1-(4-chlorobenzyloxy)-2-methyl-4-chlorobenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(4-chlorobenzyloxy)-2-methyl-4-chlorobenzene
• 英文别名: 4-Chloro-1-[(4-chlorophenyl)methoxy]-2-methylbenzene；4-chloro-1-[(4-chlorophenyl)methoxy]-2-methylbenzene
• 化学式: C₁₄H₁₂Cl₂O
• 分子量: 267.155
• InChiKey: QZEUIIPTBVZHOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基-1-苄氧基苯 在 磺酰氯 、 potassium carbonate 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 0.84h， 生成 1-(4-chlorobenzyloxy)-2-methyl-4-chlorobenzene
  参考文献：
  名称：

  On the para-selective chlorination of ortho-cresol

  摘要：

  Merrifield-bound o-cresol undergoes electrophilic aromatic chlorination using SO2Cl2 leading to para/ortho ratios in excess of 50, the highest such ratio reported for this chlorinating agent. Model studies suggest that this significant para/ortho ratio results not just from steric effects but that considerable electronic influence can be detected. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00996-1

文献信息

• COMPOUNDS ACTING AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE
  申请人：Allergan, Inc.

  公开号：EP3424904A1

  公开（公告）日：2019-01-09

  The present invention provides a compound, that is a 1-(halo-2-[(2-hydrocarbyl or substituted hydrocarbyl)oxy]phenyl}methyl)-(fused bicyclic nitrogen heteroaryl) carboxylic acid or an ester or sulfonamide thereof. The compound may be represented by the following formula Wherein R1, R2, R3, R4 A, X, W, Z and Y are as defined in the specification. The compounds may be administered to treat DP, FP, EP1, TP and/or EP4 receptor-mediated diseases or conditions.

  本发明提供了一种化合物，它是 1-(卤代-2-[(2-氢羰基或取代羰基)氧基]苯基}甲基)-(融合双环氮杂芳基)羧酸或其酯或磺酰胺。该化合物可用下式表示 其中 R1、R2、R3、R4 A、X、W、Z 和 Y 如说明书中所定义。化合物可用于治疗 DP、FP、EP1、TP 和/或 EP4 受体介导的疾病或病症。
• On the para-selective chlorination of ortho-cresol
  作者：Emmanuelle A Bugnet、Adrian R Brough、Robert Greatrex、Terence P Kee

  DOI：10.1016/s0040-4020(02)00996-1

  日期：2002.9

  Merrifield-bound o-cresol undergoes electrophilic aromatic chlorination using SO2Cl2 leading to para/ortho ratios in excess of 50, the highest such ratio reported for this chlorinating agent. Model studies suggest that this significant para/ortho ratio results not just from steric effects but that considerable electronic influence can be detected. (C) 2002 Elsevier Science Ltd. All rights reserved.