diisopropyl 2-(cyclohexylmethylidene)malonate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: diisopropyl 2-(cyclohexylmethylidene)malonate
• 英文别名: Dipropan-2-yl 2-(cyclohexylmethylidene)propanedioate
• 化学式: C₁₆H₂₆O₄
• 分子量: 282.38
• InChiKey: ONSHPAPBFNOXMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  硝基丙烷 、 diisopropyl 2-(cyclohexylmethylidene)malonate 在 chiral ammonium bromide 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 10.0h， 生成 diisopropyl 2-(1-cyclohexyl-2-nitrobutyl)malonate 、 diisopropyl 2-(1-cyclohexyl-2-nitrobutyl)malonate 、 diisopropyl 2-(1-cyclohexyl-2-nitrobutyl)malonate
  参考文献：
  名称：

  使用 N-螺手性溴化铵的高效相转移催化将硝基烷烃高度对映选择性共轭加成到亚烷基丙二酸酯

  摘要：

  硝基烷烃与亚烷基丙二酸酯的高度对映选择性共轭加成首次通过利用 N-螺 C2-对称手性溴化季铵 1 的有效相转移催化实现。例如，简单混合硝基丙烷 (2, R1 = Et )、二异丙基苄基二烯丙二酸酯 (3, R2 = Ph)、Cs2CO3 (1 当量) 和 (S,S)-1 (1 mol%) 在甲苯中在 0 摄氏度下 2.5 小时产生所需的共轭加成产物 4（ R1 = Et，R2 = Ph) 定量（反/syn = 86:14）与 97% ee（反异构体）。该程序的适用性已用其他代表性的亚烷基丙二酸酯和硝基烷烃证明。由于 4 可以很容易地转化为相应的 γ-氨基酸盐酸盐 5，而不会损失非对映选择性和对映选择性，

  DOI：

  10.1021/ja047047v
• 作为产物：
  描述：

  丙二酸二异丙酯 、 环己烷基甲醛 在 titanium(IV) isopropylate 作用下， 以 异丙醇 为溶剂， 反应 51.0h， 以97%的产率得到diisopropyl 2-(cyclohexylmethylidene)malonate
  参考文献：
  名称：

  在Ti（O- i- Pr）4催化的Knöevenagel反应中使用异丙醇作为溶剂

  摘要：

  Ti（O- i- Pr）4催化醛和酮与丙二腈，氰基乙酸异丙酯和丙二酸二异丙酯的Knöevenagel反应在i -PrOH中顺利进行，得到了相应的反应产物，收率良好至高收率。通过本方法制备3-取代的香豆素。

  DOI：

  10.1016/j.tet.2005.06.008

文献信息

• Process for producing ethylene oligomers
  申请人：HANWHA TOTAL PETROCHEMICAL CO., LTD.

  公开号：US10308563B2

  公开（公告）日：2019-06-04

  The present disclosure relates to a process for producing ethylene oligomers and more particularly, to a process for oligomerizing ethylene by recycling butene, hexene, and octene in an ethylene oligomerization reaction with a catalyst system including a transition metal or transition metal precursor, a ligand with a backbone structure expressed by the following Chemical Formula 1, and a co-catalyst. [Chemical Formula 1] R1—O—Y—O—R2 or R1—OC(═O)—Y—C(═O)OR2 Herein, R1, R2 are each independently hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl, or substituted heterohydrocarbyl, and Y represents a group connecting O or C(═O)O and is hydrocarbyl, substituted hydrocarbyl, hetero hydrocarbyl, or substituted heterohydrocarbyl. According to the oligomerization method of the present disclosure, in the distribution of the produced α-olefins, C10″-C12″ α-olefins care highly distributed, the produced α-olefins have a remarkably high purity.

  本公开涉及一种生产乙烯低聚物的工艺，更具体地说，涉及一种通过在乙烯低聚反应中回收丁烯、己烯和辛烯而使乙烯低聚的工艺，该催化剂体系包括过渡金属或过渡金属前体、具有以下化学式1表示的骨架结构的配位体和助催化剂。[化学式 1] R1-O-Y-O-R2 或 R1-OC(═O)-Y-C(═O)OR2 这里，R1、R2 各自独立地为烃基、取代的烃基、杂烃基或取代的杂烃基，Y 代表连接 O 或 C(═O)O 的基团，并且是烃基、取代的烃基、杂烃基或取代的杂烃基。根据本公开的低聚方法，在生成的α-烯烃的分布中，C10″-C12″ α-烯烃的分布较多，生成的α-烯烃具有显著的高纯度。
• PROCESS FOR PRODUCING ETHYLENE OLIGOMERS
  申请人：HANWHA TOTAL PETROCHEMICAL CO., LTD.

