10-(2-chlorophenyl)-7,8-dihydro-7,7-dimethyl-5-(4-methylphenyl)-5H-indeno[1,2-b]quinolin-9,11(6H,10H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-(2-chlorophenyl)-7,8-dihydro-7,7-dimethyl-5-(4-methylphenyl)-5H-indeno[1,2-b]quinolin-9,11(6H,10H)-dione
• 英文别名: 5-(2-chlorophenyl)-7,8-dihydro-7,7-dimethyl-10-(4-methylphenyl)-5H-indeno[1,2-b]quinolin-9,11(6H,10H)-dione；10-(2-chlorophenyl)-7,7-dimethyl-5-(4-methylphenyl)-8,10-dihydro-6H-indeno[1,2-b]quinoline-9,11-dione
• 化学式: C₃₁H₂₆ClNO₂
• 分子量: 480.006
• InChiKey: MASQSBHSPZIHSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  35
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,3-茚满二酮 、 5,5-二甲基-3-(4-甲基苯胺基)环己-2-烯-1-酮 、 2-氯苯甲醛 在 1-butyl-3-methylimidazolium Tetrafluoroborate 作用下， 反应 5.0h， 以96%的产率得到10-(2-chlorophenyl)-7,8-dihydro-7,7-dimethyl-5-(4-methylphenyl)-5H-indeno[1,2-b]quinolin-9,11(6H,10H)-dione
  参考文献：
  名称：

  Three-component green synthesis of N-arylquinoline derivatives in ionic liquid [Bmim+][BF4−]: reactions of arylaldehyde, 3-arylamino-5,5-dimethylcyclohex-2-enone, and active methylene compounds

  摘要：

  Three series of N-arylquinoline derivatives were synthesized by the three-component reactions of arylaidehyde, 3-arylamino-5,5-diinethyleyclohex-2-enone, and active methylene compounds including malononitrile, meldrum's acid, and 1,3-indenedione in ionic liquid [bmim(+)][BF4-] at 90 degrees C. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.03.068

文献信息

• Simple route to indeno[1,2-b]quinoline derivatives via a coupling reaction catalyzed by TiO2 nanoparticles
  作者：Shahrzad Abdolmohammadi

  DOI：10.1016/j.cclet.2013.02.017

  日期：2013.4

  A simple, efficient and high yielding approach for the synthesis of indeno[1,2-b]quinolinediones has been developed by a one-pot, four-component, coupling reaction utilizing TiO2 nanoparticles (TiO2-NPs) as a heterogeneous catalyst at 80 degrees C in aqueous media. (C) 2013 Shahrzad Abdolmohammadi. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
• Three-component green synthesis of N-arylquinoline derivatives in ionic liquid [Bmim+][BF4−]: reactions of arylaldehyde, 3-arylamino-5,5-dimethylcyclohex-2-enone, and active methylene compounds
  作者：Xiang-Shan Wang、Mei-Mei Zhang、Hong Jiang、Chang-Sheng Yao、Shu-Jiang Tu

  DOI：10.1016/j.tet.2007.03.068

  日期：2007.5

  Three series of N-arylquinoline derivatives were synthesized by the three-component reactions of arylaidehyde, 3-arylamino-5,5-diinethyleyclohex-2-enone, and active methylene compounds including malononitrile, meldrum's acid, and 1,3-indenedione in ionic liquid [bmim(+)][BF4-] at 90 degrees C. (C) 2007 Elsevier Ltd. All rights reserved.
• Wang, Xiang-Shan; Zhang, Mei-Mei; Zeng, Zhao-Sen, Journal of Heterocyclic Chemistry, 2008, vol. 45, # 1, p. 71 - 76
  作者：Wang, Xiang-Shan、Zhang, Mei-Mei、Zeng, Zhao-Sen、Shi, Da-Qing、Tu, Shu-Jiang、Wei, Xian-Yong、Zong, Zhi-Min

  DOI：——

  日期：——