六氢哒嗪二盐酸盐 、 Dicaesio carbonate 、 4-氟萘-1-甲腈 在
氮气 、 水 作用下,
以
二甲基亚砜 为溶剂,
反应 16.0h,
以which resulted in the precipitation of a 5.6 g (80% yield) of the title compound as a yellow solid的产率得到4-(tetrahydro-1(2H)-pyridazinyl)-1-naphthalenecarbonitrile
参考文献:
名称:
Naphthalene Derivatives as Modulators of the Glucocorticoid Receptor
SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS
申请人:Dahmann Georg
公开号:US20130023502A1
公开(公告)日:2013-01-24
The invention relates to new substituted pyridinyl-pyrimidines of formula
1
wherein
ring A is a five-membered saturated or unsaturated carbocyclic ring which optionally comprises one, two or three heteroatoms each independently from each other selected from the group N, S and O,
wherein R
1
, R
2
, R
4
, R
3
, R
5
and R
6
are defined as in claim
1
and wherein ring A is further optionally substituted by one or two further substituents and the pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates and solvates of the aforementioned compounds.
[EN] PYRAZOLO [1, 5 -A] PYRIMIDINES AS ANTIVIRAL AGENTS<br/>[FR] PYRAZOLO[1,5-A]PYRIMIDINES EN TANT QU'AGENTS ANTIVIRAUX
申请人:GILEAD SCIENCES INC
公开号:WO2011163518A1
公开(公告)日:2011-12-29
The invention provides compounds of Formula I or Formula II: (I), (II) or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
[EN] ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS<br/>[FR] HÉTÉROCYCLES D'ARYLMÉTHYLIDÈNE COMME NOUVEAUX ANALGÉSIQUES
申请人:CHLORION PHARMA INC
公开号:WO2009097695A1
公开(公告)日:2009-08-13
The present invention relates to Arylmethylidene heterocycles, compositions comprising an Arylmethylidene heterocycle, and methods useful for treating or preventing pain comprising administering an effective amount of an Arylmethylidene heterocycle as depicted by the formula (Ia).The compounds, compositions, and methods of the invention are also useful for treating or preventing inflammation.
[EN] SPLICEOSTATIN ANALOGS<br/>[FR] ANALOGUES DE SPLICÉOSTATINE
申请人:PFIZER
公开号:WO2014068443A1
公开(公告)日:2014-05-08
The present invention is directed to novel cytotoxic spliceostatin analogs (I) and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
[EN] SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS<br/>[FR] PYRIDINYL-PYRIMIDINES SUBSTITUÉES ET LEUR UTILISATION EN TANT QUE MÉDICAMENTS
申请人:BOEHRINGER INGELHEIM INT
公开号:WO2012101013A1
公开(公告)日:2012-08-02
The invention relates to new substituted pyridinyl-pyrimidines of formula 1 wherein ring A is a five-membered saturated or unsaturated carbocyclic ring which optionally comprises one, two or three heteroatoms each independently from each other selected from the group N, S and O, wherein R1, R2, R4, R3, R5 and R6 are defined as in claim 1 and wherein ring A is further optionally substituted by one or two further substituents and the pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates and solvates of the aforementioned compounds.