  公开号：US20180170827A1

  公开（公告）日：2018-06-21

  The present disclosure relates to a process for producing ethylene oligomers and more particularly, to a process for oligomerizing ethylene by recycling butene, hexene, and octene in an ethylene oligomerization reaction with a catalyst system including a transition metal or transition metal precursor, a ligand with a backbone structure expressed by the following Chemical Formula 1, and a co-catalyst. [Chemical Formula 1] R 1 —O—Y—O—R 2 or R 1 —OC(═O)—Y—C(═O)OR 2 Herein, R 1 , R 2 are each independently hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl, or substituted heterohydrocarbyl, and Y represents a group connecting O or C(═O)O and is hydrocarbyl, substituted hydrocarbyl, hetero hydrocarbyl, or substituted heterohydrocarbyl. According to the oligomerization method of the present disclosure, in the distribution of the produced α-olefins, C10″-C12″ α-olefins care highly distributed, the produced α-olefins have a remarkably high purity.
• CATALYST SYSTEM FOR ETHYLENE OLIGOMERIZATION AND METHOD FOR PRODUCING ETHYLENE OLIGOMERIZATION USING THE SAME
  申请人：HANWHA TOTAL PETROCHEMICAL CO., LTD.

  公开号：US20180169642A1

  公开（公告）日：2018-06-21

  The present disclosure relates to a catalyst system for ethylene oligomerization and a method for producing ethylene oligomerization using the same and more particularly, to a catalyst system for ethylene oligomerization including a transition metal or transition metal precursor with a new structure, a ligand with a backbone structure expressed by the following Chemical Formula 1 or Chemical Formula 2, and a co-catalyst for providing an ethylene oligomer and a method for producing ethylene oligomerization using the same. [Chemical Formula 1] R 1 —OC(═O)—Y 1 —C(═O)OR 2 Herein, R 1 , R 2 are each independently hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl, or substituted heterohydrocarbyl, and Y 1 represents a group connecting CO(═O). [Chemical Formula 2] R 1 —O—Y 2 —O—R 2 Herein, R 1 , R 2 are each independently hydrocarbyl, substituted hydrocarbyl, heterohydrocarbyl, or substituted heterohydrocarbyl, and Y 2 represents a group connecting O and is a linear, branched, or cyclic alkyl group having 3 or more carbon atoms, or hetero hydrocarbyl, or substituted heterohydrocarbyl. The catalyst system of the present disclosure has an excellent catalytic activity and in the distribution of the produced α-olefins, C8″-C18″ α-olefins are highly distributed.
• Use of isopropyl alcohol as a solvent in Ti(O-i-Pr)4-catalyzed Knöevenagel reactions
  作者：Kohei Yamashita、Takanori Tanaka、Masahiko Hayashi

  DOI：10.1016/j.tet.2005.06.008

  日期：2005.8

  Knöevenagel reactions of aldehydes and ketones with malononitrile, isopropyl cyanoacetate and diisopropyl malonate catalyzed by Ti(O-i-Pr)4 proceeded smoothly in i-PrOH to give the corresponding reaction products in good to high yield. 3-Substituted coumarins were prepared by the present method.

  Ti（O- i- Pr）4催化醛和酮与丙二腈，氰基乙酸异丙酯和丙二酸二异丙酯的Knöevenagel反应在i -PrOH中顺利进行，得到了相应的反应产物，收率良好至高收率。通过本方法制备3-取代的香豆素。
• Highly Enantioselective Conjugate Addition of Nitroalkanes to Alkylidenemalonates Using Efficient Phase-Transfer Catalysis of <i>N</i>-Spiro Chiral Ammonium Bromides
  作者：Takashi Ooi、Shingo Fujioka、Keiji Maruoka

  DOI：10.1021/ja047047v

  日期：2004.9.1

  to the desired conjugate addition product 4 (R1 = Et, R2 = Ph) quantitatively (anti/syn = 86:14) with 97% ee (anti isomer). The applicability of this procedure has been demonstrated with other representative alkylidenemalonates and nitroalkanes. Since 4 can be readily transformed into the corresponding gamma-amino acid hydrochloride 5 without loss of diastereo- and enantioselectivity, the present method

  硝基烷烃与亚烷基丙二酸酯的高度对映选择性共轭加成首次通过利用 N-螺 C2-对称手性溴化季铵 1 的有效相转移催化实现。例如，简单混合硝基丙烷 (2, R1 = Et )、二异丙基苄基二烯丙二酸酯 (3, R2 = Ph)、Cs2CO3 (1 当量) 和 (S,S)-1 (1 mol%) 在甲苯中在 0 摄氏度下 2.5 小时产生所需的共轭加成产物 4（ R1 = Et，R2 = Ph) 定量（反/syn = 86:14）与 97% ee（反异构体）。该程序的适用性已用其他代表性的亚烷基丙二酸酯和硝基烷烃证明。由于 4 可以很容易地转化为相应的 γ-氨基酸盐酸盐 5，而不会损失非对映选择性和对映选择性，