2-(4-chlorophenyl)-7-methyl[1,2,4]triazolo[1,5-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-chlorophenyl)-7-methyl[1,2,4]triazolo[1,5-a]pyridine
• 英文别名: 2-(4-Chlorophenyl)-7-methyl-[1,2,4]triazolo[1,5-a]pyridine
• 化学式: C₁₃H₁₀ClN₃
• 分子量: 243.695
• InChiKey: BUESTRDXJMCDPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氯苯甲腈 、 1-amino-4-methylpyridin-1-ium 2,4,6-trimethylbenzenesulfonate 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 以66%的产率得到2-(4-chlorophenyl)-7-methyl[1,2,4]triazolo[1,5-a]pyridine
  参考文献：
  名称：

  Non-steroidal Pregnancy-Terminating Agents: Design, Synthesis and Structure–Activity Relationships of 2-Aryl-1,2,4-triazolo[1,5-a]pyridine

  摘要：

  The syntheses and the pregnancy-terminating activity relationships of compounds 5a-n are reported. Compounds 5b and 5l are found to be more potent than DL-111-a known drug having effective pregnancy-terminating activity in vitro. Further research shows compounds 5b and 5l have the same activity as DL-111 in vivo. We also found an exciting result that they have excellent anti-implantation activity after oral administration. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00399-2

文献信息

• PhI(OAc)2-Mediated Regioselective Synthesis of 5-Guanidino-1,2,4-thiadiazoles and 1,2,4-Triazolo[1,5-a]pyridines via Oxidative N–S and N–N Bond Formation
  作者：Tumula Nagaraju、Palakodety Radha Krishna、Balasubramanian Sridhar、Nakka Mangarao

  DOI：10.1055/s-0037-1611854

  日期：2019.10

  construction of biologically important 5-guanidino-1,2,4-thiadiazole and 1,2,4-triazolo[1,5-a]pyridine derivatives has been developed. This new protocol involves the phenyliodine(III) diacetate [PhI(OAc)2]-mediated oxidative cyclization of thioureas/2-aminopyridines and imidates via N–S and N–N bond formation at ambient temperature. This method furnishes the versatile 5-guanidino-1,2,4-thiadiazoles and 1

  抽象的 已经开发了一种有效且快速的方法，用于构建生物学上重要的5-胍基-1,2,4-噻二唑和1,2,4-三唑并[1,5- a ]吡啶衍生物。该新方案涉及苯乙酸碘（III）双乙酸盐[PhI（OAc）2 ]介导的硫脲/ 2-氨基吡啶的氧化环化作用，并在环境温度下通过NS和NS键形成酰亚胺。该方法以可扩展的方式高效，优异的区域选择性提供了通用的5-胍基-1,2,4-噻二唑和1,2,4-三唑并[1,5- a ]吡啶。 已经开发了一种有效且快速的方法，用于构建生物学上重要的5-胍基-1,2,4-噻二唑和1,2,4-三唑并[1,5- a ]吡啶衍生物。该新方案涉及苯乙酸碘（III）双乙酸盐[PhI（OAc）2 ]介导的硫脲/ 2-氨基吡啶的氧化环化作用，并在环境温度下通过NS和NS键形成酰亚胺。该方法以可扩展的方式高效，优异的区域选择性提供了通用的5-胍基-1,2,4-噻二唑和1,2,4-三唑并[1,5-
• A green polyol approach for the synthesis of Cu₂O NPs adhered on graphene oxide: a robust and efficient catalyst for 1,2,4-triazole and imidazo[1,2-<i>a</i>]pyridine synthesis
  作者：Shelly Kujur、Shruti Verma、Akash Kumar、Richa Sharma、Devendra Deo Pathak

  DOI：10.1039/d2nj00831a

  日期：——

  method” is reported for the synthesis of Cu2O nanoparticles (NPs) immobilized on graphene oxide (Cu2O-GO), for the first time. The composition of the synthesised composite was characterized by FT-IR, Raman, PXRD, FESEM, high-resolution TEM, XPS, TGA and ICP-MS analysis. Its catalytic application, as a novel heterogeneous catalyst, has been investigated in the solvent-free synthesis of a series of pharmaceutically

  首次报道了一种绿色“多元醇法”用于合成固定在氧化石墨烯 (Cu 2 O-GO)上的 Cu 2 O 纳米粒子 (NPs) 。通过FT-IR、Raman、PXRD、FESEM、高分辨率TEM、XPS、TGA和ICP-MS分析对合成的复合材料的组成进行了表征。其作为一种新型非均相催化剂的催化应用已被研究用于无溶剂合成一系列药学上重要的含氮杂环，即。1,2,4-三唑和咪唑[1,2- a]吡啶。该复合材料显示出广泛的底物范围和广泛的官能团弹性。这种绿色方法涉及使用廉价的反应物、适中的温度和无溶剂条件，并提供出色的产品收率。该复合材料通过过滤从反应混合物中回收，并且可以重复使用多达五个循环，而其对两个反应的催化活性都没有任何明显损失。
• Non-steroidal Pregnancy-Terminating Agents: Design, Synthesis and Structure–Activity Relationships of 2-Aryl-1,2,4-triazolo[1,5-a]pyridine
  作者：Tao Liu、Yongzhou Hu

  DOI：10.1016/s0960-894x(02)00399-2

  日期：2002.9

  The syntheses and the pregnancy-terminating activity relationships of compounds 5a-n are reported. Compounds 5b and 5l are found to be more potent than DL-111-a known drug having effective pregnancy-terminating activity in vitro. Further research shows compounds 5b and 5l have the same activity as DL-111 in vivo. We also found an exciting result that they have excellent anti-implantation activity after oral administration. (C) 2002 Elsevier Science Ltd. All rights reserved.