4-(allyloxy)-3-methyl-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(allyloxy)-3-methyl-4-oxobutanoic acid
• 英文别名: 3-Methyl-4-oxo-4-prop-2-enoxybutanoic acid
• 化学式: C₈H₁₂O₄
• 分子量: 172.181
• InChiKey: ZXSOKGOTCQHLMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙烯酸甲基烯丙酯 、 potassium formate 在 4DPAIPN 、 硫代水杨酸甲酯 作用下， 以 二甲基亚砜 为溶剂， 反应 2.0h， 以74%的产率得到4-(allyloxy)-3-methyl-4-oxobutanoic acid
  参考文献：
  名称：

  通过硫醇催化的甲酸跨活化烯烃的光诱导加氢羧化

  摘要：

  在此，我们公开了一种从甲酸盐和烯烃制备羧酸的新光化学方法。这种氧化还原中性的加氢羧化反应在多种功能化烯烃底物上以高产率进行，具有优异的区域选择性。这种操作简单的程序可以很容易地在低光催化剂负载（0.01% 光催化剂）下批量缩放。此外，这种新反应可以利用市售的甲酸盐碳同位素来直接合成同位素标记的羧酸。机理研究支持涉及硫醇催化自由基链过程的工作模型，其中来自甲酸盐的原子通过CO 2 •–作为关键的反应中间体传递穿过烯烃底物。

  DOI：

  10.1021/jacs.1c07562

文献信息

• Amide Linkage Cyclic Natriuretic Peptide Constructs
  申请人：Sharma Shubh D.

  公开号：US20100035821A1

  公开（公告）日：2010-02-11

  Cyclic constructs which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and a cyclic linkage including one or two amide bonds, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.

  具有环状结构的构造物，可以与利钠肽受体结合，包括多个氨基酸残基，至少包括一个如下式I所示的氨基酸代用物：其中，R、R'、Q、Y、W、Z、J、x和n的定义如规范中所述，以及包括一个或两个酰胺键的环状连接，包括这种环状构造物的制药组合物，以及治疗充血性心力衰竭或其他需要诱导抗高血压、心血管、肾脏或内分泌效应的情况、综合征或疾病的方法。
• Peptidic Constructs with Amino Acid Surrogates
  申请人：SHARMA SHUBH D.

  公开号：US20110263818A1

  公开（公告）日：2011-10-27

  Peptidic constructs including at least one ring-constrained amino acid surrogate of formula I: where R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , and y are as defined in the specification, and a plurality of amino acid residues.

  含有至少一个环限制性氨基酸替代物I的肽构建物，其中R1、R2、R3、R4、R5、R6a、R6b、R7和y如规范中定义，以及多个氨基酸残基。
• JPH07258149A
  申请人：——

  公开号：JPH07258149A

  公开（公告）日：1995-10-09
• Uses of Natriuretic Peptide Constructs
  申请人：PALATIN TECHNOLOGIES, INC.

  公开号：US20130045928A1

  公开（公告）日：2013-02-21

  Use of constructs which bind to one or more natriuretic peptide receptors and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, for the prophylaxis or treatment of airway diseases, including but not limited to inflammation-related airway diseases, acute asthma or COPD, methods of prophylaxis and treatment of airway diseases and pharmaceutical compositions and formulations for the prophylaxis or treatment of airway diseases.
• Replacement Therapy for Natriuretic Peptide Deficiencies
  申请人：Palatin Technologies, Inc.

  公开号：US20160354443A1

  公开（公告）日：2016-12-08

  Use and methods of use of natriuretic peptide mimetics which bind to and activate natriuretic peptide receptor A in patients with a defect, condition, syndrome, disease or mutation resulting in a functional active ANP 99-126 deficiency, for treatment or prophylaxis of cardiovascular disease, including but not limited to hypertension, acute coronary syndrome, cardiomyopathy, cardiac remodeling, left-ventricular hypertrophy, congestive heart failure, heart failure, high blood pressure and coronary artery disease, including use of mimetics with a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification.