6-(2-methoxyethoxy)hex-1-ene

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(2-methoxyethoxy)hex-1-ene
• 化学式: C₉H₁₈O₂
• mdl: MFCD11553790
• 分子量: 158.241
• InChiKey: DHUGSIYESDUAAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.777
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(2-methoxyethoxy)hex-1-ene 在 [RuHCl(CO)(PPh₃)₃] 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  金属催化的ω-Ene不饱和醚的远程官能化：向功能化的乙烯基物种迈进。

  摘要：

  钌催化的链走与ω-烯基醚的镍催化的交叉偶联反应相结合，为官能化乙烯基物种提供了独特的入口。此转换通过演示涉及无关位点的​​两个独立反应的兼容性，说明了远程功能化的功能和灵活性。

  DOI：

  10.1002/anie.201802434
• 作为产物：
  描述：

  乙二醇甲醚 、 6-溴-1-己烯 在 potassium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以75%的产率得到6-(2-methoxyethoxy)hex-1-ene
  参考文献：
  名称：

  金属催化的ω-Ene不饱和醚的远程官能化：向功能化的乙烯基物种迈进。

  摘要：

  钌催化的链走与ω-烯基醚的镍催化的交叉偶联反应相结合，为官能化乙烯基物种提供了独特的入口。此转换通过演示涉及无关位点的​​两个独立反应的兼容性，说明了远程功能化的功能和灵活性。

  DOI：

  10.1002/anie.201802434

文献信息

• [EN] COMPOUNDS THAT INHIBIT MCL-1 PROTEIN<br/>[FR] COMPOSÉS INHIBANT LA PROTÉINE MCL-1
  申请人：AMGEN INC

  公开号：WO2017147410A1

  公开（公告）日：2017-08-31

  Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

  本文提供了髓样细胞白血病1蛋白（Mcl-1）抑制剂，其制备方法，相关的药物组合物，以及使用这些物质的方法。例如，本文提供了化合物I的公式，及其药用盐和含有这些化合物的药物组合物。本文提供的化合物和组合物可以用于治疗癌症等疾病或症状。
• Evidence for new surface organotin and germanium complexes with functional groups grafted at the surface of Pt and Rh
  作者：E. Tena、J.P. Candy、M.F. Cornil、B. Jousseaume、M. Spagnol、J.M. Basset

  DOI：10.1016/s1381-1169(99)00281-2

  日期：1999.10

  It has been previously demonstrated that reaction of organometallic compounds with group VIII metallic surfaces can lead to grafted organometallic fragments with well defined structures, The presence of remaining alkyl groups on the catalytic surface was demonstrated by various physical and chemical techniques (EXAFS, Magnetic measurements, I.R. spectroscopy, Mossbauer, Thermoreduction, etc.). Surface organometallic complexes with an average formula M-s[M'R-x](y) (M = Ph, Pt, Ni; M' = Sn, Ge, Si, Se; R = Me, Et, Bu) were proposed. The impact of the presence of these alkyl groups on the selectivity and activity for various catalytic reactions is a subject of important investigations. in this work, we demonstrate that organometallic fragments with functional groups can also be grafted on a platinum or rhodium surface. We will describe the synthesis of RxM'R-4-x(f) (M' = Sn or Ge; R = H or Bu and R-f=(CH2)(3)OH, (CH2)(3)OMe, (CH2)(3)O(CH2)(2)O(CH2)(2)OMe, or (CH2)(4)OH) and the kinetics of the reaction under atmospheric pressure of hydrogen with the silica supported platinum or rhodium catalysts. In every case, the hydrogenolysis of the organometallic complexes is not total and some organometallic fragments with functional groups remain on the surface. With R-f = (CH2)(3)OH, M = Rh, M' = Sn, on average, the grafted organometallic fragment can be formulated as: Rh-5[SnBu0.4R0.4f](y)/SiO2. With R-f= (CH2)(3)O(CH2)(2)O(CH2)(2)OMe, M = Rh, Pt, M' = Sn, on average, the grafted organometallic fragment can be formulated as: Pt-s[SnBu0.6R0.5f](0.43)/SiO2 or Rh-s[SnR0.6f](0.6)/SiO2. With(CH2)(3)OMe, M = Rh, Pt, M' = Sn, there is formation of a grafted organometallic fragment which can be formulated on average as: Rh-s[HxSnR0.9f](0.9)/SiO2 and Pt-s[HxSnR1.2f](0.9)/SiO2. With R-f = (CH2)(4)OH, M = Rh, Pt, M' = Ge, an average formula can be obtained as: Pt-s[Ge(H)(x)R-1(f)](0.6)/SiO2, Rh-s[Ge(H)(x)R-0.9(f)](0.6)/SiO2. Catalytic properties of these new material is under investigation. (C) 1999 Elsevier Science B.V. All rights reserved.
• Metal‐Catalyzed Remote Functionalization of ω‐Ene Unsaturated Ethers: Towards Functionalized Vinyl Species
  作者：Guo‐Ming Ho、Lina Judkele、Jeffrey Bruffaerts、Ilan Marek

  DOI：10.1002/anie.201802434

  日期：2018.7.2

  The combined ruthenium‐catalyzed chain walking with the nickel‐catalyzed cross‐coupling reaction of ω‐alkenyl ethers provide a unique entry to functionalized vinyl species. This transformation illustrates the power and flexibility of remote functionalization by demonstrating the compatibility of two independent reactions involving unrelated sites.

  钌催化的链走与ω-烯基醚的镍催化的交叉偶联反应相结合，为官能化乙烯基物种提供了独特的入口。此转换通过演示涉及无关位点的​​两个独立反应的兼容性，说明了远程功能化的功能和灵活性。