1-(1-benzyl-4-(((4R,5R)-5-heptyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-1H-1,2,3-triazol-5-yl)propan-1-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(1-benzyl-4-(((4R,5R)-5-heptyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-1H-1,2,3-triazol-5-yl)propan-1-ol
• 英文别名: 1-[3-benzyl-5-[[(4R,5R)-5-heptyl-2,2-dimethyl-1,3-dioxolan-4-yl]methyl]triazol-4-yl]propan-1-ol
• 化学式: C₂₅H₃₉N₃O₃
• 分子量: 429.603
• InChiKey: NWELPAWNGJZIBY-XMCWYHTOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-benzyl-4-(((4R,5R)-5-heptyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-1H-1,2,3-triazole 、 丙醛 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 以54%的产率得到1-(1-benzyl-4-(((4R,5R)-5-heptyl-2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-1H-1,2,3-triazol-5-yl)propan-1-ol
  参考文献：
  名称：

  JP5822991

  摘要：

  公开号：

文献信息

• COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING TOXICITY AND TREATING OR PREVENTING DISEASES
  申请人：Danishefsky Samuel J.

  公开号：US20110312904A1

  公开（公告）日：2011-12-22

  The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).

  本发明提供了公式(I)的化合物，以及包含公式(I)化合物的有效量的组合物，可选地与化疗药物如微管结合药物一起使用，并用于减少细胞毒性药物的毒性，治疗或预防癌症或神经病理性障碍，诱导化学保护性II期酶、DNA或蛋白质合成，增强免疫系统，治疗炎症，改善和增强整体健康或福祉，以及制备公式(I)化合物的方法。
• Compounds, compositions and methods for reducing toxicity and treating or preventing diseases
  申请人：Danishefsky Samuel J.

  公开号：US08859615B2

  公开（公告）日：2014-10-14

  The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).

  本发明提供公式（I）化合物，包括含有公式（I）化合物的有效量的组合物，可选地与化疗药物如微管结合药物一起使用，并用于降低细胞毒性药剂的毒性，治疗或预防癌症或神经病理性疾病，诱导化学保护期II酶、DNA或蛋白质的合成，增强免疫系统，治疗炎症，改善和增强一般健康或福祉，并提供公式（I）化合物的制备方法。
• US8859615B2
  申请人：——

  公开号：US8859615B2

  公开（公告）日：2014-10-14
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING TOXICITY AND TREATING OR PREVENTING DISEASES<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS POUR RÉDUIRE LA TOXICITÉ ET POUR TRAITER OU PRÉVENIR DES MALADIES
  申请人：UNIV COLUMBIA

  公开号：WO2010025272A1

  公开（公告）日：2010-03-04

  The present invention provides compounds of Formula (I), compositions comprising an effective amount of a Compound of Formula (I), optionally with chemotherapeutic drug, such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, for example chemotherapy agents, treating or preventing cancer or a neurotrophic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making Compounds of Formula (I).
• JP5822991
  申请人：——

  公开号：——

  公开（公告）日：——