N-methyl-2-phenylquinolin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-methyl-2-phenylquinolin-4-amine
• 英文别名: methyl-(2-phenyl-[4]quinolyl)-amine；Methyl-(2-phenyl-[4]chinolyl)-amin
• 化学式: C₁₆H₁₄N₂
• mdl: MFCD17945000
• 分子量: 234.301
• InChiKey: GHWMIPNPRROXQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.062
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(2-phenyl-[4]quinolyl)-glycine 生成 N-methyl-2-phenylquinolin-4-amine
  参考文献：
  名称：

  John; Behmel, Journal fuer Praktische Chemie (Leipzig), 1932, vol. <2> 135, p. 215,220

  摘要：

  DOI：

文献信息

• Investigation of amination in 4-chloro-2-phenylquinoline derivatives with amide solvents
  作者：Jui-Ying Tsai、Chih-Shiang Chang、Yi-Fan Huang、Hua-Shin Chen、Shao-Kai Lin、Fung Fuh Wong、Li-Jiau Huang、Sheng-Chu Kuo

  DOI：10.1016/j.tet.2008.09.100

  日期：2008.12

  Novel 4-amino-2-phenylquinoline derivatives were synthesized by reacting various 4-chloro-2-aryl-quinoline compounds having activated chloro group with the corresponding imide solvents at reflux for overnight. The activity of amination by the amide solvents depended on the competition between the steric and electronic effect of the N-substituents on the amino group. Their activities were shown as N,N-dimethylformamide>N,N-diethylformamide>N-methylformamide>formamide>N,N-dimethylacetamide> N,N-dimethylpropionamide. The yields for the amination products seemed proportional to the ease of the dissociation of the amides. (C) 2008 Published by Elsevier Ltd.
• John; Behmel, Journal fuer Praktische Chemie (Leipzig), 1932, vol. <2> 135, p. 215,220
  作者：John、Behmel

  DOI：——

  日期：——