2-((4-(methylsulfonyl)phenyl)(2-oxopyrrolidin-1-yl)methyl)-1-phenylbutane-1,3-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-((4-(methylsulfonyl)phenyl)(2-oxopyrrolidin-1-yl)methyl)-1-phenylbutane-1,3-dione
• 英文别名: 2-[(4-Methylsulfonylphenyl)-(2-oxopyrrolidin-1-yl)methyl]-1-phenylbutane-1,3-dione；2-[(4-methylsulfonylphenyl)-(2-oxopyrrolidin-1-yl)methyl]-1-phenylbutane-1,3-dione
• 化学式: C₂₂H₂₃NO₅S
• 分子量: 413.494
• InChiKey: IHGZCXWFHVUWRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  97
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(ethoxy(4-(methylsulfonyl)phenyl)methyl)pyrrolidin-2-one 、 1-苯基-1,3-丁二酮 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 氯仿 为溶剂， 反应 24.0h， 以87%的产率得到2-((4-(methylsulfonyl)phenyl)(2-oxopyrrolidin-1-yl)methyl)-1-phenylbutane-1,3-dione
  参考文献：
  名称：

  Cu(OTf)2 catalyzed cross-coupling reaction of 1,3-dicarbonyl derivatives with 2-oxo-1-pyrrolidine compounds

  摘要：

  An efficient method for the cross-coupling reactions of 1,3-dicarbonyl compounds with 2-oxo-1-pyrrolidine compounds 1 was developed. Cu(OTf)(2) catalyzed C-C bond forming reactions using substrates 1 with 1,3-dicarbonyl compounds in chloroform, providing the corresponding compounds of 2-oxo-1-pyrrolidine bearing 1,3-dicarbonyl moiety in moderate to good yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.07.017

文献信息

• Cu(OTf)2 catalyzed cross-coupling reaction of 1,3-dicarbonyl derivatives with 2-oxo-1-pyrrolidine compounds
  作者：Hai-Yan Xu、Shun-Yi Wang、Ran Jiang、Xiao-Ping Xu、Xue-Qiang Chu、Shun-Jun Ji

  DOI：10.1016/j.tet.2012.07.017

  日期：2012.9

  An efficient method for the cross-coupling reactions of 1,3-dicarbonyl compounds with 2-oxo-1-pyrrolidine compounds 1 was developed. Cu(OTf)(2) catalyzed C-C bond forming reactions using substrates 1 with 1,3-dicarbonyl compounds in chloroform, providing the corresponding compounds of 2-oxo-1-pyrrolidine bearing 1,3-dicarbonyl moiety in moderate to good yields. (C) 2012 Elsevier Ltd. All rights reserved.