3-(2-bromophenyl)-[1,2,4]triazolo[4,3-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(2-bromophenyl)-[1,2,4]triazolo[4,3-a]pyridine
• 英文别名: 3-(2-bromophenyl)[1,2,4]triazolo[4,3-a]pyridine
• 化学式: C₁₂H₈BrN₃
• 分子量: 274.12
• InChiKey: ZTYBGJWZYXGNQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-肼吡啶 、 邻溴苯甲醛 在 叔丁基过氧化氢 、 碘 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 1.0h， 以88%的产率得到3-(2-bromophenyl)-[1,2,4]triazolo[4,3-a]pyridine
  参考文献：
  名称：

  One-pot synthesis of N-fused 1,2,4-triazoles and related heterocycles via I2/TBHP-mediated oxidative C N bond formation

  摘要：

  A metal-free iodine/TBHP-mediated oxidative C-N bond formation for the one-pot synthesis of N-fused 1,2,4-triazoles and related heterocycles via cyclization has been developed. This reaction which is amenable to scale-up affords the corresponding products with good to excellent yields and tolerates a wide range of functional groups. (C) 2018 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2018.10.019

文献信息

• TBAI/TBHP-Catalyzed Synthesis of [1,2,4]Triazolo[4,3-a]pyridines and 3,5-Diaryl-1,2,4-oxadiazoles via Oxidative Cleavage of C=C Double Bond
  作者：S. L. Matcha、S. Vidavalur

  DOI：10.1134/s1070428021090141

  日期：2021.9

  Abstract A simple and efficient protocol has been described for the synthesis of [1,2,4]triazolo[4,3-a]pyri­dines and 3,5-disubstituted-1,2,4-oxadiazoles by reacting 2-hydrazinylpyridine and benzamidoximes, respec­tively, with styrenes via TBAI/TBHP-mediated oxidative cleavage of C=C bond under ligand- and metal-free conditions.

  摘要 通过 2-肼基吡啶和苯甲胺肟反应合成 [1,2,4] 三唑并 [4,3- a ] 吡啶和 3,5-二取代-1,2,4-恶二唑的简单有效的方案已被描述，分别在无配体和无金属条件下通过 TBAI/TBHP 介导的 C=C 键氧化裂解与苯乙烯。
• One-pot synthesis of N-fused 1,2,4-triazoles and related heterocycles via I2/TBHP-mediated oxidative C N bond formation
  作者：Yachuang Wu、Yifeng Yang、Yinliang Qi、Shimei Du、Yongsheng Zhang、Liang Ding、Yanfang Zhao

  DOI：10.1016/j.tetlet.2018.10.019

  日期：2018.11

  A metal-free iodine/TBHP-mediated oxidative C-N bond formation for the one-pot synthesis of N-fused 1,2,4-triazoles and related heterocycles via cyclization has been developed. This reaction which is amenable to scale-up affords the corresponding products with good to excellent yields and tolerates a wide range of functional groups. (C) 2018 Elsevier Ltd. All rights reserved.