3-(4-(4-(3,5-dinitrobenzoyl)piperazine-1-yl)butoxy)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromene-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-(4-(4-(3,5-dinitrobenzoyl)piperazine-1-yl)butoxy)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromene-4-one
• 英文别名: 3-[4-[4-(3,5-Dinitrobenzoyl)piperazin-1-yl]butoxy]-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one；3-[4-[4-(3,5-dinitrobenzoyl)piperazin-1-yl]butoxy]-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one
• 化学式: C₃₅H₃₈N₄O₁₃
• 分子量: 722.706
• InChiKey: DTNWDHJIXOYQRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  52
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  197
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  3-hydroxy-3',4',5',5,7-pentamethoxymyricetin 在 potassium carbonate 、 三乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 36.5h， 生成 3-(4-(4-(3,5-dinitrobenzoyl)piperazine-1-yl)butoxy)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromene-4-one
  参考文献：
  名称：

  Discovery of new chromen-4-one derivatives as telomerase inhibitors through regulating expression of dyskerin

  摘要：

  A series of new trimethoxyphenyl-4H-chromen derivatives as telomerase inhibitors through regulation dyskerin were designed and synthesised. The anticancer activity assay in vitro showed that compound 5i 3-(4-(4-isonicotinoylpiperazin-1-yl)butoxy)-5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one exhibited high activity against Hela, SMMC-7721, SGC-7901, U87 and HepG2 cell lines. Compound 5i also showed potent inhibitory activity against telomerase. The further results confirmed this title compound could significantly improve pathological changes induced rat hepatic tumor in vivo. Preliminary mechanisms showed that compound 5i inhibited telomerase activity through decrease expression of dyskerin.

  DOI：

  10.1080/14756366.2018.1466881