methyl 2-cyclopropyloxirane-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 环氧化物
• 英文名称: methyl 2-cyclopropyloxirane-2-carboxylate
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: XCXPMOVYRNEEAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 2-cyclopropyloxirane-2-carboxylate 在 sodium hydroxide 、 硫酸羟胺 作用下， 以 水 为溶剂， 反应 2.0h， 以57%的产率得到(Z)-2-cyclopropylacetaldehyde oxime
  参考文献：
  名称：

  [EN] BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF
  [FR] COMPOSÉS CÉTONIQUES BICYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  这项发明提供了具有通式（I）的新化合物：（I）其中R1，A环和B环如本文所述，包括这些化合物的药物组合物，以及使用这些化合物的方法。

  公开号：

  WO2019012063A1
• 作为产物：
  描述：

  氯乙酸甲酯 、 环丙甲醛 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 18.0h， 以53%的产率得到methyl 2-cyclopropyloxirane-2-carboxylate
  参考文献：
  名称：

  [EN] BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF
  [FR] COMPOSÉS CÉTONIQUES BICYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION

  摘要：

  这项发明提供了具有通式（I）的新化合物：（I）其中R1，A环和B环如本文所述，包括这些化合物的药物组合物，以及使用这些化合物的方法。

  公开号：

  WO2019012063A1

文献信息

• Filled thermoplastic compositions based on ethylene interpolymers and polyester, polyether and polyether ester plasticizers
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0045968A2

  公开（公告）日：1982-02-17

  Filled thermoplastic compositions useful, e.g., as sound-deadening sheeting for automotive carpet are obtained by blending about 5-55% by weight of an ethylene interpolymer, such as ethylene/vinyl ester, ethylene/unsaturated mono- or dicarboxylic acids or esters of said unsaturated acids, etc.; about 1-15% by weight of a plasticizer selected from the group consisting of polyesters, polyethers, polyether esters and combinations thereof with processing oil; about 40-90% by weight of filler; and optionally modifying resins, such as unvulcanized elastomeric polymers and certain other ethylene and propylene homo- and copolymers.

  填充热塑性塑料组合物可用作汽车地毯的消音片材、作为汽车地毯消音片材的填充热塑性塑料混合物，可通过混合约 5-55% （按重量计）的乙烯间聚合物，如乙烯/乙烯酯、乙烯/不饱和单羧酸或二羧酸或上述不饱和酸的酯类等；约 1-15% （按重量计）的增塑剂，这些增塑剂选自聚酯、聚醚、聚醚酯和增塑剂的组合。约 1-15%（按重量计）的增塑剂，增塑剂选自聚酯、聚醚、聚醚酯及其与加工油的组合；约 40-90%（按重量计）的填料；以及可选的改性树脂，如未硫化弹性聚合物和某些其他乙烯和丙烯均聚物和共聚物。
• Wood-like articles made from cellulosic filler loaded ethylene interpolymers
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0114409A1

  公开（公告）日：1984-08-01

  Articles having wood-like properties and appearance are obtained from compositions comprising 5-55% by weight of an ethylene interpolymer, such as ethylenelvinyl ester, ethylene/unsaturated mono- or dicarboxylic acids or esters or salts of said unsaturated acids, etc.; 1-15% by weight of at least one plasticizer selected from the group consisting of processing oils, expoxidized oils, polyesters, polyethers and polyetheresters; 20-90% by weight of cellulosic filler or mixture of cellulosic filler and mineral filler; 0-10% by weight of at least one additive, such as organic acid, organic acid derivative and surface active agent; and 0-44% by weight of certain ethylene and propylene homo- and copolymers.

  具有类似木材的特性和外观的物品可由以下成分制成：5-55%（重量）的乙烯间聚合 物，如乙烯乙烯酯、乙烯/不饱和单羧酸或二羧酸或上述不饱和酸的酯或盐等；1-15% （重量）的至少一种增塑剂，该增塑剂选自加工油、过氧化油、聚酯和聚醚酯； 20-90%（重量）的纤维素，该纤维素选自加工油、过氧化油、聚酯和聚醚酯。至少一种增塑剂，选自加工油、过氧化油、聚酯、聚醚和聚醚酯组成的组；纤维素填料或纤维素填料和矿物填料混合物的重量百分比为 20-90%；至少一种添加剂，如有机酸、有机酸衍生物和表面活性剂的重量百分比为 0-10%；以及某些乙烯和丙烯均聚物和共聚物的重量百分比为 0-44%。
• Curable polymeric compositions
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0118312A2

  公开（公告）日：1984-09-12

  Polymers having 1,4-diketo functionalities and a carbonyl group concentration of at least 5% of polymer weight can be conveniently cured by heating with a primary diamine or its precursor and a catalytic amount of an acid having a pKa of at most about 3. Cured polymers have good physical properties and are suitable in such applications as, for example hose, tubing, wire coatings, gaskets, and seals.

  具有 1,4-二酮官能团且羰基浓度至少为聚合物重量的 5%的聚合物，可通过与伯二胺或其前体以及催化量的 pKa 至多为 3 左右的酸一起加热固化。
• Extrudable self-supporting hot melt adhesive sheet
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0101028A1

  公开（公告）日：1984-02-22

  Extrudable, self-supporting, nonblocking hot melt adhesive sheet is obtained by blending about 10-50% by weight of an ethylene interpolymer, such as ethylene/vinyl ester, ethylene/unsaturated mono- or dicarboxylic acids or esters of said unsaturated acids, erc.; 2-30% by weight of a plasticizer selected from the group consisting of processing oils, epoxidized oils, polyesters, polyethers, polyether esters and combinations thereof; about 20-80% by weight of filler; from 0 to about 10% by weight of at least one additive, such as organic acids, organic acid derivatives and surface active agents..

  2-30%（按重量计）的增塑剂，该增塑剂选自加工油、环氧化油、聚酯、聚醚、聚醚酯及其组合；约 20-80%（按重量计）的填料；0-约 10%（按重量计）的至少一种添加剂，如有机酸、有机酸衍生物和表面活性剂。
• Leather-like articles made from cellulosic filler loaded ethylene interpolymers
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0113916A1

  公开（公告）日：1984-07-25

  Articles having leather-like appearance are obtained from compositions comprising 15-55% by weight of an ethylene interpolymer such as ethylene/vinyl ester, ethylene/unsaturated mono- or dicarboxylic acids or esters of said unsaturated acids. ethylene/a-olefin copolymers, etc.; 1-15% by weight of at least one plasticizer selected from the group consisting of processing oils, epoxidized oils, polyesters, polyethers and polyetheresters; 20-70% by weight of cellulosic filler or mixture of cellulosic filler and mineral filler; 0-10% by weight of at least one additive, such as organic acid organic acid derivative and surface active agent: and 0-27.5% by weight of elastomeric polymer.

  具有皮革般外观的物品可由以下成分制成：15-55%（按重量计）的乙烯间聚合物，如乙烯/乙烯酯、乙烯/不饱和单羧酸或二羧酸或上述不饱和酸的酯类、乙烯/a-烯烃共聚物等；1-15%（按重量计）的增塑剂，该增塑剂选自加工油、环氧化油、聚酯、聚醚醚酮组成的组。至少一种增塑剂，选自加工油、环氧化油、聚酯、聚醚醚酮组成的组；纤维素填料或纤维素填料与矿物填料的混合物，重量百分比为 20-70%；至少一种添加剂，如有机酸、有机酸衍生物和表面活性剂，重量百分比为 0-10%；以及弹性聚合物，重量百分比为 0-27.5%。