Copper(II) catalyzed heterobenzylic C(sp3)-H activation: Two efficient halogenation methodologies towards heterobenzyl halides
作者:Wen Zhu Bi、Chen Qu、Xiao Lan Chen、Sheng Kai Wei、Ling Bo Qu、Shu Yun Liu、Kai Sun、Yu Fen Zhao
DOI:10.1016/j.tet.2018.02.058
日期:2018.4
readily prepared by the one-pot reaction of 2-methylquinolines with CuX (X = I, Br, Cl) and TBHP in CH3CN. A large variety of heterobenzyl iodides, including 2-iodomethylquinolines, 2-iodomethylquinoxalines, 2-iodiomethylbenzooxazole, and 2-iodiomethylbenzothiazole, were efficiently synthesized by one-pot reaction of 2-methylheterocycles with iodine in the presence of CuSO4·5H2O in CH3CN.
Continuous Flow Doebner–Miller Reaction and Isolation Using Continuous Stirred Tank Reactors
作者:Maruti B. Yadav、Sourabh Kulkarni、Ramesh A. Joshi、Amol A. Kulkarni
DOI:10.1021/acs.oprd.6b00179
日期:2016.9.16
Continuous flow Doebner–Miller synthesis of different quinaldines from respective anilines is demonstrated using sulfuric acid as a homogeneous catalyst. The extent of reaction was monitored for various parameters, namely, temperature, residence time, mole ratio of sulfuric acid to substrate, mole ratio of crotonaldehyde to substrate, and so forth. Continuous stirred reactors in series were used as
Synthesis of quinaldines and lepidines by a Doebner–Miller reaction under thermal and microwave irradiation conditions using phosphotungstic acid
作者:Ganesabaskaran Sivaprasad、Rengasamy Rajesh、Paramasivan T. Perumal
DOI:10.1016/j.tetlet.2006.01.034
日期:2006.3
A simple and efficient method has been developed for the synthesis of quinaldines and lepidines by a one-pot reaction of anilines with crotonaldehyde or methyl vinyl ketone usingphosphotungsticacid, a Keggins-type heteropolyacid, under both thermal and microwave irradiation conditions.
Acid-Activatable Michael-Type Fluorescent Probes for Thiols and for Labeling Lysosomes in Live Cells
作者:Chun-Guang Dai、Xiao-Jiao Du、Qin-Hua Song
DOI:10.1021/acs.joc.5b02041
日期:2015.12.18
A Michael addition is usually taken as a base-catalyzed reaction. Most fluorescentprobes have been designed to detect thiols in slightly alkaline solutions (pH 7–9). The sensing reactions of almost all Michael-type fluorescentprobes for thiols are faster in a high pH solution than in a low pH solution. In this work, we synthesized a series of 7-substituted 2-(quinolin-2-ylmethylene)malonic acids