N-(2-methoxyethyl)-4-acetylaniline

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(2-methoxyethyl)-4-acetylaniline
• 英文别名: 1-[4-(2-Methoxyethylamino)phenyl]ethanone
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: KSPVDKMYNTVXFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-溴苯乙酮 、 2-甲氧基乙胺 在 potassium phosphate 、 copper(l) iodide 、 N,N-二乙基水杨酰胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 以77%的产率得到N-(2-methoxyethyl)-4-acetylaniline
  参考文献：
  名称：

  Mild and Efficient Copper-Catalyzed Amination of Aryl Bromides with Primary Alkylamines

  摘要：

  GraphicsAn efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 degreesC in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.

  DOI：

  10.1021/ol0273396

文献信息

• Mild and Efficient Copper-Catalyzed Amination of Aryl Bromides with Primary Alkylamines
  作者：Fuk Yee Kwong、Stephen L. Buchwald

  DOI：10.1021/ol0273396

  日期：2003.3.1

  GraphicsAn efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 degreesC in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.