3,3'-bis(morpholino)biphenyl

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3,3'-bis(morpholino)biphenyl
• 英文别名: 4-[3-(3-Morpholin-4-ylphenyl)phenyl]morpholine；4-[3-(3-morpholin-4-ylphenyl)phenyl]morpholine
• 化学式: C₂₀H₂₄N₂O₂
• 分子量: 324.423
• InChiKey: JCTLXCFLFLXIDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(3-氯苯基)吗啉 在 bis(acetylacetonate)nickel(II) 、 aluminium(III) acetylacetonate 苯乙烯 、 2,2'-联吡啶 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以83%的产率得到3,3'-bis(morpholino)biphenyl
  参考文献：
  名称：

  An efficient route to biaryls from aryl halides catalysed by subnanometrical 2,2′-bipyridine liganded Ni–Al clusters

  摘要：

  It has been shown that the new 2,2'-bipyridine liganded Ni-Al bimetallic clusters are efficient in promoting the catalytic homocoupling of (het)aryl chlorides and bromides. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)01018-8

文献信息

• Nickel-catalysed sequential amination of aryl- and heteroaryl di- and trichlorides
  作者：Christophe Desmarets、Raphaël Schneider、Yves Fort

  DOI：10.1016/s0040-4020(01)00730-x

  日期：2001.9

  Unsymmetrical 1,3-diaminobenzenes and diaminopyridines were efficiently prepared by reaction of 3-chloroanilines and chloroaminopyridines with amines via a nickel-catalysed amination. The Ni/2,2′-bipyridine catalyst is also effective for the sequential amination of aryl trichlorides. After a first selective monoamination of 1,3,5-trichlorobenzene, the obtained 3,5-dichloroanilines were subsequently transformed

  通过使3-氯苯胺和氯氨基吡啶与镍通过胺催化的胺化反应有效地制备了不对称的1，3-二氨基苯和二氨基吡啶。Ni / 2，2'-联吡啶催化剂对于芳基三氯化物的顺序胺化也是有效的。在对1,3,5-三氯苯进行第一次选择性单胺化之后，随后将获得的3,5-二氯苯胺转化为新型且不对称的1,3,5-三氨基苯。
• An efficient route to biaryls from aryl halides catalysed by subnanometrical 2,2′-bipyridine liganded Ni–Al clusters
  作者：Fabien Massicot、Raphaël Schneider、Yves Fort、Sandra Illy-Cherrey、Olivier Tillement

  DOI：10.1016/s0040-4020(00)01018-8

  日期：2001.1

  It has been shown that the new 2,2'-bipyridine liganded Ni-Al bimetallic clusters are efficient in promoting the catalytic homocoupling of (het)aryl chlorides and bromides. (C) 2001 Elsevier Science Ltd. All rights reserved.