六羟基蒽醌 | 82-12-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 中文名称: 六羟基蒽醌
• 英文名称: rufigallol
• 英文别名: 1,2,3,5,6,7-hexahydroxyanthraquinone；1,2,3,5,6,7-hexahydroxy-9,10-anthraquinone；1,2,3,5,6,7-hexahydroxyanthracene-9,10-dione
• CAS: 82-12-2
• 化学式: C₁₄H₈O₈
• 分子量: 304.213
• InChiKey: NEIMTOOWBACOHT-UHFFFAOYSA-N

物化性质

• 沸点：
  405.05°C (rough estimate)
• 密度：
  1.5387 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  156
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  六羟基蒽醌 在 硫酸 、 硼酸 、 mercury(II) oxide 作用下， 反应 2.0h， 生成 1,2,3,4,5,6,7,8-octahydroxy-9,10-anthraquinone
  参考文献：
  名称：

  Microwave-assisted synthesis of novel oligomeric rod-disc hybrids

  摘要：

  Microwave-assisted syntheses of five new oligomeric liquid crystals (LC) are reported for the first time consisting of rufigallol-based core attached to which 8-cyanobiphenyl units via flexible alkyl spacers. The synthesis of the target compounds was challenging since classical reactions failed to produce these hybrids. Chemical structures of these hybrids were determined by H-1 NMR, C-13 NMR, IR, UV spectroscopy and elemental analysis. The thermotropic liquid crystalline properties of these new compounds were investigated by polarizing optical microscopy (POM), differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.058
• 作为产物：
  描述：

  1,2,3,5,6,7-hexaacetoxy-anthraquinone 在 水 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 六羟基蒽醌
  参考文献：
  名称：

  Microwave-assisted synthesis of novel oligomeric rod-disc hybrids

  摘要：

  Microwave-assisted syntheses of five new oligomeric liquid crystals (LC) are reported for the first time consisting of rufigallol-based core attached to which 8-cyanobiphenyl units via flexible alkyl spacers. The synthesis of the target compounds was challenging since classical reactions failed to produce these hybrids. Chemical structures of these hybrids were determined by H-1 NMR, C-13 NMR, IR, UV spectroscopy and elemental analysis. The thermotropic liquid crystalline properties of these new compounds were investigated by polarizing optical microscopy (POM), differential scanning calorimetry (DSC) and X-ray diffractometry (XRD). (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.09.058

文献信息

• [EN] POLYMERIC HYPERBRANCHED CARRIER-LINKED PRODRUGS<br/>[FR] PROMÉDICAMENTS LIÉS À DES EXCIPIENTS POLYMÉRIQUES HYPERBRANCHÉS
  申请人：ASCENDIS PHARMA AS

  公开号：WO2013024048A1

  公开（公告）日：2013-02-21

  The present invention relates to water-soluble carrier-linked prodrugs of formula (I),wherein POL is a polymeric moiety,each Hyp is independently a hyperbranched moiety,each moiety SP is independently a spacer moiety, each L is independently a reversible prodrug linker moiety, m is 0 or 1, each n is independently an integer from 2 to 200 and each x is independently 0 or 1. It further relates to pharmaceutical compositions comprising said water- soluble carrier-linked prodrugs and methods of treatment.

  本发明涉及水溶性载体连接的前药，其化学式为（I），其中POL是聚合物基团，每个Hyp是独立的超支化基团，每个基团SP是独立的间隔基团，每个L是独立的可逆前药连接基团，m为0或1，每个n是独立的整数，范围从2到200，每个x是独立的0或1。此外，还涉及包含所述水溶性载体连接的前药的药物组合物和治疗方法。
• [EN] HIGH-LOADING WATER-SOLUBLE CARRIER-LINKED PRODRUGS<br/>[FR] PROMÉDICAMENTS LIÉS À DES EXCIPIENTS HYDROSOLUBLES DE FORTE CHARGE
  申请人：ASCENDIS PHARMA AS

  公开号：WO2013024047A1

  公开（公告）日：2013-02-21

  The present invention relates to water-soluble carrier-linked prodrugs of formula (I), wherein B, A and Hyp form the carrier, B is a branching core, each A is independently a poly(ethylene glycol)-based polymeric chain, each Hyp is independently a branched moiety, each SP is independently a spacer moiety, each L is independently a reversible prodrug linker moiety, each D is independendly a biologically active moiety, each x is independently 0 or 1, each m is independently an integer of from 2 to 64, n is an integer from 3 to 32; or the pharmaceutically acceptable salt thereof. It further relates to pharmaceutical compositions comprising said water-soluble carrier-linked prodrugs, their use asmedicament or diagnostic, and methods of treatment.

