2-(4-Chlorophenyl)-4-(4-methylphenyl)-6-phenylpyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(4-Chlorophenyl)-4-(4-methylphenyl)-6-phenylpyrimidine
• 化学式: C₂₃H₁₇ClN₂
• 分子量: 356.854
• InChiKey: BWEPZBFQMOMPHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(1-Chlorobenzyl)-2-(4-chlorophenyl)-5-(4-methylphenyl)imidazoline 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 以85%的产率得到2-(4-Chlorophenyl)-4-(4-methylphenyl)-6-phenylpyrimidine
  参考文献：
  名称：

  Synthesis of amino acids and related compounds. 42. A novel transformation of imidazolines into 2,4,6-trisubstituted pyrimidine derivatives

  摘要：

  2,5-Diaryl-4-(chloromethyl)imidazoline derivatives 5a-g, obtained from N-acyl-alpha-amino ketone derivatives 1, were rearranged with sodium hydride in dimethylformamide. Spontaneous air oxidation led to 2,4-di- and 2,4,6-triarylpyrimidine derivatives 6a-g in good yields.

  DOI：

  10.1021/jo00075a032

文献信息

• Microwave-assisted simple, one-pot, four-component synthesis of 2,4,6-triarylpyrimidines under solvent-free conditions
  作者：Mehdi Adib、Niusha Mahmoodi、Mohammad Mahdavi、Hamid Reza Bijanzadeh

  DOI：10.1016/j.tetlet.2006.10.090

  日期：2006.12

  2,4,6-Triarylpyrimidines are synthesized via a simple, one-pot, four-component reaction between aryl methyl ketones, benzaldehydes, aromatic nitriles, and hydroxylamine under microwave irradiation and solvent-free conditions in good to excellent yields. (c) 2006 Published by Elsevier Ltd.