4-(6-carboxyhexyl)-2,2-dimethyl-5-oxo-1,3-dioxolane

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(6-carboxyhexyl)-2,2-dimethyl-5-oxo-1,3-dioxolane
• 英文别名: 7-(2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl)heptanoic acid
• 化学式: C₁₂H₂₀O₅
• 分子量: 244.288
• InChiKey: XSDNVMLGVQAFTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  呋喃 、 4-(6-carboxyhexyl)-2,2-dimethyl-5-oxo-1,3-dioxolane 在 盐酸 、 三氟乙酸酐 作用下， 以 二氯甲烷 、 水 、 丙酮 为溶剂， 生成 8-(2-furoyl)-2-hydroxyoctanoic acid
  参考文献：
  名称：

  1-Hydroxymethyl-prosten-1-ol derivatives

  摘要：

  抗前列腺素类似物被披露，其α-链以基团--CH(OR')OR"终止，其中R'和R"相同或不同，可以是氢、C.sub.1到C.sub.4烷酰基或可选择的取代苯甲酰基，取代基选自C.sub.1到C.sub.4烷基、C.sub.1到C.sub.4烷氧基、卤素和三氟甲基。这些化合物可用作降压剂、胃分泌抑制剂、血小板聚集抑制剂和支气管扩张剂。

  公开号：

  US04289910A1
• 作为产物：
  描述：

  2-hydroxynonanedioic acid 在 硫酸 、 sodium carbonate 作用下， 以 丙酮 、 Petroleum ether 为溶剂， 生成 4-(6-carboxyhexyl)-2,2-dimethyl-5-oxo-1,3-dioxolane
  参考文献：
  名称：

  1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives

  摘要：

  抗前列腺素类似物被披露，其α-链以基团--CH(OR')OR"终止，其中R'和R"相同或不同，可以是氢、C.sub.1到C.sub.4的烷酰基或可选择的取代苯甲酰基，取代基选择自C.sub.1到C.sub.4的烷基、C.sub.1到C.sub.4的烷氧基、卤素和三氟甲基。这些化合物可用作降压剂、胃分泌和血小板聚集抑制剂以及支气管扩张剂。

  公开号：

  US04291175A1

文献信息

• 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives
  申请人：American Cyanamid Company

  公开号：US04291175A1

  公开（公告）日：1981-09-22

  Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

  抗前列腺素类似物被披露，其α-链以基团--CH(OR')OR"终止，其中R'和R"相同或不同，可以是氢、C.sub.1到C.sub.4的烷酰基或可选择的取代苯甲酰基，取代基选择自C.sub.1到C.sub.4的烷基、C.sub.1到C.sub.4的烷氧基、卤素和三氟甲基。这些化合物可用作降压剂、胃分泌和血小板聚集抑制剂以及支气管扩张剂。
• 1-Hydroxymethyl-11,16-dihydroxy-prosten-1-ol derivatives
  申请人：American Cyanamid Company

  公开号：US04288632A1

  公开（公告）日：1981-09-08

  Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

  抗前列腺素类似物被披露，其α-链以基团--CH(OR')OR"终止，其中R'和R"相同或不同，可以是氢、C.sub.1到C.sub.4烷酰基或可选择的取代苯甲酰基，取代基选自C.sub.1到C.sub.4烷基、C.sub.1到C.sub.4烷氧基、卤素和三氟甲基。这些化合物可用作降压剂、胃分泌抑制剂、血小板聚集抑制剂和支气管扩张剂。
• 1-Hydroxymethyl-11,15-dihydroxy-prosten-1-ol-derivatives
  申请人：American Cyanamid Company

  公开号：US04288630A1

  公开（公告）日：1981-09-08

  Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

  抗前列腺素类似物被披露，其α-链以--CH(OR')OR"基团终止，其中R'和R"相同或不同，是氢，C.sub.1到C.sub.4烷酰基或可选择的取代苯甲酰基，取代基选自C.sub.1到C.sub.4烷基，C.sub.1到C.sub.4烷氧基，卤素和三氟甲基。这些化合物可用作降压剂、胃分泌抑制剂、血小板聚集抑制剂和支气管扩张剂。
• 1-Hydroxymethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives
  申请人：American Cyanamid Company

  公开号：US04288633A1

  公开（公告）日：1981-09-08

  Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

  抗前列腺素类似物被披露，其α-链以基团--CH(OR')OR"终止，其中R'和R"相同或不同，可为氢、C.sub.1至C.sub.4烷酰基或可选择的苯甲酰基，取代基选自C.sub.1至C.sub.4烷基、C.sub.1至C.sub.4烷氧基、卤素和三氟甲基。这些化合物可用作降压剂、胃分泌抑制剂、血小板聚集抑制剂和支气管扩张剂。
• 1-Hydroxymethyl-prosten-1-ol derivatives
  申请人：American Cyanamid Company

  公开号：US04289910A1

  公开（公告）日：1981-09-15

  Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

  抗前列腺素类似物被披露，其α-链以基团--CH(OR')OR"终止，其中R'和R"相同或不同，可以是氢、C.sub.1到C.sub.4烷酰基或可选择的取代苯甲酰基，取代基选自C.sub.1到C.sub.4烷基、C.sub.1到C.sub.4烷氧基、卤素和三氟甲基。这些化合物可用作降压剂、胃分泌抑制剂、血小板聚集抑制剂和支气管扩张剂。