2-chloro-N-(pyridin-3-yl)-3-(trifluoromethyl)quinoline-8-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-chloro-N-(pyridin-3-yl)-3-(trifluoromethyl)quinoline-8-carboxamide
• 英文别名: 2-chloro-N-pyridin-3-yl-3-(trifluoromethyl)quinoline-8-carboxamide
• 化学式: C₁₆H₉ClF₃N₃O
• 分子量: 351.715
• InChiKey: DACDWAWJVDTEPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-chloro-N-(pyridin-3-yl)-3-(trifluoromethyl)quinoline-8-carboxamide 、 苯硼酸 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 2.0h， 以41%的产率得到2-phenyl-N-(pyridin-3-yl)-3-(trifluoromethyl)quinoline-8-carboxamide
  参考文献：
  名称：

  QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS

  摘要：

  公开号：

  EP2273992B1
• 作为产物：
  描述：

  3-氨基吡啶 、 2-chloro-3-trifluoromethyl-8-quinolinecarboxylic acid 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 以65%的产率得到2-chloro-N-(pyridin-3-yl)-3-(trifluoromethyl)quinoline-8-carboxamide
  参考文献：
  名称：

  QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS

  摘要：

  公开号：

  EP2273992B1

文献信息

• Quinolines and related analogs as sirtuin modulators
  申请人：Vu Chi B.

  公开号：US08685970B2

  公开（公告）日：2014-04-01

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了新颖的sirtuin调节化合物及其使用方法。这些sirtuin调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和疾病，包括与衰老或压力有关的疾病或疾病，糖尿病，肥胖症，神经退行性疾病，心血管疾病，血栓形成障碍，炎症，癌症和/或红斑病，以及需要增加线粒体活性的疾病或疾病。还提供了包含sirtuin调节化合物与另一种治疗剂的组合物。
• QUENOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS
  申请人：Sirtris Pharmaceuticals, Inc.

  公开号：EP2273992A1

  公开（公告）日：2011-01-19
• [EN] QUENOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS<br/>[FR] QUINOLÉINES ET ANALOGUES APPARENTÉS EN TANT QUE MODULATEURS DE SIRTUINE
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2009134973A1

  公开（公告）日：2009-11-05

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
• QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS
  申请人：GlaxoSmithKline LLC

  公开号：EP2273992B1

  公开（公告）日：2016-05-25