8,8-dimethyl-4-phenyl-1,2,3,3a,4,5,6,7,8,9-decahydropyrrolo[1,2-a]quinoline-5,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8,8-dimethyl-4-phenyl-1,2,3,3a,4,5,6,7,8,9-decahydropyrrolo[1,2-a]quinoline-5,6-dione
• 英文别名: 8,8-dimethyl-4-phenyl-2,3,3a,4,8,9-hexahydropyrrolo[1,2-a]quinoline-5,6(1H,7H)-dione；8,8-dimethyl-4-phenyl-2,3,3a,4,7,9-hexahydro-1H-pyrrolo[1,2-a]quinoline-5,6-dione
• 化学式: C₂₀H₂₃NO₂
• mdl: MFCD05258699
• 分子量: 309.408
• InChiKey: SVZNCMYWUAHIEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-二氢-2H-吡咯 、 2-(phenylacetyl)-5,5-dimethylcyclohexane-1,3-dione 以 甲醇 、 甲苯 为溶剂， 以65%的产率得到8,8-dimethyl-4-phenyl-1,2,3,3a,4,5,6,7,8,9-decahydropyrrolo[1,2-a]quinoline-5,6-dione
  参考文献：
  名称：

  Condensation of 2-Alkylcyclohexane-1,3-diones with Cyclic Azomethines

  摘要：

  Reaction of 2-acylcyclohexane-1,3-diones with 5- and 6-membered cyclic azomethines (3,4-dihydro-2H-pyrrole and 2,3,4,5-tetrahydropyridine) furnished derivatives of 2,3,3a,4,8,9-hexahydropyrrolo[1,2a]quinoline-5,6(1H,5aH)-dione and 3,4,4a,5,9,10-hexahydro-1H-pyrido[1,2-a]quinoline-6,7(2H,8H)-dione respectively. In reaction with 7-membered 3,4,5,6-tetrahydro-2H-azepine we failed to isolate polycyclic nitrogen-containing products.

  DOI：

  10.1023/b:rujo.0000045903.18108.84

文献信息

• Condensation of 2-Alkylcyclohexane-1,3-diones with Cyclic Azomethines
  作者：D.B. Rubinova、I.L. Rubinova

  DOI：10.1023/b:rujo.0000045903.18108.84

  日期：2004.8

  Reaction of 2-acylcyclohexane-1,3-diones with 5- and 6-membered cyclic azomethines (3,4-dihydro-2H-pyrrole and 2,3,4,5-tetrahydropyridine) furnished derivatives of 2,3,3a,4,8,9-hexahydropyrrolo[1,2a]quinoline-5,6(1H,5aH)-dione and 3,4,4a,5,9,10-hexahydro-1H-pyrido[1,2-a]quinoline-6,7(2H,8H)-dione respectively. In reaction with 7-membered 3,4,5,6-tetrahydro-2H-azepine we failed to isolate polycyclic nitrogen-containing products.