esteban Ariel Ugliarolo、Rosario Torviso、Nicolás Pomilio、Graciela Yolanda Moltrasio

  DOI：10.1016/j.tet.2011.10.089

  日期：2012.1

  We report our research about the synthesis of functionalized indanes in the pentagonal ring by a formal [3+2] cycloaddition using benzhydrols and styrene derivatives with electron-withdrawing groups joined to C-beta, such as carboxyl, carboxymethyl, carbonyl of ketones, and nitro groups. We also report the configurational assignment of the indanic structures synthesized using several experiments of NMR. (C) 2011 Published by Elsevier Ltd.