1-[bis(ethylthio)methyl]-4-acetylbenzene

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[bis(ethylthio)methyl]-4-acetylbenzene
• 化学式: C₁₃H₁₈OS₂
• 分子量: 254.417
• InChiKey: HMCNHCKNEUMWTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.39
• 重原子数：
  16.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  4-乙酰苯甲醛 、 乙硫醇 在 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate 、 scandium tris(trifluoromethanesulfonate) 作用下， 反应 1.0h， 以48%的产率得到1-[bis(ethylthio)methyl]-4-acetylbenzene
  参考文献：
  名称：

  Synthesis in ionic liquids only: access to α-oxo-γ-thio-esters via Mukaiyama coupling

  摘要：

  Ionic liquids are solvents general enough to conduct a multi-step process in organic synthesis. We show that both the preparation of starting materials (thioacetals and enoxysilane) as well as their coupling can be realized in such medium. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.024

文献信息

• Synthesis in ionic liquids only: access to α-oxo-γ-thio-esters via Mukaiyama coupling
  作者：Khouloud Jebri、Marie-Rose Mazières、Stéphanie Ballereau、Taïcir Ben Ayed、Jean-Christophe Plaquevent、Michel Baltas、Frédéric Guillen

  DOI：10.1016/j.tetlet.2014.01.024

  日期：2014.2

  Ionic liquids are solvents general enough to conduct a multi-step process in organic synthesis. We show that both the preparation of starting materials (thioacetals and enoxysilane) as well as their coupling can be realized in such medium. (C) 2014 Elsevier Ltd. All rights reserved.