1-bromo-5-methylcyclopentene

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: 1-bromo-5-methylcyclopentene
• 英文别名: Cyclopentene, 1-bromo-5-methyl-
• 化学式: C₆H₉Br
• 分子量: 161.041
• InChiKey: RUFKCOOQIXFLCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1-bromo-5-methylcyclopentene 、 3,4-二异丙氧基-3-环丁烯-1,2-二酮 、 丙基锂 在 叔丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 0.83h， 以68%的产率得到
  参考文献：
  名称：

  A Highly Abbreviated Synthesis of Pentalenene by Means of the Squarate Ester Cascade

  摘要：

  [GRAPHICS]The sequential addition of 5-methylcyclopentyllithium and propynyllithium to diisopropyl squarate results in the efficient formation of a functionalized angular triquinane having two of its five-membered rings substituted precisely as in the target sesquiterpene. Only seven additional steps are then required to access pentalenene.

  DOI：

  10.1021/ol020208k
• 作为产物：
  描述：

  methylcyclopentanone benzenesulfonylhydrazone 、 1,1,2,2-四氟-1,2-二溴乙烷 在 正丁基锂 、 四甲基乙二胺 作用下， 以 various solvent(s) 为溶剂， 以30%的产率得到1-bromo-5-methylcyclopentene
  参考文献：
  名称：

  A Highly Abbreviated Synthesis of Pentalenene by Means of the Squarate Ester Cascade

  摘要：

  [GRAPHICS]The sequential addition of 5-methylcyclopentyllithium and propynyllithium to diisopropyl squarate results in the efficient formation of a functionalized angular triquinane having two of its five-membered rings substituted precisely as in the target sesquiterpene. Only seven additional steps are then required to access pentalenene.

  DOI：

  10.1021/ol020208k

文献信息

• (2-((2-alkoxy)-phenyl)-cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives
  申请人：Giblin Paul Gerard Martin

  公开号：US20050239802A1

  公开（公告）日：2005-10-27

  Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R 1 , R 2 , R x , R 8 , R 9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.

  公式（I）的化合物或其药学上可接受的衍生物：其中A，R1，R2，Rx，R8，R9和n如规范中所定义，制备这种化合物的过程，包括这种化合物的制药组合物以及在医学中使用这种化合物的用途。
• A Highly Abbreviated Synthesis of Pentalenene by Means of the Squarate Ester Cascade
  作者：Leo A. Paquette、Feng Geng

  DOI：10.1021/ol020208k

  日期：2002.12.1

  [GRAPHICS]The sequential addition of 5-methylcyclopentyllithium and propynyllithium to diisopropyl squarate results in the efficient formation of a functionalized angular triquinane having two of its five-membered rings substituted precisely as in the target sesquiterpene. Only seven additional steps are then required to access pentalenene.