NPI-2080

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: NPI-2080
• 英文别名: salinosporamide E；(1R,4R,5S)-1-[(S)-[(1S)-cyclohex-2-en-1-yl]-hydroxymethyl]-5-methyl-4-propyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione
• 化学式: C₁₆H₂₃NO₄
• 分子量: 293.363
• InChiKey: UIVOURYCXDWHCU-BFPXCNAZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  NPI-2062 在 sodium tetrahydroborate 、 copper(l) iodide 、 sodium iodide 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 水 、 丙酮 为溶剂， 反应 145.73h， 生成 NPI-2080
  参考文献：
  名称：

  WO2008/124699

  摘要：

  公开号：

文献信息

• TOTAL SYNTHESIS OF SALINOSPORAMIDE A AND ANALOGS THEREOF
  申请人：Ling Taotao

  公开号：US20090234137A1

  公开（公告）日：2009-09-17

  The present application relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing Salinosporamide A and its analogs that includes forming a compound of formula (VIII).

  本申请涉及某些化合物以及用于制备可用于化学和医药领域的某些化合物的方法。具体来说，本文描述了用于制备各种化合物和中间体的方法，以及这些化合物和中间体本身。更具体地，本文描述了一种合成Salinosporamide A及其类似物的方法，其中包括形成化合物的公式（VIII）。
• [3.2.0] Heterocyclic compounds and methods of using the same
  申请人：Potts Christine Barbara

  公开号：US20050288352A1

  公开（公告）日：2005-12-29

  Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

  本发明涉及具有抗癌，抗炎和抗微生物特性的I-VI式化合物及其衍生物和类似物，以及包括其中一种或多种化合物及其衍生物或类似物的组合物。还公开了包含这些化合物的药物组合物以及使用公开的化合物或药物组合物治疗癌症，炎症和微生物感染的方法。
• WO2007/130404
  申请人：——

  公开号：——

  公开（公告）日：——
• Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor
  作者：Venkat R. Macherla、Scott S. Mitchell、Rama Rao Manam、Katherine A. Reed、Ta-Hsiang Chao、Benjamin Nicholson、Gordafaried Deyanat-Yazdi、Bao Mai、Paul R. Jensen、William F. Fenical、Saskia T. C. Neuteboom、Kin S. Lam、Michael A. Palladino、Barbara C. M. Potts

  DOI：10.1021/jm048995+

  日期：2005.6.1

  Salinosporamide A (1, NPI-0052) is a potent proteasome inhibitor in development for treating cancer. In this study, a series of analogues was assayed for cytotoxicity, proteasome inhibition, and inhibition of NF-kappa B activation. Marked reductions in potency in cell-based assays accompanied replacement of the chloroethyl group with unhalogenated substituents. Halogen exchange and cyclohexene ring epoxidation were well tolerated, while some stereochemical modifications significantly attenuated activity. These findings provide insights into structure-activity relationships within this novel series.
• Methods of using [3.2.0] heterocyclic compounds and analogs thereof
  申请人：Palladino Michael

  公开号：US20070004676A1

  公开（公告）日：2007-01-04

  Disclosed are methods of treating cancer comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula VI. The animal is a mammal, preferably a human or a rodent.