  本发明涉及水溶性载体连接的前药，其化学式为(I)，其中B、A和Hyp形成载体，B是一个分支核心，每个A独立地是一条聚乙二醇基聚合链，每个Hyp独立地是一个分支基团，每个SP独立地是一个间隔基团，每个L独立地是一个可逆前药连接基团，每个D独立地是一个生物活性基团，每个x独立地为0或1，每个m独立地是从2到64的整数，n是从3到32的整数；或其药学上可接受的盐。进一步涉及包括所述水溶性载体连接的前药的药物组合物，其用作药物或诊断，以及治疗方法。
• Syntheses and Mesogenic Properties of Dimers and Trimers Consisting of Triphenylene Donor and Anthraquinone Acceptor
  作者：Sanjay Kumar Varshney、Hiroki Nagayama、Veena Prasad、Hideo Takezoe

  DOI：10.1080/15421400903483908

  日期：2010.2.25

  microscope (POM) and differential scanning calorimetry (DSC). The dimers D-A(OH) having the spacer length similar to peripheral alkoxy chains exhibit the nematic (N) phase, whereas dimers D-A(OH) and D-A(OAc) having longer spacer length compared with peripheral alkoxy chains exhibit the columnar (Col) phase. The trimers exhibit N or Col mesophases, as confirmed by X-ray diffraction (XRD) studies, according

  报道了新二聚体的合成和液晶特性，其具有通过柔性间隔物连接到单官能化蒽醌受体 (A) 核 DA 的三亚苯供体 (D) 核。这些二聚体具有羟基 (DA(OH)) 或乙酰氧基 (DA(OAc)) 官能团。此处还报告了线性三聚体 DAD。这些二聚体和三聚体的化学结构通过光谱和光谱分析表征。通过偏光显微镜（POM）和差示扫描量热法（DSC）研究液晶性质。间隔长度与外围烷氧基链相似的二聚体 DA(OH) 呈现向列 (N) 相，而间隔长度比外围烷氧基链长的二聚体 DA(OH) 和 DA(OAc) 呈现柱状 (Col) 相. 根据与 DA 中类似的规则，如 X 射线衍射 (XRD) 研究所证实的，三聚体表现出 N 或 Col 中间相。因此，间隔长度和官能团对分子自组装的影响更大，从而表现出液晶特性。值得注意的是，这些二聚体和三聚体中的一些在室温下显示出 N 或 Col 相。据我们所知，这是第一个具有非分支但正常外围链的分子。
• Room-temperature electron-deficient discotic liquid crystals: facile synthesis and mesophase characterization
  作者：Hari Krishna Bisoyi、Sandeep Kumar

  DOI：10.1039/b804100h

  日期：——

  Two novel series of rufigallol-based room-temperature discotic liquid crystals have been designed and synthesized using microwave dielectric heating within a few minutes in good yield. The chemical structures of all the compounds have been characterized using spectral techniques and elemental analysis. The mesophase behaviors of all the compounds have been investigated by polarizing optical microscopy

  使用微波介电加热在几分钟内以高收率设计并合成了两种新的基于三氟甲酚的室温圆盘液晶。所有化合物的化学结构已使用光谱技术进行了表征，并且元素分析。所有化合物的中间相行为已通过偏光光学显微镜 和 差示扫描量热法。这些化合物的中间相的柱状六方结构已经借助X射线衍射 学习。
• [EN] RELEASABLE CONJUGATES<br/>[FR] CONJUGUÉS LIBÉRABLES
  申请人：QUIAPEG PHARMACEUTICALS AB

  公开号：WO2018163131A1

  公开（公告）日：2018-09-13

  The present application provides compounds of Formula (B), or pharmaceutically acceptable salts thereof, wherein D is a residue of a biologically active drug, which underdo hydrolysis under physiological conditions to release the biologically active drug and which are useful in the treatment of disorders that could be beneficially treated with the drug.

  本申请提供了化合物的公式（B），或其药用盐，其中D是生物活性药物的残留物，在生理条件下经过水解释放出生物活性药物，并且对可能受益于该药物治疗的疾病具有用处。