作者:Indranil Duttagupta、Koushik Goswami、Surajit Sinha
DOI:10.1016/j.tet.2012.07.014
日期:2012.9
Synthesis of five-, six-, seven-, eight-, and nine-membered cyclic α-hydrazino acids from a common starting material ‘diethylmalonate’ with 26, 16, 34, 13.5, and 13.33% overall yields is described. Sequential allylation or homoallylation and electrophilic amination followed by cyclization gave the desired rings. The methyl esters of eight- and nine-membered rings were synthesized by RCM and the corresponding
描述了从常见的起始原料“丙二酸二乙酯”以26、16、34、13.5和13.33%的总收率合成五元,六元,七元,八元和九元环状α-肼基酸。顺序烯丙基化或均烯丙基化和亲电胺化,然后环化,得到所需的环。通过RCM合成八元环和九元环的甲酯,并在DCM中的1 M BBr 3溶液存在下水解后生成相应的游离酸。