1-(1-phenylethyl)-2,4,5-triphenyl imidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(1-phenylethyl)-2,4,5-triphenyl imidazole
• 英文别名: 2,4,5-triphenyl-1-(1-phenylethyl)-1H-imidazole；2,4,5-Triphenyl-1-(1-phenylethyl)imidazole
• 化学式: C₂₉H₂₄N₂
• 分子量: 400.523
• InChiKey: LTJPFUSNSXNJTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯甲醛 、 联苯甲酰 、 α-苯乙胺 在 三乙烯二胺 、 ammonium acetate 作用下， 以 叔丁醇 为溶剂， 以70%的产率得到1-(1-phenylethyl)-2,4,5-triphenyl imidazole
  参考文献：
  名称：

  DABCO是一种温和高效的催化体系，可通过多组分缩合策略合成高度取代的咪唑

  摘要：

  通过多组分缩合策略缩合1,2-二羰基化合物，醛和乙酸铵或胺，开发了一种简单高效的合成高度取代的咪唑的方法。本方法使取代的咪唑的收率良好至优异。

  DOI：

  10.1016/j.tetlet.2010.07.128

文献信息

• DABCO as a mild and efficient catalytic system for the synthesis of highly substituted imidazoles via multi-component condensation strategy
  作者：S. Narayana Murthy、B. Madhav、Y.V.D. Nageswar

  DOI：10.1016/j.tetlet.2010.07.128

  日期：2010.10

  A simple and efficient protocol for the synthesis of highly substituted imidazoles is developed through the condensation of 1,2-dicarbonyl compound, aldehyde, and ammonium acetate or amine via multi-component condensation strategy. The present method gives good to excellent yields of substituted imidazoles.

  通过多组分缩合策略缩合1,2-二羰基化合物，醛和乙酸铵或胺，开发了一种简单高效的合成高度取代的咪唑的方法。本方法使取代的咪唑的收率良好至优异。
• A novel one-pot synthesis of tetrasubstituted imidazoles under solvent-free conditions and microwave irradiation
  作者：Saeed Balalaie、Mohammed M Hashemi、Maryam Akhbari

  DOI：10.1016/s0040-4039(03)00018-2

  日期：2003.2

  The one-pot, three-component condensation of benzil, benzonitrile derivatives and primary amines on the surface of silica gel under solvent-free conditions and microwave irradiation provided tetrasubstituted imidazoles in high yields.

  在无溶剂条件下和微波辐射下，苯甲腈，苄腈衍生物和伯胺在硅胶表面上的一锅三组分缩合反应可高产率提供四取代的咪唑。
• A Solvent-Free Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Using Molecular Iodine as Catalyst
  作者：Yi-Ming Ren、Chun Cai

  DOI：10.3184/030823410x12659021476402

  日期：2010.3

  An efficient method for the synthesis of 1,2,4,5-tetrasubstituted imidazoles by three-component condensation of benzil, benzonitrile derivatives and primary amines under solvent-free conditions using molecular iodine as catalyst is described with high product yields. The significant features of the iodine-catalysed condensation are operational simplicity, inexpensive reagents, high yield of products and use of non-toxic reagents.

  以分子碘为催化剂，描述了一种在无溶剂条件下通过三组分缩合合成 1,2,4,5-四取代咪唑的高效方法，该方法以苯偶酰、苯甲腈衍生物和伯胺为原料，产品收率高。碘催化缩合反应的显著特点是操作简单、试剂便宜、产品收率高和使用无毒试剂。
• A novel bioglycerol-based recyclable carbon catalyst for an efficient one-pot synthesis of highly substituted imidazoles
  作者：K. Ramesh、S. Narayana Murthy、K. Karnakar、Y.V.D. Nageswar、Kukuma Vijayalakhshmi、Bethala L.A. Prabhavathi Devi、R.B.N. Prasad

  DOI：10.1016/j.tetlet.2011.12.092

  日期：2012.2

  The new bioglycerol-based carbon catalyst acts as an efficient, readily available, and reusable catalyst for the synthesis of 2,4,5-trisubstituted imidazoles/1,2,4,5-tetrasubstituted imidazoles, when aromatic aldehyde, ammonium acetate/amine, and 1,2-diketone are reacted in acetonitrile. (C) 2011 Elsevier Ltd. All rights reserved.